Tips from Other Journals
Teratogenic Risk of SSRIs Used During Pregnancy
FREE PREVIEW Log in or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.
FREE PREVIEW Subscribe or buy this issue. AAFP members and paid subscribers get free access to all articles.
Am Fam Physician. 1998 Jul 1;58(1):243-244.
Previous studies have hinted at an increased risk of perinatal complications in pregnant women who take fluoxetine. Kulin and colleagues evaluated pregnancy outcomes in women who received selective serotonin reup-take inhibitors (SSRIs) during pregnancy.
Women who contacted the Teratology Information Service about exposure to fluvoxamine, paroxetine or sertraline during pregnancy were included in this prospective, controlled cohort study. These patients were matched with randomly selected women who received counseling but were determined to have been exposed only to nonteratogenic substances. The SSRI dosage and the length of treatment were determined, and the women were contacted about nine months after their delivery to determine the outcome of the pregnancy. Rates of major malformations (anomalies having significant medical or social consequences) were determined.
Of the 267 women included in the study, 147 used sertraline, 97 used paroxetine and 26 took fluvoxamine. The SSRI was used throughout the pregnancy by 49 women. The rates of spontaneous and elective abortion, stillbirth and major malformations were not significantly different between the SSRI and the control groups. Neonates exposed to SSRIs had a relative risk of major malformations of 1.06. Pregnancy outcomes did not differ between women who took the SSRI for only the first trimester and those who took it for the entire pregnancy.
The authors conclude that SSRIs used during pregnancy do not increase teratogenic risk when used in recommended dosages.
Kulin NA, et al. Pregnancy outcome following maternal use of the new selective serotonin reuptake inhibitors. A prospective controlled multicenter study. JAMA. February 25, 1998;279:609–10.
Copyright © 1998 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact email@example.com for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions