Correction

Am Fam Physician. 2000 May 15;61(10):2972.

An item in “Tips from Other Journals,” entitled “Overview of Methods for Treating Allergic Rhinitis” (January 1, 2000, page 207), contained dosage errors in the accompanying table on second-generation antihistamines. The dosage approved by the U.S. Food and Drug Administration for cetirizine is 5 to 10 mg once daily; the approved dosage for loratadine is 10 mg once daily and the approved dosage for loratadine with pseudoephedrine is 10 mg/240 mg once daily. The half-life of claritin was misstated; it is 28 hours. The corrected table is reprinted below.

TABLE 1

Second-Generation Antihistamines

Generic Brand Onset of action Half-life Usual dosage Cost* Comments

Cetirizine

Zyrtec

15 to 30 minutes

7 to 9 hours

5 to 10 mg daily

$55.80

Also available in syrup (5 mg per 5 mL); may cause drowsiness

Fexofenadine

Allegra

1 hour

14 to 18 hours

60 mg twice daily

59.65

Fexofenadine/Pseudoephedrine

Allegra-D

60 mg/120 mg twice daily

66.71

Active metabolite of terfenadine; devoid of cardiotoxic risk

Loratadine

Claritin

1 to 3 hours

28 hours

10 mg daily

65.66

Also available in syrup (5 mg per 5 mL) and rapidly disintegrating tablets

Loratadine/Pseudoephedrine

Claritin-D 12

5 mg/120 mg twice daily

74.00

Claritin-D 24

10 mg/240 mg daily

73.49

Azelastine

Astelin

Within 1 hour

22 to 25 hours

2 sprays per nostril twice daily

44.76

May cause drowsiness


*—Estimated cost to the pharmacist based on average wholesale prices in Red book. Montvale, N.J.: Medical Economics Data, 1999. Cost to the patient will be higher, depending on prescription filling fee.

Reprinted with permission from Lee NP, Arriola ER. How to treat allergic rhinitis. West J Med 1999;171:31–4.

TABLE 1   Second-Generation Antihistamines

View Table

TABLE 1

Second-Generation Antihistamines

Generic Brand Onset of action Half-life Usual dosage Cost* Comments

Cetirizine

Zyrtec

15 to 30 minutes

7 to 9 hours

5 to 10 mg daily

$55.80

Also available in syrup (5 mg per 5 mL); may cause drowsiness

Fexofenadine

Allegra

1 hour

14 to 18 hours

60 mg twice daily

59.65

Fexofenadine/Pseudoephedrine

Allegra-D

60 mg/120 mg twice daily

66.71

Active metabolite of terfenadine; devoid of cardiotoxic risk

Loratadine

Claritin

1 to 3 hours

28 hours

10 mg daily

65.66

Also available in syrup (5 mg per 5 mL) and rapidly disintegrating tablets

Loratadine/Pseudoephedrine

Claritin-D 12

5 mg/120 mg twice daily

74.00

Claritin-D 24

10 mg/240 mg daily

73.49

Azelastine

Astelin

Within 1 hour

22 to 25 hours

2 sprays per nostril twice daily

44.76

May cause drowsiness


*—Estimated cost to the pharmacist based on average wholesale prices in Red book. Montvale, N.J.: Medical Economics Data, 1999. Cost to the patient will be higher, depending on prescription filling fee.

Reprinted with permission from Lee NP, Arriola ER. How to treat allergic rhinitis. West J Med 1999;171:31–4.


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