Cover	1064	1119

	Articles
1013	Sickle Cell Disease in Childhood: Part I. Laboratory Diagnosis, Pathophysiology and Health Maintenance DORIS L. WETHERS, M.D. Newborns at risk for sickle cell disease should be screened before two months of age to ensure the early institution of lifesaving preventive measures. Prophylactic penicillin initiated soon after birth, as well as the timely administration of Haemophilus influenzae type b and pneumococcal vaccines, reduces the incidence of H. influenzae and pneumococcal sepsis.
	Patient information: "Patient information: "Sickle Cell Disease," p. 1027
1035	Practical Therapeutics Primary Care Treatment of Post-traumatic Stress Disorder JENNIFER TRAVIS LANGE, CAPT, MC, USA, CHRISTOPHER L. LANGE, CAPT, MC, USA, and REX B.G. CABALTICA, M.D. The psychologic sequelae of trauma known as post-traumatic stress disorder can affect a wide range of patients seen in family practice. With early identification of persons at risk of this disorder, the symptoms can be prevented or treatment started immediately.
	Patient information: "Post-traumatic Stress Disorder--What It Is and What It Means to You," p. 1046
1051	Cover Article Alternative Therapies: Part I. Depression, Diabetes, Obesity VINCENT MORELLI, M.D., and ROGER J. ZOOROB, M.D., M.P.H. Certain natural supplements may be helpful in the management of common medical conditions, but careful selection of patients and knowledge of side effects are critical components in effective use. In the first part of this two-part article, the role of natural supplements in the management of depression, diabetes and obesity is discussed.
1064	Cervical Spondylotic Myelopathy: A Common Cause of Spinal Cord Dysfunction in Older Persons WILLIAM F. YOUNG, M.D. Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction in older persons. Although treatment guidelines remain controversial, many patients respond to surgical decompression of the spinal cord.
	Patient information: "Cervical Spondylotic Myelopathy (CSM)," p. 1073
1079	Polycystic Ovary Syndrome: It's Not Just Infertility MELISSA H. HUNTER, M.D., and JAMES J. STERRETT, PHARM.D. Polycystic ovary syndrome is the most common cause of anovulatory infertility. Treatment goals include symptom management and the identification and prevention of potential cardiovascular risks. The patient's desire for fertility is also an important consideration.
	Patient information: "Polycystic Ovary Syndrome," p. 1090
1095	Problem-Oriented Diagnosis Diagnosis of Vaginitis MARI E. EGAN, M.D., and MARTIN S. LIPSKY, M.D. The most common causes of vaginitis are bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis. A saline wet-mount preparation, a potassium hydroxide preparation, a litmus test for vaginal pH and a whiff test can help distinguish these infections.
1109	A Practical Approach to Uncomplicated Seizures in Children GARY N. MCABEE, D.O., J.D. and JAMES E. WARK, M.D. Febrile seizures, rolandic seizures and video game­related seizures are typically not associated with lesions on brain scans and may not require medication. Juvenile myoclonic epilepsy does not require neuroimaging but requires medication; complex partial epilepsy often requires neuroimaging and medical treatment.
1119	Cushing's Disease: Clinical Manifestations and Diagnostic Evaluation LAWRENCE F. KIRK, JR., M.D., ROBERT B. HASH, M.D., HAROLD P. KATNER, M.D., and TOM JONES, M.D. A 24-hour urine collection with analysis for urinary free cortisol excretion is the best screening test, but dexamethasone suppression tests and other methods may be required for a definitive diagnosis.
	Patient information: "Cushing's Syndrome and Cushing's Disease," p. 1133

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