Nov 15, 1999 Table of Contents

Please note: This information was current at the time of publication. But medical information is always changing, and some information given here may be out of date. For regularly updated information on a variety of health topics, please visit familydoctor.org, the AAFP patient education Web site.

Information from Your Family Doctor

Flexible Insulin Regimens for People with Type 1 Diabetes

Am Fam Physician. 1999 Nov 15;60(8):2355-2356.

See related article on type 1 diabetes mellitus.

What is insulin?

Insulin is a hormone that controls the level of sugar (also called glucose) in your body. When you have type 1 diabetes, your body doesn't make enough insulin. This causes sugar to build up in your blood. Over time, high blood sugar levels can cause serious health problems, such as blindness, kidney problems and damage to the nerves that go to your legs and feet.

It's very important for you to keep your blood sugar level as close to normal as possible. If you can do this, you can avoid or delay many of the serious health problems caused by diabetes.

How do I use insulin?

Because your body doesn't make enough insulin, you must give yourself insulin with injections, an insulin pen or an insulin pump. There are different kinds of insulin (see box at right). They all start working and keep working at different speeds. Your doctor will talk with you about what insulin to use. Your doctor might want you to use more than one kind of insulin every day. Some insulins can be mixed together.

Often, people with diabetes are helped by a team of health care professionals. Nurses with special training in diabetes treatment can explain how to take insulin and show you how to give yourself the injections. Dieticians, who have special training in nutrition, can help you find a healthy diet. This health care team can give you help with insulin doses if you have trouble keeping your blood sugar level close to normal.

Types of insulin

Rapid-acting, such as insulin lispro; this insulin starts to work very quickly (within 15 minutes) and lasts for 3 to 4 hours. A similar kind of insulin is insulin aspart; it will be available in 2000.

Short-acting, such as Regular (R) insulin; this insulin starts working within 30 minutes and lasts about 6 to 8 hours. It reaches its peak in 2 to 4 hours.

Intermediate-acting, such as NPH (N) or Lente (L) insulin; this insulin starts working in 1 to 3 hours and lasts 16 to 24 hours.

Long-acting, such as Ultralente (U) insulin; this insulin doesn't start to work for 4 to 6 hours but lasts 20 to 24 hours. It reaches its peak in 8 to 10 hours. A new insulin, called insulin glargine, lasts for 24 hours but has no peak. It will be available in 2000.

What is a flexible insulin regimen?

A flexible insulin regimen is one that lets you adjust the timing and amount of insulin to meet your needs. With a conventional regimen, you take insulin at set times and have to follow a strict schedule. A flexible regimen allows for changes in your schedule and lets you adjust your insulin as needed. For example, you might increase the dose of insulin if you eat a meal with a lot of carbohydrates. Or you might lower your insulin dose if you're going to exercise. A flexible regimen also may help you keep tighter control over your blood sugar level.

A flexible insulin regimen has benefits, but it means you'll have to make some extra effort. You must check your blood sugar level regularly and keep track of what you eat (this means counting the carbohydrates you eat). You must also learn how your body reacts to insulin and how to adjust your dose. Too much insulin can give you hypoglycemia (blood sugar level is too low). Too little insulin can give you hyperglycemia (blood sugar level is too high). Both of these conditions can be dangerous to your health.

When should I take insulin?

Your doctor and the health care team will talk with you about when to take insulin. Remember that some insulins start working faster, while others keep working longer. It's important to pay attention to the time between taking insulin and eating a meal. For example, regular insulin has to be taken 20 to 30 minutes before eating. Insulin lispro should be taken no more than 15 minutes before eating a meal, because it works faster.

Why should I count carbohydrates?

Carbohydrates can change the amount of insulin you need to take. Your doctor or someone in your diabetes care team can teach you how to count grams of carbohydrates and how to adjust the amount of insulin you take, depending on what you eat.


This handout is provided to you by your family doctor and the American Academy of Family Physicians. Other health-related information is available from the AAFP online at http://familydoctor.org.

This information provides a general overview and may not apply to everyone. Talk to your family doctor to find out if this information applies to you and to get more information on this subject.

Copyright © 1999 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact afpserv@aafp.org for copyright questions and/or permission requests.

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