Am Fam Physician. 1999 Sep 1;60(3):763-764.
to the editor: We read with great interest the excellent review article on sarcoidosis by Drs. Belfer and Stevens.1 The authors reviewed the epidemiology, clinical spectrum, diagnosis, treatment and prognosis of sarcoidosis. We would like to comment on vasculitis as another possible presentation of sarcoidosis.
Vasculitis associated with sarcoidosis is rare, but it has been reported in both adults2 and children.3 In adults, reported cases have included involvement of the abdominal aorta, pulmonary granulomatous angiitis, cutaneous vasculitis and granulomatous glomerulonephritis.2,4,5 A review of the literature reveals a wide spectrum of vasculitis in childhood sarcoidosis, including leukocytoclastic vasculitis, systemic vasculitis of small- to medium-sized vessels and large-vessel vasculitis.6
We suggest that all patients with sarcoidosis be followed carefully for the development of vessel wall disease.
1. Belfer MH, Stevens RW. Sarcoidosis: a primary care review. Am Fam Physician. 1998;58:2041–50.
2. Thompson JR. Vascular changes in sarcoidosis. Dis Chest. 1966;50:357–61.
3. Gross KR, Malleson PN, Culham G, Lirenman DS, McCormick AQ, Petty RE. Vasculopathy with renal artery stenosis in a child with sarcoidosis. J Pediatr. 1986;108(5 pt 1):724–6.
4. Maeda S, Murao S, Sugiyama T, Utaka I, Okamoto R. Generalized sarcoidosis with “sarcoid aortitis. Acta Pathol Jpn. 1983;33:183–8.
5. Muther RS, McCarron DA, Bennett WM. Renal manifestations of sarcoidosis. Arch Intern Med. 1981;141:643–5.
6. Shetty AK, Gedalia A. Sarcoidosis: a pediatric perspective. Clin Pediatr. 1998;37:707–17.
Send letters to Kenneth W. Lin, MD, MPH, Associate Deputy Editor for AFP Online, e-mail: firstname.lastname@example.org, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680.
Please include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.
Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the American Academy of Family Physicians permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.
Copyright © 1999 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact email@example.com for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions