Cover	1513	1517

	Articles
1555	Cover Article: End-of-Life Care Withholding and Withdrawing Life-Sustaining Treatment RICHARD J. ACKERMANN, M.D. Family physicians struggle with helping patients and families make end-of-life care decisions. Withholding and withdrawing life-sustaining treatment is appropriate and ethical in many situations.
	Patient information: "Artificial Fluids and Nutrition," p. 1562 "Cardiopulmonary Resuscitation (CPR)," p. 1564
1565	Problem-Oriented Diagnosis Anemia in the Elderly DOUGLAS L. SMITH, M.D. Serum ferritin is the most useful test for differentiating iron deficiency anemia from anemia of chronic disease. Determination of the serum methylmalonic acid level may be useful in the diagnosis of vitamin B12 deficiency.
1575	Practical Therapeutics Treating Fibromyalgia PAUL J. MILLEA, M.D., M.S., and RICHARD L. HOLLOWAY, PH.D. Fibromyalgia is a common chronic condition that is usually best managed with low-dose antidepressant therapy and exercise.
	Patient Information: "Information for Patients Living with Fibromyalgia," p. 1587
1591	Generalized Anxiety Disorder MICHAEL F. GLIATTO, M.D. Generalized anxiety disorder is a common condition that may present significant diagnostic and therapeutic challenges for family physicians.
	Patient information: "What You Should Know About Generalized Anxiety Disorder," p. 1602
1607	Clinical Pharmacology A Family Physician's Guide to Monitoring Methotrexate KELLY W. JONES, PHARM.D., and SUPEN R. PATEL, M.D. Methotrexate is used in the treatment of various immunologic diseases, such as psoriasis and rheumatoid arthritis. Although methotrexate is often prescribed by subspecialists, family physicians may assume responsibility for monitoring therapy with this highly effective but potentially toxic drug.
	Patient information: "Taking Methotrexate," p. 1614

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