Chronic Papular Eruption of the Skin
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Am Fam Physician. 1998 Jul 1;58(1):199-200.
A four-year-old child presented to the office for evaluation of a nonpruritic generalized cutaneous eruption that had been present for six months. Physical examination revealed multiple flesh-colored and tannish-brown papules, from 1 to 2 mm in diameter, on the child's torso, extremities and face (Figure 1). There was no evidence of mucocutaneous or palmoplantar involvement. The child did not have any associated systemic complaints, and a review of systems was normal. A skin biopsy was performed. Histologic examination revealed multiple foci of lymphohistiocytic infiltrates with elongation of the rete ridges around each infiltrate (Figure 2).
Which one of the following is the correct diagnosis, given the history, the physical appearance and the histopathology of these lesions?
A. Pityriasis rubra pilaris.
B. Keratosis pilaris.
C. Phrynoderma (vitamin A deficiency).
D. Generalized lichen nitidus.
E. Papular mucinosis.
The correct answer is D: Generalized lichen nitidus. Lichen nitidus is a chronic papular eruption of the skin that most commonly affects children and young adults but has been reported in the elderly.1 The eruption is usually asymptomatic and limited to the chest, abdomen, forearms, buttocks and penis.2 However, multiple clinical variants of lichen nitidus have been described, including generalized, perforating, vesicular, hemorrhagic, spinous, palmoplantar and familial.1–8 The etiology of lichen nitidus is unknown.3
Generalized lichen nitidus is a rare form of the disease with similar lesions that cover a greater body surface area. The clinical diagnosis of localized lichen nitidus is straightforward, but when the lesions disseminate, the diagnosis may become more elusive because of concern over a more aggressive dermatitis. Because of the expanded cutaneous involvement, the differential diagnosis includes pityriasis rubra pilaris, keratosis pilaris, lichen planus, phrynoderma (vitamin A deficiency) and papular mucinosis.
Diagnosis is confirmed by skin biopsy, which demonstrates well-demarcated lymphohistiocytic infiltrates with occasional giant cell formation and elongation of the rete ridges around the lateral margins of the infiltrate.3 These histologic characteristics distinguish lichen nitidus from lichen planus. Lichen planus is characterized by an intense, dermal band-like infiltrate with focal hypergranulosis in the epidermis.
The clinical course of generalized lichen nitidus is variable and often unpredictable; even so, the prognosis is good.1 Often the disease is asymptomatic and the eruption resolves spontaneously, without therapy, after several years.3 Parents of children with generalized lichen nitidus are often more concerned about the child's cosmetic appearance and often request treatment, especially if the face becomes involved. Various treatment recommendations are available for generalized lichen nitidus, but they are usually anecdotal and usually have not been studied in randomized, placebo-controlled clinical trials. Treatment methods include topical steroids, a short course of oral steroids, phototherapy and antihistamines.1–3,9,10 Obviously, some of these treatments may be toxic to children; therefore, treatment should be tailored to the individual patient. The patient described here responded to a short course of topical hydrocortisone valerate cream.
The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the policies of the Department of Defense or the Department of the Army.
1. Chen W, Schramm M, Zouboulis CC. Generalized lichen nitidus. J Am Acad Dermatol. 1997;36:630–1.
2. Sysa-Jedrzejowska A, Wozniacka A, Robak E, Waszczykowska E. Generalized lichen nitidus: a case report. Cutis. 1996;58:170–2.
3. Francoeur CJ, Frost M, Treadwell P. Generalized pinhead-sized papules in a child. Arch Dermatol. 1988;124:935–6.
4. Itami A, Ando I, Kukita A. Perforating lichen nitidus. Int J Dermatol. 1994;33:382–4.
5. Jetton RL, Eby CS, Freeman RG. Vesicular and hemorrhagic lichen nitidus. Arch Dermatol. 1972;105:430–1.
6. Madhok R, Winklemann RK. Spinous, follicular lichen nitidus associated with perifollicular granulomas. J Cutan Pathol. 1988;15:245–8.
7. Lucker GP, Koopman RJ, Steijlen PM, Van der Valk PG. Treatment of palmoplantar lichen nitidus with acitretin. Br J Dermatol. 1994;130:791–3.
8. Kato N. Familial lichen nitidus. Clin Exp Dermatol. 1995;20:336–8.
9. Ocampo J, Torne R. Generalized lichen nitidus: report of two cases treated with astemizol. Int J Dermatol. 1989;28:49–51.
10. Randle HW, Sander HM. Treatment of generalized lichen nitidus with PUVA. Int J Dermatol. 1986;25:330–1.
Contributing editor is Marc S. Berger, M.D., C.M., The Reading Hospital and Medical Center, Reading, Pennsylvania
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