Successful Management of the Obese Patient



FREE PREVIEW Log in or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.


FREE PREVIEW Subscribe or buy this issue. AAFP members and paid subscribers get free access to all articles.

Am Fam Physician. 2000 Jun 15;61(12):3615-3622.

Obesity is a chronic disease that affects a substantial number of Americans. Obesity significantly increases a person's risk of cardiovascular diseases and morbidity. Modification of lifestyle behaviors that contribute to obesity (e.g., inappropriate diet and inactivity) is the cornerstone of treatment. Behavior modification involves using such techniques as self-monitoring, stimulus control, cognitive restructuring, stress management and social support to systematically alter obesity-related behaviors. In addition, adjunctive pharmacotherapy can play an important role in the routine medical management of obesity.

Obesity is epidemic in the United States and other industrialized nations.1 Currently, obesity is defined as a body mass index (BMI = weight in kilograms divided by height in meters squared) of 30 kg per m2 or more.1 There are three classes of severity: Class I (BMI of 30.0 to 34.9 kg per m2), Class II (BMI of 35.0 to 39.9 kg per m2) and Class III (BMI of equal to or greater than 40.0 kg per m2).1 The age-adjusted prevalence rates of Class I, II and III obesity in American adults are estimated to be 14.4, 5.2 and 2.9 percent, respectively.1 These estimates represent a substantial increase in the prevalence of all three obesity classes over the past decade.

Obese persons have a greater mortality risk, compared with nonobese persons.1,2 In particular, obesity increases the risk of cardiovascular disease-related mortality one- to twofold.1,3 Results of one study found that a BMI greater than 35 was associated with a sevenfold increase in mortality risk in coronary patients.4 Obesity is also associated with increased risk of multiple comorbid medical conditions, including hypertension, dyslipidemia, coronary heart disease, type 2 diabetes mellitus (formerly called non–insulin-dependent diabetes mellitus), gallbladder disease, sleep apnea, osteoarthritis and various forms of cancer.1,4

One study found that obese persons (BMI of 30 or greater) are substantially more likely to have a comorbid medical condition, compared with persons who have BMIs in the healthy range (19.0 to 24.9 kg per m2).5 In this study, obese subjects were 1.7 times more likely to have heart disease, twice as likely to have hypertension and three times as likely to have diabetes, compared with persons in the healthy BMI range. The American Heart Association (AHA), in its call to action on obesity and heart disease, reclassified obesity as a major, modifiable risk factor for coronary heart disease.6

Successful Management of Obesity

Successful management of the obese patient involves multiple treatment strategies, most focusing on modification of the patient's lifestyle (e.g., diet and physical activity habits). Behavior modification, although not an intervention itself, is a systematic method for modifying eating, exercise or other behaviors that may contribute to or maintain obesity.7 Behavior modification techniques include self-monitoring, stimulus control, cognitive restructuring, stress management and social support.

SELF-MONITORING

Self-monitoring is the systematic observation and recording of target behaviors. Self-monitoring tools include the following: food diaries to record total caloric intake, total fat grams consumed, food groups used, and conditions or situations when overeating is common; physical activity logs to record frequency, duration and intensity of exercise; and weight scales or body composition measures to record changes in weight, body fat or lean body mass. Although patients are not always accurate in reporting their diet and exercise behaviors,8 the primary purpose of self-monitoring is for patients to become more aware of their behaviors and the factors that influence their behaviors in ways that are beneficial or detrimental to their weight management efforts. Research has consistently demonstrated that self-monitoring is associated with improved treatment outcomes, and patients report that it is one of the most helpful tools in obesity management.911

Current guidelines from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) suggest that persons who desire to lose weight should reduce their caloric intake by 500 to 1,000 kcal per day, which will produce a weight loss of 0.45 to 0.90 kg (1 to 2 lb) per week.1 According to the NHLBI guidelines,1 women may choose a diet of 1,000 to 1,200 kcal per day and men may choose a diet of 1,200 to 1,500 kcal per day.

STIMULUS CONTROL

Stimulus control involves identifying and modifying the environmental cues that are associated with a patient's overeating and inactivity. By changing their individual environments, patients may be more successful in sustaining their weight management behaviors.12 Controlling cues associated with overeating or a sedentary lifestyle can be helpful for long-term maintenance because exposure to these cues may precipitate relapse.12 Suggestions for ways patients can implement this strategy include: eating only at the kitchen table without watching television; keeping no snack foods in the house; and laying out exercise clothes the night before as a reminder to walk or jog in the morning. Patients and their physicians should work together to develop practical, individualized stimulus control strategies that will fit the patient's lifestyle.

COGNITIVE RESTRUCTURING

Cognitive restructuring increases patient awareness of their perceptions of themselves and their weight. In addition, patients learn to actively change internal dialogue that undermines their weight management efforts. Cognitive restructuring is important because many obese patients have poor self-esteem and a distorted body image. Many are unrealistic about how much weight they can lose and the benefits that weight loss can have on their life. One obesity treatment study found that patients had weight loss expectations that were substantially greater than what was realistically attainable.13 Although most patients in this study lost about 10 percent of their initial weight during treatment,1 this “modest” amount of weight loss was disappointing to the patients.13

Stress Management

Because stress is a primary predictor of relapse and overeating,11 teaching patients various methods for reducing stress and tension is crucial. Tension reduction techniques (e.g., diaphragmatic breathing, progressive muscle relaxation and meditation) are designed to reduce tension and associated sympathetic nervous system arousal, thereby providing a distraction from stressful events. These strategies are highly effective for numerous health-related problems, including obesity.14

SOCIAL SUPPORT

Persons with higher levels of social support tend to have more success achieving and maintaining weight loss.11 Social support can come from inclusion of the family in the obesity treatment program, participation in community-based programs or involvement in outside social activities (e.g., university or community education courses, health clubs and church-related activities). These groups or programs do not need to be oriented toward weight management. Peer support can be particularly useful in helping patients become more self-accepting, develop new norms for interpersonal relationships and manage stressful work- or family-related situations.11,12

EFFECTIVENESS OF BEHAVIORAL STRATEGIES

Obesity interventions that incorporate these behavioral strategies are generally effective in producing gradual and moderate weight loss. Numerous studies over the past two decades show that the average weight loss is 0.45 kg (1 lb) per week and more than 8 kg (17.6 lb) over the total treatment period. Attrition rates are generally low (less than 18 percent), and the use of multiple behavioral strategies appears to be associated with greater weight loss.1,15 Behavior modification interventions last about 18 weeks and usually include multiple treatment strategies. Patients are able to maintain, on average, about two thirds of their initial weight loss nine to 10 months after treatment termination.1,15 Studies consistently show that behavior modification strategies, extended treatment and physical activity are excellent predictors of weight loss during treatment.11,16

The Importance of Physical Activity in Weight Maintenance

Regular physical activity is associated with reductions in many medical comorbidities associated with obesity.1,17 Physical activity is an important predictor of weight maintenance,1,17 and the results of at least one study suggest that being physically active, even if the patient is obese, can substantially reduce one's risk for all-cause mortality.18 This study found that moderately and highly fit men, irrespective of their BMI, experienced significantly lower age-adjusted risk for all-cause mortality, compared with sedentary or low-fit men.18 The finding suggests the possibility of "healthy" obesity (persons who are obese but physically fit) and highlights the importance of increasing physical activity regardless of weight changes.

The American College of Sports Medicine recommends specific guidelines for exercise-induced weight loss.19 The exercise program should promote an expenditure of 300 to 500 kcal per session and 1,000 to 2,000 kcal per week for adults. However, this goal may not be realistic for the severely obese person. Thus, according to NHLBI guidelines,1 obese patients should start with moderate levels of physical activity (e.g., brisk walking) for 30 to 45 minutes, three to five days per week (an expenditure of about 150 to 225 kcal per session), working up to exercise sessions on most, and preferably all, days of the week.

The Role of Pharmacotherapy

Although behavior modification strategies are helpful for most obese patients, they do not guarantee long-term weight-loss maintenance. Without recurrent contact, most or all of the weight patients lose can be regained within three to five years.15 This limitation contributed to the active development of pharmacologic approaches to obesity. Current guidelines consider pharmacotherapy to be an adjunct to lifestyle modification programs and are targeted toward at-risk patients (patients with a BMI of 30 or greater, or a BMI of 27 or greater combined with medical comorbidities).1,20 Several early studies21,22 evaluated the effectiveness of drug treatment alone (using fenfluramine administered during brief physician visits), behavior therapy alone and drug treatment combined with behavior therapy. Behavior therapy alone and drug treatment combined with behavior therapy produced substantially greater weight loss at the end of the treatment period when compared with the wait-list control group or the patients receiving the drug alone.21,22

Studies of obesity medications, usually in conjunction with dietary programs, demonstrate modest benefits compared with studies of behavior modification programs and placebo.1  The effects of pharmacotherapy tend to maximize within six months, and weight loss is generally maintained for the duration of treatment. Currently available obesity medications are listed in Table 1.

TABLE 1.

Medications Labeled by the FDA for the Treatment of Obesity

Agent DEA schedule Action

Diethylpropion (Tenuate)

IV

Noradrenergic

Mazindol (Sanorex)

IV

Noradrenergic

[corrected] Orlistat* (Xenical)

Lipase inhibitor

Phendimetrazine (Plegine)

III

Noradrenergic

Phentermine (Fastin)

IV

Noradrenergic

Phentermine resin (Ionamin)

IV

Noradrenergic

Phenylpropanolamine (Dexatrim)

OTC

Noradrenergic

Sibutramine* (Meridia)

IV

SNRI


FDA = U.S. Food and Drug Administration; DEA = Drug Enforcement Administration; OTC = over-the-counter; SNRI = serotonergic noradrenergic reuptake inhibitor.

*—Orlistat and sibutramine are the only drugs labeled by the FDA for long-term treatment of obesity.

TABLE 1.   Medications Labeled by the FDA for the Treatment of Obesity

View Table

TABLE 1.

Medications Labeled by the FDA for the Treatment of Obesity

Agent DEA schedule Action

Diethylpropion (Tenuate)

IV

Noradrenergic

Mazindol (Sanorex)

IV

Noradrenergic

[corrected] Orlistat* (Xenical)

Lipase inhibitor

Phendimetrazine (Plegine)

III

Noradrenergic

Phentermine (Fastin)

IV

Noradrenergic

Phentermine resin (Ionamin)

IV

Noradrenergic

Phenylpropanolamine (Dexatrim)

OTC

Noradrenergic

Sibutramine* (Meridia)

IV

SNRI


FDA = U.S. Food and Drug Administration; DEA = Drug Enforcement Administration; OTC = over-the-counter; SNRI = serotonergic noradrenergic reuptake inhibitor.

*—Orlistat and sibutramine are the only drugs labeled by the FDA for long-term treatment of obesity.

Noradrenergic Drugs. One class of weight-loss medications is the noradrenergic drugs that affect weight loss by suppressing one's appetite. Some noradrenergic agents include: phentermine resin (Ionamin), mazindol (Sanorex), phenylpropanolamine (Dexatrim), phendimetrazine (Plegine) and diethylpropion (Tenuate). When combined with dietary programs, these drugs produced modest short-term net weight losses compared with dietary changes and placebo. The U.S. Food and Drug Administration (FDA) has not labeled any of these drugs for long-term treatment of obesity.

Orlistat. Orlistat (Xenical) is a lipase inhibitor23 that has been approved by the FDA for long-term use. After 12 weeks of treatment with orlistat (360 mg per day), patients in a clinical study showed weight losses of up to 5 kg (11 lb), compared with 2-to 3-kg losses (4.4 to 6.6 lb) among patients in the placebo group.23,24 Weight losses appear to be dosage-dependent, with lower dosages producing smaller weight losses, and some patients report mild and transient gastrointestinal side effects. The results of a 52-week randomized, double-blind, clinical trial demonstrated sustained weight loss in the treatment group (120 mg three times daily), averaging a weight loss of 3 kg (6.6 lb) more than the placebo group.25

A more recent study26 found that patients treated with orlistat over a two-year period experienced significant improvements in several health parameters. For example, during the first year, patients receiving orlistat lost more weight than patients receiving a placebo. Patients treated with orlistat (120 mg, three times per day) during years 1 and 2 regained less weight during year 2 than patients treated with orlistat (60 mg three times per day) or placebo. Treatment with orlistat (120 mg three times per day) was also associated with improvements in fasting low-density lipoprotein (LDL) cholesterol levels and insulin levels.26

In a one-year randomized, double-blind study of obese patients with type 2 diabetes, patients receiving orlistat lost more weight than patients receiving a placebo.27 In addition, patients treated with orlistat plus a modification of their diet showed reductions in dosage of sulfonylurea medications and significant improvements in hemoglobin A1c (HbA1c) fasting plasma glucose levels, and lipid parameters (total cholesterol levels, LDL cholesterol levels, triglyceride [TG] levels, apolipoprotein B levels, and the LDL-to-high-density–lipoprotein [HDL] ratio) when compared with placebo plus diet modifications.27

Sibutramine. Sibutramine (Meridia), which has been approved by the FDA for long-term treatment of obesity, is a specific reuptake inhibitor of norepinephrine and serotonin, thus having satiating and potential thermogenic effects.28,29 Preclinical studies in animal models showed that sibutramine and its metabolites reduced food intake and that animals eating a high-fat diet were more sensitive to sibutramine.28 Several clinical studies of 12 to 52 weeks' duration showed weight losses of 4.7 to 7.6 kg (10.3 to 16.7 lb) in patients receiving sibutramine.30,31 Weight losses were dosage-dependent and tended to plateau by the 24th week. Efficacy of sibutramine at one year has also been established. Patients taking 5-, 10-, and 15-mg daily dosages experienced dosage-related weight loss for up to 12 weeks, and all dosages were well-tolerated.31

A 52-week trial30 of sibutramine found that patients receiving the 10 mg per day dosage, the 15 mg per day dosage, and a placebo lost 4.8 kg (10.6 lb), 6.1 kg (13.4 lb), and 1.8 kg (4.0 lb), respectively. The percentage of patients who lost at least 5 percent of their initial body weight over a 21-month period was 56 percent in the patients taking 10 mg per day, 65 percent in the patients taking 15 mg per day, and only 29 percent in the subjects receiving placebo. Thirty percent of the subjects taking 10 mg per day and 39 percent of subjects in the group receiving 15 mg per day reached the 10 percent loss of initial body weight criteria while only 8 percent of subjects in the placebo group reached that level of weight loss.30 Treatment with sibutramine also can improve many obesity-related comorbidities.28,29

A one-year study of patients using 10 or 15 mg per day of sibutramine found significant reductions in waist-to-hip ratio compared with patients receiving placebo.30 Sibutramine-induced weight losses have also been found to produce favorable reductions in plasma TG, total cholesterol, LDL and HbA1c levels.30 In a 12-week study,32 91 patients with type 2 diabetes were randomized to receive 15 mg of sibutramine or placebo. Patients who received sibutramine showed moderate but significant weight loss as well as improvements in HbA1c levels, compared with patients in the placebo group.

All drug therapies can have adverse effects that may include depression, neurotoxicity, valvular heart disease, primary pulmonary hypertension, and the potential for abuse of or the development of tolerance to the drug being taken.33,34 Other side effects can include diarrhea, polyuria, dry mouth, sleep disturbance, nervousness, sexual dysfunction and increased blood pressure, but these effects are generally mild to moderate and tend to ameliorate with continued treatment.1 Reviews of pharmacotherapy for weight management are available.3336

Systemic side effects of orlistat are minimal because it acts on gastrointestinal lipases and is minimally absorbed.26 Adverse events tend to be similar in orlistat- and placebo-treated groups26,27 with the exception of gastrointestinal events. Gastrointestinal symptoms typically include flatus with discharge, oily spotting, fecal urgency, fatty/oily stool, oily evacuation, fecal incontinence and increased defecation.26 These symptoms are predictable, tend to diminish over time, and tend to be more pronounced in patients who have difficulty maintaining a moderate dietary fat intake. Absorption of fat-soluble vitamins (A, D and E) and carotenoids may be affected, so the use of orlistat should be supplemented with a multivitamin.

Side effects of sibutramine include mean increases of 1 to 3 mm Hg in systolic blood pressure (SBP) and diastolic blood pressure (DBP) and an increase in pulse rate. Increases in blood pressure may be partially mitigated by sibutramine-related weight losses.30 In controlled safety trials, 0.4 percent of patients treated with sibutramine and 0.4 percent of patients who received a placebo discontinued use because of hypertension (SBP greater than 160 mm Hg; DBP greater than 95 mm Hg), while 0.4 percent of patients treated with sibutramine and 0.1 percent of patients who received a placebo discontinued use because of tachycardia (pulse rate greater than 100 beats per minute). In placebo-controlled trials, the most common side effects were dry mouth, anorexia, insomnia and constipation. No cases of primary pulmonary hypertension or valvular heart disease have been reported to be associated with sibutramine.30,31

Assessing Treatment Outcome

Although the primary goal of obesity treatment programs is weight loss, there are now broader definitions of what constitutes successful treatment. More emphasis is being placed on outcomes such as improvements in metabolic profiles and comorbid medical conditions (e.g., hypercholesterolemia, diabetes); physical activity; self-esteem; body image; self-efficacy; mood and psychologic status; quality of life; and activities of daily living or functional status.13 Methods for measuring these outcomes must be incorporated in a comprehensive obesity management program.

Summary

Obesity is a chronic disease with no known cure. It requires long-term management similar to that of diabetes and hypertension.5 The use of long-term management strategies for chronic diseases is not perceived as treatment failure. Nor is treatment considered ineffective when a patient has difficulty adhering to the interventions. Rather, we acknowledge that many health care problems require long-term management and a focus on improving adherence to treatment. Obesity is best thought of and treated as a chronic disease requiring continuous care.

Given this chronic disease model of obesity, treatment should no longer require large weight losses. Modest, sustained weight losses (5 to 10 percent of initial body weight) have been shown to positively modify many comorbid disease risk factors.1 Patients and physicians should focus on making lifestyle changes in small steps that lead to moderate and lasting weight losses. Because of the inherent difficulties in treating obesity, physicians should also attempt to develop continuous care programs emphasizing lifestyle modifications, such as enduring changes in dietary and activity habits. Patients using behavior modification strategies to make these changes are more likely to succeed in long-term weight maintenance.11,16  Table 2 provides a summary of basic obesity treatment recommendations.

TABLE 2.

Recommendations for the Management of Obesity

Behavioral strategies

Use multiple strategies (e.g., combine cognitive restructuring, self-monitoring, social support, stimulus control and stress management).

Dietary intake

Reduce caloric intake by 500 to 1,000 kcal per day to produce a weight loss of 1 to 2 lb per week.

Physical activity

Obese patients should start with moderate levels of physical activity (e.g., brisk walking) for 30 to 45 minutes, three to five days per week. All patients should accumulate at least 30 minutes or more of moderate intensity physical activity on most, and preferably all, days of the week.

Adjunctive pharmacotherapy

Consider drug treatment for patients with a BMI of 30 or greater, or a BMI of 27 or greater combined with medical comorbidities.


BMI = body mass index.

TABLE 2.   Recommendations for the Management of Obesity

View Table

TABLE 2.

Recommendations for the Management of Obesity

Behavioral strategies

Use multiple strategies (e.g., combine cognitive restructuring, self-monitoring, social support, stimulus control and stress management).

Dietary intake

Reduce caloric intake by 500 to 1,000 kcal per day to produce a weight loss of 1 to 2 lb per week.

Physical activity

Obese patients should start with moderate levels of physical activity (e.g., brisk walking) for 30 to 45 minutes, three to five days per week. All patients should accumulate at least 30 minutes or more of moderate intensity physical activity on most, and preferably all, days of the week.

Adjunctive pharmacotherapy

Consider drug treatment for patients with a BMI of 30 or greater, or a BMI of 27 or greater combined with medical comorbidities.


BMI = body mass index.

Finally, it is crucial that physicians become more involved in the prevention of obesity. Currently, 13.7 and 11.5 percent of children and adolescents, respectively, are obese.1 Because childhood obesity is associated with adult obesity, physicians should intervene early with overweight children and their parents. The AHA, in its call to action on obesity,12 states that the development of obesity prevention in children is key to decreasing the current obesity epidemic. This critical health issue needs to be seriously addressed, or the long-term social and economic toll on the nation will be incalculable.

The Authors

WALKER S. CARLOS POSTON II, M.P.H., PH.D., is an assistant professor at the University of Missouri–Kansas City, and co-director of Behavioral Cardiology Research at the Mid America Heart Institute, Kansas City, Mo. Dr. Poston received a doctorate in philosophy from the University of California, Santa Barbara, and he recently received a masters in public health from the University of Texas, Houston Health Sciences Center. He completed a clinical psychology residency at the U.S. Air Force Medical Center, Wright-Patterson Air Force Base, Dayton, Ohio, and a clinical fellowship in health psychology and behavioral medicine at Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Tex.

JOHN P. FOREYT, PH.D., is a professor of medicine and psychiatry at Baylor College of Medicine, Houston, Tex. He is also director of the Behavioral Medicine Research Center, Baylor College of Medicine, Houston, and a medical scientist at the Methodist Hospital, Houston. Dr. Foreyt received a doctorate in philosophy at Florida State University, Tallahassee, Fla.

Address correspondence to Walker S. Poston II, M.P.H., Ph.D., University of Missouri–Kansas City, 5319 Holmes, Kansas City, MO 64110 (e-mail: postonwa@umkc.edu). Reprints are not available from the authors.

REFERENCES

1. National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Washington, D.C.: U.S. Government Press, 1998. Guidelines available at http://www.nhlbi.nih.gov/guidelines/obesity/ob_gdlns.htm.

2. Solomon CG, Manson JE. Obesity and mortality: a review of the epidemiologic data. Am J Clin Nutr. 1997;66:1044S–50S.

3. Singh PN, Lindstead KD. Body mass and 26-year risk of mortality from specific diseases among women who never smoked. Epidemiology. 1998;9:246–54.

4. Ellis SG, Elliott J, Horrigan M, Raymond RE, Howell G. Low-normal or excessive body mass index: newly identified and powerful risk factors for death and other complications with percutaneous coronary intervention. Am J Cardiol. 1996;78:642–6.

5. Quesenberry CP, Caan B, Jacobson A. Obesity, health services use, and health care costs among members of a health maintenance organization. Arch Intern Med. 1998;158:466–72.

6. Eckel RH, Krauss RM. American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee [news]. Circulation. 1998;97:2099–100.

7. Stunkard AJ. Current views on obesity. Am J Med. 1996;100:230–6.

8. Lichtman SW, Pisarska K, Berman ER, Pestone M, Dowling H, Offenbacher E, et al. Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. N Engl J Med. 1992;327:1893–8.

9. Baker RC, Kirschenbaum DS. Self-monitoring may be necessary for successful weight control. Behav Ther. 1993;24:377–94.

10. Boutelle KN, Kirschenbaum DS. Further support for consistent self-monitoring as a vital component of successful weight control. Obes Res. 1998;6:219–24.

11. Kayman S, Bruvold W, Stern JS. Maintenance and relapse after weight loss in women: behavioral aspects. Am J Clin Nutr. 1990;52:800–7.

12. Foreyt JP, Goodrick GK. Evidence for success of behavior modification in weight loss and control. Ann Intern Med. 1993;119:698–701.

13. Foster GD, Wadden TA, Vogt RA, Brewer G. What is a reasonable weight loss? Patients' expectations and evaluations of obesity treatment outcomes. J Consult Clin Psychol. 1997;65:79–85.

14. Everly GS. A clinical guide to the treatment of the human stress response. New York: Plenum Press, 1989.

15. Wing RR. Behavioral approaches to the treatment of obesity. In: Bray GA, Bouchard C, James WP, eds. Handbook of obesity. New York: Marcel Dekker 1998:855–73.

16. McGuire MT, Wing RR, Klem ML, Seagle HM, Hill JO. Long-term maintenance of weight loss: do people who lose weight through various weight loss methods use different behaviors to maintain their weight? Int J Obes Relat Metab Disord. 1998;22:572–7.

17. US Dept of Health and Human Services, Office of the Surgeon General Physical activity and health: a report of the surgeon general Atlanta, Ga: US Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996.

18. Barlow CE, Kohl HW 3d, Gibbons LW, Blair SN. Physical fitness, mortality, and obesity. Int J Obes Relat Metab Disord. 1995;19:S41–4.

19. Mahler DA, American College of Sports Medicine (ACSM). ACSM’s guidelines for exercise testing and prescription, 5th ed. Baltimore, MD: Williams and Wilkins, 1995.

20. The North American Association for the Study of Obesity (NAASO). Guidelines for the approval and use of drugs to treat obesity: a position paper of the North American Association for the Study of Obesity. Obes Res. 1995;3:473–8.

21. Stunkard AJ, Craighead LW, O'Brien R. Controlled trial of behaviour therapy, pharmacotherapy, and their combination in the treatment of obesity. Lancet. 1980;2:1045–7.

22. Craighead LW, Stunkard AJ, O'Brien RM. Behavior therapy and pharmacotherapy for obesity. Arch Gen Psychiatry. 1981;38:763–8.

23. Guerciolini R. Mode of action of orlistat. Int J Obes Relat Metab Disord. 1997;21(suppl 3):S12–23.

24. Drent ML, Larsson I, William-Olsson T, Quaade F, Czubayko F, von Bergmann K, et al. Orlistat (RO 18–0647), a lipase inhibitor, in the treatment of human obesity: A multiple dose study. Int J Obes Relat Metab Disord. 1995;19:221–6.

25. James WP, Avenell A, Broom J, Whitehead J. A one-year trial to assess the value of orlistat in the management of obesity. Int J Obes Relat Metab Disord. 1997;21(suppl 3):S24–30.

26. Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, et al. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA. 1999;281:235–42.

27. Hollander PA, Elbein SC, Hirsch IB, Kelley D, McGill J, Taylor T, et al. Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study. Diabetes Care. 1998;21:1288–94.

28. Heal DJ, Aspley S, Prow MR, Jackson HC, Martin KF, Cheetham SC. Sibutramine: A novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Int J Obes Relat Metab Disord. 1998;22(suppl 1):S18–28.

29. Van Gaal LF, Wauters MA, De Leeuw IH. Anti-obesity drugs: what does sibutramine offer? An analysis of its potential contribution to obesity treatment. Exp Clin Endocrinol Diabetes. 1998;106(suppl 2):35–40.

30. Lean ME. Sibutramine—a review of clinical efficacy. Int J Obes Relat Metab Disord. 1997;21(suppl 1):S30–6.

31. Seagle HM, Bessesen DH, Hill JO. Effects of sibutramine on resting metabolic rate and weight loss in overweight women. Obes Res. 1998;6:115–21.

32. The 6th European Congress on Obesity. Copenhagen, Denmark, May 31–June 3, 1995.Abstracts Int J Obes Relat Metab Disord. 1995;19(suppl 2):1–167.

33. National Task Force on the Prevention and Treatment of Obesity. Long-term pharmacotherapy in the management of obesity. JAMA. 1996;276:1907–15.

34. Scheen AJ, Lefebvre PJ. Pharmacological treatment of obesity: present status. Int J Obes Relat Metab Disord. 1999;23(suppl 1):47–53.

35. Poston WS 2d, Foreyt JP, Borrell L, Haddock CK. Challenges in obesity management. S Med J. 1998;91:710–20.

36. Bray GA. Pharmacological treatment of obesity. In: Bray GA, Bouchard C, James WP, eds. Handbook of obesity. New York: Marcel Dekker, 1998:953–75.

This article is one in a series developed in collaboration with the American Heart Association. Guest editor of the series is Rodman D. Starke, M.D., Senior Vice President of Science and Medicine, American Heart Association, Dallas.


Copyright © 2000 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact afpserv@aafp.org for copyright questions and/or permission requests.

Want to use this article elsewhere? Get Permissions


Article Tools

  • Print page
  • Share this page
  • AFP CME Quiz

Information From Industry

More in AFP

More in Pubmed

Navigate this Article