Photo Quiz

Evaluation of an Umbilical Lesion



FREE PREVIEW Login or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.

Am Fam Physician. 2000 Aug 1;62(3):623-624.

An 84-year-old woman presented for evaluation of various benign skin lesions and was incidentally noted to have an 8-mm violaceous nodule in the umbilicus (Figure 1). The patient's medical history was significant only for prior cholecystectomy, total hysterectomy and oophorectomy.

FIGURE 1.

View Large


FIGURE 1.


FIGURE 1.

Question

Given the results of the physical examination and the history, which one of the following is the most appropriate management of the lesion pictured?

A. Cryotherapy with liquid nitrogen.

B. Testing for human immunodeficiency virus.

C. Reassurance that this represents a benign lesion.

D. Fine-needle aspiration or tissue biopsy.

E. Incision and drainage of lesion.

Discussion

The answer is D: fine-needle aspiration or tissue biopsy. Sister Joseph's nodule is a lymphatic metastasis to the umbilical region. The differential diagnosis of an umbilical nodule includes, but is not limited to, granuloma (pyogenic, foreign body), urachal duct cyst, endometrioma, keloid, hernia and epithelial inclusion cyst.

Given the patient's age, a malignancy was the primary concern. The physical examination was nonfocal for a source of metastatic disease. A punch biopsy of the lesion was performed and revealed a poorly differentiated adenocarcinoma in the superficial and deep dermis. Computed tomography (CT) of the chest, abdomen and pelvis (Figure 2) showed diffuse caking of the omentum with tumor metastases and extension of the tumor into the periumbilical region. Additionally, the CT scan revealed two hypodense areas in the liver and a 15-mm nodule in the lower lobe of the right lung, suspicious for metastatic disease. The patient had no history of breast cancer, and mammography showed no evidence of breast carcinoma as a primary site for her metastatic disease. Upper endoscopy and colonoscopy were negative, and the patient's carcinoembryonic antigen level was measured as 1.1 ng per mL (normal range, 1 to 3 ng per mL). Further testing with immunohistochemical and receptor stains was inconclusive. No primary tumor was ever identified.

FIGURE 2.

Computed tomographic scan. Note the caking of the omentum (dashed outline) and tumor metastases and extension into the periumbilical region (arrow).

View Large


FIGURE 2.

Computed tomographic scan. Note the caking of the omentum (dashed outline) and tumor metastases and extension into the periumbilical region (arrow).


FIGURE 2.

Computed tomographic scan. Note the caking of the omentum (dashed outline) and tumor metastases and extension into the periumbilical region (arrow).

Sister Joseph (1856–1939), superintendent of St. Mary's Hospital, was credited with making the observation of lymphatic metastases to the umbilical region in metastatic tumors of intra-abdominal origin, hence the name “Sister Joseph's nodule.”1 Indeed, the primary tumor in most cases of Sister Joseph's nodule is intra-abdominal: stomach, large and small intestine, pancreas, kidney, uterus, ovary or gallbladder.24 Additionally, there are rare reports of primary tumors outside the abdominal cavity with metastasis to the umbilicus, including breast, lung and penis.2 In an estimated 9 to 17 percent of cases, the primary tumor is never found.2,4 In summary, Sister Joseph's nodule is a rare but important clinical finding. Although generally a poor prognostic sign, long-term survival may be possible if the nodule represents a solitary metastasis.2,4,5

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense or the United States Army.

REFERENCES

1. Schwartz IS. Sister (Mary?) Joseph's nodule. N Engl J Med. 1987;316:1348–9.

2. Dubreuil A, Dompmartin A, Barjot P, Louvet S, Leroy D. Umbilical metastasis or Sister Mary Joseph's nodule. Int J Dermatol. 1998;37:7–13.

3. Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29:228–36.

4. Powell FC, Cooper AJ, Massa MC, Goellner JR, Su WP. Sister Mary Joseph's nodule: a clinical and histologic study. J Am Acad Dermatol. 1984;10:610–5.

5. Sharaki M, Abdel-Kader M. Umbilical deposits from internal malignancy (the Sister Joseph's nodule). Clin Oncol. 1981;7:351–5.

The editors of AFP welcome submissions for Photo Quiz. Guidelines for preparing and submitting a Photo Quiz manuscript can be found in the Authors' Guide at http://www.aafp.org/afp/photoquizinfo. To be considered for publication, submissions must meet these guidelines. E-mail submissions to afpphoto@aafp.org.


Copyright © 2000 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact afpserv@aafp.org for copyright questions and/or permission requests.

Want to use this article elsewhere? Get Permissions


Article Tools

  • Print page
  • Share this page
  • AFP CME Quiz

Information From Industry

More in Pubmed

Navigate this Article