Treating Obstructive Sleep Apnea Improves Essential Hypertension and Quality of Life



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About one half of patients who have essential hypertension have obstructive sleep apnea, and about one half of patients who have obstructive sleep apnea have essential hypertension. A growing body of evidence suggests that obstructive sleep apnea is a major contributing factor in the development of essential hypertension. Despite many patients with obstructive sleep apnea having clear symptoms of the disorder, an estimated 80 to 90 percent of cases are undiagnosed. When physicians routinely seek the diagnosis of obstructive sleep apnea by asking patients (especially those with hypertension) three basic sleep-related questions about snoring, excessive daytime sleepiness and reports of witnessed apneic events, the number of cases diagnosed and treated increases by about eightfold. Eliminating snoring and occurrences of apneic-hypopneic episodes will dramatically improve patients' quality of sleep and eliminate excessive daytime sleepiness, which has a detrimental effect on general functioning. Increased alertness will reduce the likelihood that patients will be involved in motor vehicle crashes. In most studies in which blood pressure was measured following treatment for obstructive sleep apnea, daytime and nighttime blood pressure levels were found to decrease significantly. This decrease in blood pressure may also reduce the likelihood of cardiovascular complications. The key to the diagnosis of obstructive sleep apnea is physician knowledge about the disorder. The dramatic improvement in quality of life that occurs when patients are successfully treated for obstructive sleep apnea makes detecting and treating this disorder imperative.

Obstructive sleep apnea (OSA), defined as an average of at least 10 apneic and hypopneic episodes per sleep hour, is a common sleep-related breathing disorder that leads to excessive daytime sleepiness because of marked fragmentation of sleep. Patients are frequently not diagnosed despite years of being symptomatic (especially with hypersomnolence), because physicians do not routinely look for the disorder. Additionally, the role of OSA in the production of essential hypertension (EH) is frequently not appreciated.14 The purpose of this article is to demonstrate how commonly OSA occurs, how the quality of patients' lives can improve with successful treatment, and how the disorder is related to EH.

OSA is characterized by a repetitive partial (hypopnea) or complete (apnea) closing of, apneas or hypopneas that last a minimum of 10 seconds are considered clinically significant, although they usually last from 20 to 30 seconds and can last more than one minute. Most of these episodes end when the patient wakes up slightly, almost always without being aware of it. This “arousal response” causes the airway to reopen. In severe cases, the cycle of opening and closing of the pharynx can recur 400 to 600 times a night.

The apnea-hypopnea index (AHI), also called the respiratory disturbance index, is the average number of apneas and hypopneas that occur per sleep hour. Although different thresholds exist for defining OSA, it is often defined as an AHI of 10 or more. The prevalence of OSA depends on how it is defined. When using the definition of an AHI of 10 or more, about 10 percent of persons 30 to 60 years of age (5 percent of women and 15 percent of men) have OSA.5 However, if OSA is defined as an AHI of five or more and the primary symptom of hypersomnolence is present, OSA is present in 2 percent of women and 4 percent of men between 30 and 60 years of age.5 A patient with an AHI of 40 or more is generally considered to have severe OSA.

Diagnosing OSA

The first question to ask patients suspected of having OSA is if they snore and, if so, whether they snore loudly or quietly, frequently or infrequently, and only when lying on their back or when lying on their side. In most cases, patients cannot hear their own snoring. Even if they admit to being told that they snore, patients often have a tendency to underestimate the loudness and frequency of their snoring. Snoring marked by frequent changes in loudness and frequency (as opposed to quiet and steady snoring) is highly suggestive of OSA. A bed partner or person in the household may be needed to give an accurate description of the patient's snoring. If the patient lives alone, a tape recorder can be placed near the bed and used to record hours of sleep to assess snoring.

The second question related to OSA is if patients have excessive daytime sleepiness. Patients may have difficulty describing their sleepiness and may call it “tiredness” or “fatigue.” Physicians should ask patients exactly what they mean, and they may have to ask directly, “Do you mean you are sleepy most of the time?” Patients may then volunteer that they wake up feeling sleepy and remain uncontrollably sleepy throughout the day, especially when engaging in passive activities (e.g., reading, watching television, or even driving an automobile).

A patient's spouse or bed partner can usually describe the sleep behavior much better than the patient. It is crucial, therefore, that a bed partner be present during the interview. While patients may report being “a little sleepy,” persons who live with patients may describe them as being very sleepy. If asked, patients may admit to having had one or more motor vehicle crashes or near crashes because of lack of attentiveness or falling asleep while driving. Patients who have OSA have a significantly greater chance of having a motor vehicle crash when compared with persons who do not have OSA.6 Excessive daytime sleepiness may also manifest as difficulty concentrating, remembering things, or thinking clearly. Other causes of sleepiness such as sleep deprivation, shift work, depression, hypothyroidism, or use of sleeping pills, sedatives, or excessive alcohol should be eliminated. Other sleep disorders, such as narcolepsy, should be ruled out.

Successful treatment of OSA will eliminate apneic and hypopneic breathing episodes, snoring, and the arousal responses caused by these respiratory events. Patients usually regain restful, uninterrupted sleep, which should dramatically improve their alertness during daytime hours. Also, patients' chances of being involved in motor vehicle crashes will be greatly reduced.6

The third question to ask (which should be directed to the bed partner, if possible) is whether the patient has episodes during sleep when breathing stops. The bed partner may describe periods of loud snoring by the patient followed by silence or a total absence of breathing lasting a few seconds up to one minute or longer. At the moment patients arouse from the apneic episode and the airway is opened, they usually take several deep, loud, gasping breaths that may be accompanied by gross body movements. The noise and body movements may awaken the bed partner.

Besides asking the three preceding questions, another useful question to ask is if the patient has a dry mouth on waking during the night or in the morning. Most heavy snorers and patients with OSA have a dry mouth because they usually breathe through their mouth when they sleep.

Another factor in the presence of OSA is nocturia, which is present in about one third of patients. Apneic episodes cause an increase in secretion of atrial natriuretic factor, which causes diuresis throughout the night. What may appear to be a prostatic problem may actually be diuresis caused by OSA. The nocturia may disappear with successful treatment of OSA.7

Hypertension is another major indicator of the presence of OSA because about one half of patients with EH have OSA, and about one half of all patients with OSA have EH.14 In fact, in the last two years, seven major studies814 have shown that OSA is an independent risk factor for hypertension and, generally, the more severe the OSA, the more prevalent and severe the hypertension. In addition, many studies,14 including four that have been recently published,1518 have shown that successful treatment of OSA is associated with a significant reduction in blood pressure levels, although two other studies19,20 did not report similar findings. A recent long-term study21 also showed that normotensive patients with OSA are far more likely to develop hypertension over a four-year period than those without OSA.

If ambulatory blood pressure monitoring indicates that a patient is a “nondipper” (i.e., blood pressure during sleep fails to fall, or “dip,” by at least 10 percent as it normally does when compared with the mean awake blood pressure level), then the chances that the patient has OSA are increased.22

Obesity is a major indicator of the presence of OSA. Many patients with OSA may report a recent weight gain along with an increase in snoring and sleepiness. The risk of OSA is particularly high in patients who are obese and who have a large neck circumference and central obesity (i.e., a large waist-to-hip ratio). Although about 70 percent of patients with OSA are obese, thin people also can have OSA.

OSA can be worsened by sleep deprivation, alcohol intake, smoking, use of central nervous system depressants, and chronic nasal congestion.

Missed Diagnosis

Eighty to 90 percent of patients with OSA are undiagnosed, despite having clear signs and symptoms.23,24 When patients are finally diagnosed with OSA, they have had obvious symptoms of the disorder for an average of seven years, during which time they report having seen a family physician about 17 times and a subspecialist about nine times.25 The most likely reason for missed diagnosis is that physicians simply do not suspect sleep apnea. Studies have shown that when physicians are informed about the disorder, their index of suspicion is high and they routinely ask their patients about OSA symptoms,26 which increases the numbers of patients diagnosed and treated in their practices by about eightfold.27

OSA As a Major Contributing Factor in EH

Evidence that OSA can cause elevated blood pressure levels during sleep and during the day is very strong (Table 1).14,823,2833  Not only are OSA and EH clinically similar but also, as shown in Table 2,14 the physiologic, biochemical and hematologic characteristics that contribute to the persistence of hypertension are similar. Therefore, in many cases, OSA and EH appear to be the same condition.1

TABLE 1

Evidence That OSA Causes Hypertension and Contributes to Essential Hypertension

About 50% (range 30 to 80%) of patients with EH have OSA.

About 50% of patients with OSA have EH.

In patients with OSA, mean blood pressure during sleep often fails to fall as it normally does during sleep, but remains at a level similar to the awake blood pressure. This “non-dipping” is caused by frequent apneic/hypopneic episodes (up to 600 per night) ending with arousals that are associated with marked spikes in blood pressure that last for several seconds.

One third of patients with EH have blood pressure levels during sleep that fail to fall normally (i.e., they are non-dippers). Ninety percent of these patients have been found to have OSA.

Multiple studies have shown that OSA is an independent risk factor for the presence of EH even when considering age, gender, and degree of obesity.

Patients who are normotensive and who have OSA are much more likely to develop EH during the next few years than those without OSA.

The more severe the OSA, the higher the blood pressure levels and the greater the prevalence of EH.

Numerous studies have shown that treatment of OSA by CPAP or position therapy lowers the awake and 24-hour blood pressure levels.

In persons successfully treated with CPAP, cessation of treatment causes blood pressure levels to increase, while restarting treatment causes blood pressure levels to fall again.

The more severe the OSA, the more difficult it becomes to control blood pressure levels with medications.

In animal studies, the production of OSA causes sleeping and awake systemic hypertension to develop within a few weeks, and the cessation of OSA causes blood pressure levels to return to normal within a few weeks.

Some evidence exists that habitual snoring, especially loud frequent snoring, even without OSA is associated with elevated blood pressure levels during the night and day, and that treatment with CPAP can lower blood pressure levels.


OSA = obstructive sleep apnea; EH = essential hypertension; CPAP = continuous positive airway pressure.

Information from references1 through4,8 through23 and28 through33.

TABLE 1   Evidence That OSA Causes Hypertension and Contributes to Essential Hypertension

View Table

TABLE 1

Evidence That OSA Causes Hypertension and Contributes to Essential Hypertension

About 50% (range 30 to 80%) of patients with EH have OSA.

About 50% of patients with OSA have EH.

In patients with OSA, mean blood pressure during sleep often fails to fall as it normally does during sleep, but remains at a level similar to the awake blood pressure. This “non-dipping” is caused by frequent apneic/hypopneic episodes (up to 600 per night) ending with arousals that are associated with marked spikes in blood pressure that last for several seconds.

One third of patients with EH have blood pressure levels during sleep that fail to fall normally (i.e., they are non-dippers). Ninety percent of these patients have been found to have OSA.

Multiple studies have shown that OSA is an independent risk factor for the presence of EH even when considering age, gender, and degree of obesity.

Patients who are normotensive and who have OSA are much more likely to develop EH during the next few years than those without OSA.

The more severe the OSA, the higher the blood pressure levels and the greater the prevalence of EH.

Numerous studies have shown that treatment of OSA by CPAP or position therapy lowers the awake and 24-hour blood pressure levels.

In persons successfully treated with CPAP, cessation of treatment causes blood pressure levels to increase, while restarting treatment causes blood pressure levels to fall again.

The more severe the OSA, the more difficult it becomes to control blood pressure levels with medications.

In animal studies, the production of OSA causes sleeping and awake systemic hypertension to develop within a few weeks, and the cessation of OSA causes blood pressure levels to return to normal within a few weeks.

Some evidence exists that habitual snoring, especially loud frequent snoring, even without OSA is associated with elevated blood pressure levels during the night and day, and that treatment with CPAP can lower blood pressure levels.


OSA = obstructive sleep apnea; EH = essential hypertension; CPAP = continuous positive airway pressure.

Information from references1 through4,8 through23 and28 through33.

Some evidence suggests that OSA may also be an important contributor in the development of coronary heart disease, stroke, cardiac arrhythmia, and congestive heart failure,34 because about one half of all patients with coronary heart disease,35 stroke,36 and congestive heart failure37 have OSA. Additionally, retrospective studies have shown that successful treatment of OSA is associated with a marked reduction in hospitalization38 and mortality,39 and prospective studies have shown that successful treatment of OSA improves nocturnal angina,40 nocturnal cardiac arrythmia,41 and congestive heart failure.42

TABLE 2

Similarities Between Obstructive Sleep Apnea and Essential Hypertension

Epidemiologic findings

Increased prevalence of obesity and central obesity

More common in middle-aged men than women

More common in older than younger women

More common in blacks than whites

More common in persons who abuse alcohol (Alcohol is an important cause of hypertension and can worsen OSA and snoring.)

Genetic characteristics

A similar hereditary pattern is present in OSA and EH

Clinical findings

Improve with weight loss

Increased prevalence of snoring, cardiovascular complications, renal damage, cognitive dysfunction, headaches, impotence, non-dipping blood pressure levels during sleep, increased blood pressure variability, diabetes and insulin resistance

Hematologic and biochemical findings

Elevated hematocrit

Hyperuricemia

Reduced renin levels during sleep

Increased sympathetic activity

Elevated atrial natriuretic factor

Elevated ratio of vasoconstrictor to vasodilator prostaglandins

Reduced testosterone levels in men

Reduced endothelium dependent relaxation factor (nitric oxide)

Reduced blood fibrinolytic activity

Increased platelet activation and aggregation

Elevated erythropoietin levels

Elevated plasma fibrinogen levels

Elevated endothelin

Elevated leptin levels

Elevated von Willebrand factor

Physiologic responses

Increased chemoreceptor sensitivity as seen by exaggerated pressor response and ventilation response to hypoxia

Reduced baroreceptor sensitivity


Information from references1 through4.

TABLE 2   Similarities Between Obstructive Sleep Apnea and Essential Hypertension

View Table

TABLE 2

Similarities Between Obstructive Sleep Apnea and Essential Hypertension

Epidemiologic findings

Increased prevalence of obesity and central obesity

More common in middle-aged men than women

More common in older than younger women

More common in blacks than whites

More common in persons who abuse alcohol (Alcohol is an important cause of hypertension and can worsen OSA and snoring.)

Genetic characteristics

A similar hereditary pattern is present in OSA and EH

Clinical findings

Improve with weight loss

Increased prevalence of snoring, cardiovascular complications, renal damage, cognitive dysfunction, headaches, impotence, non-dipping blood pressure levels during sleep, increased blood pressure variability, diabetes and insulin resistance

Hematologic and biochemical findings

Elevated hematocrit

Hyperuricemia

Reduced renin levels during sleep

Increased sympathetic activity

Elevated atrial natriuretic factor

Elevated ratio of vasoconstrictor to vasodilator prostaglandins

Reduced testosterone levels in men

Reduced endothelium dependent relaxation factor (nitric oxide)

Reduced blood fibrinolytic activity

Increased platelet activation and aggregation

Elevated erythropoietin levels

Elevated plasma fibrinogen levels

Elevated endothelin

Elevated leptin levels

Elevated von Willebrand factor

Physiologic responses

Increased chemoreceptor sensitivity as seen by exaggerated pressor response and ventilation response to hypoxia

Reduced baroreceptor sensitivity


Information from references1 through4.

The Role of OSA in Secondary Hypertension

Some evidence suggests that OSA may also contribute to hypertension associated with hypothyroidism, acromegaly, alcohol abuse, and chronic renal failure.1

Diagnostic Evaluation of OSA

Several reviews43,44  have been published about the diagnosis and physical examination of patients with OSA. The common physical findings in OSA are listed in Table 3.43,44 Because many patients with OSA have an upper airway abnormality, an ear, nose and throat evaluation is essential in the diagnostic workup.

TABLE 3

Common Physical Findings in OSA

Obesity

Primarily central obesity as assessed by an increased waist-to-hip ratio

Short neck and increased neck circumference

On oral examination

No clear abnormalities present in some cases

Crowded mouth with low-extending soft palate sometimes present

Large uvula

Generalized erythema and swelling of all tissues including the pharyngeal pillars

Large tonsils and adenoids may be present, especially in children

Large tongue (macroglossia)

High, arched and narrow hard palate (causes a narrow and crowded mouth)

Overbite of upper teeth

Retrognathia or micrognathia

Obstructed nasal passages

Evidence of hypothyroidism and acromegaly


Information from references43 and44.

TABLE 3   Common Physical Findings in OSA

View Table

TABLE 3

Common Physical Findings in OSA

Obesity

Primarily central obesity as assessed by an increased waist-to-hip ratio

Short neck and increased neck circumference

On oral examination

No clear abnormalities present in some cases

Crowded mouth with low-extending soft palate sometimes present

Large uvula

Generalized erythema and swelling of all tissues including the pharyngeal pillars

Large tonsils and adenoids may be present, especially in children

Large tongue (macroglossia)

High, arched and narrow hard palate (causes a narrow and crowded mouth)

Overbite of upper teeth

Retrognathia or micrognathia

Obstructed nasal passages

Evidence of hypothyroidism and acromegaly


Information from references43 and44.

The gold standard for an accurate diagnosis of OSA is a polysomnography evaluation performed in a sleep disorders unit. During this overnight evaluation, the number of apneas and hypopneas can be quantified, their duration measured, their relationship to body position and sleep stages determined, the level of oxygen desaturation measured and the existence of arrhythmic episodes can be quantified. This information determines the severity of the disorder and helps determine the treatment choice. Other tests often performed to objectively evaluate daytime sleepiness include the Multiple Sleep Latency Test and the Maintainence of Wakefulness Test.

Treatment of OSA

Treatment of OSA includes nonsurgical and surgical approaches.4554 No successful pharmacologic treatment currently exists for snoring or OSA.

NONSURGICAL PROCEDURES

Weight Loss

Weight loss should always be strongly encouraged in patients with OSA who are obese (about 70 percent of all patients who have OSA are obese). Weight loss can produce good results and even small reductions in weight can produce major improvements in OSA.46,47 Because compliance with this treatment is usually poor,46 physicians should not delay initiating other forms of therapy unless patients are making serious attempts to reduce their weight.

Continuous Positive Airway Pressure (CPAP)

During sleep, room air is continuously applied by a small, quiet air compressor that delivers positive pressure through a nasal mask. The CPAP system acts as a physical pressure splint to prevent partial or complete collapse of the upper airway during sleep. CPAP is the treatment of choice for patients with moderate to severe OSA, but it is also used to treat patients with mild OSA and those with loud and continuous snoring.

While CPAP is an extremely effective form of therapy, there are two pitfalls in its use. It is not a permanent cure; when patients stop treatment, OSA returns within a few days. Secondly, because patients may be reluctant to attempt CPAP or persist in using it, family physicians should encourage and closely follow patients because the beneficial effects on quality of life can be great.45,48

Position Therapy (Avoiding the Supine Position)

A large study49 of patients with OSA who were diagnosed in a sleep disorders unit recently demonstrated that “positional patients” (those who have more than twice as many abnormal breathing episodes when sleeping in the supine position than when sleeping in the lateral position) represent more than one half of patients with OSA. These patients, in most cases, were found to have mild OSA. These results were not surprising because, when lying in the lateral position, patients have significantly fewer breathing abnormalities than when lying in the supine position. In some instances, a total absence of breathing disturbances was observed when patients were lying in the lateral position. For these patients and those who had an AHI of 10 or less while lying in the lateral position, position therapy represented a valuable and effective therapy.

Results from another study50 showed that patients with OSA who were hypertensive and normotensive and who avoided sleeping in the supine position for one month by using the tennis ball technique, a simple and inexpensive behavioral method, had a significant reduction in 24-hour blood pressure values and blood pressure variability. (In the tennis ball technique, a wide cloth belt with a pocket that a tennis ball is placed into is worn around the chest so that the pocket with the ball is positioned in the middle of the back. When the patient rolls onto his or her back, the pressure of the tennis ball causes the patient to roll onto their side again.) If these preliminary results are confirmed in larger studies, avoiding the supine position during sleep could become a new nonpharmacologic treatment for many hypertensive patients.

Oral Devices

Oral devices placed in the mouth at bedtime to keep the mandible and tongue in a forward position during sleep can prevent upper airway obstruction during sleep. This therapy has been shown to be useful primarily in patients with simple snoring and in patients with mild to moderate OSA.51

SURGICAL PROCEDURES

A wide variety of surgical procedures are currently used to treat OSA and, of these, uvulopalatopharyngoplasty is the most common. This procedure can be performed using conventional or laser techniques. Unfortunately, only about 40 to 60 percent of patients who have OSA show an improvement in symptoms following the procedure, and it is impossible to predict which patients will benefit from surgery and which will not. Other surgical procedures include relief of nasal obstruction, tonsillectomy, adenoidectomy, mandibular-maxillary surgery, and, most recently, somnoplasty, in which radiofrequency energy is used to shrink part of the tongue and soft palate.5254

The Authors

DONALD S. SILVERBERG, M.D., is a senior nephrologist in the department of nephrology at Tel Aviv Medical Center, Tel Aviv, Israel. He earned his medical degree from the University of Manitoba, Winnipeg, Canada. Dr. Silverberg completed residencies in internal medicine and nephrology at the Mayo Clinic, Rochester, Minn.

ARIE OKSENBERG, PH.D., is director of the Sleep Disorders Unit, Loewenstein Rehabilitation Hospital, Raanana, Israel. He earned his Ph.D. in physiology from the Biomedical Research Institute at the National University of Mexico (UNAM), Mexico City. Dr. Oksenberg completed a fellowship in sleep ontogeny at the University of Texas Health Science Center at Dallas, and a fellowship in sleep disorders at Presbyterian Hospital of Dallas.

ADRIAN IAINA, M.D., is an associate professor of medicine at the Tel Aviv University Medical School and head of the department of nephrology at Tel Aviv Medical Center Department of Nephrology, Tel Aviv Medical Center. Dr. Iaina earned his medical degree from the University of Medicine and Pharmacy, ClujNapoca, Romania and completed a residency in nephrology at the Tel Hashomer Hospital, Ramat Gan, Israel.

Address correspondence to Donald S. Silverberg, M.D., Department of Nephrology, Tel Aviv Medical Center, Weizman 6, Tel Aviv 64239, Israel (e-mail: donald@netvision.net.il). Reprints are not available from the authors.

The authors indicate that they do not have any conflicts of interest. Sources of funding: none reported.

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