Linezolid: Its Role in the Treatment of Gram-Positive, Drug-Resistant Bacterial Infections



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While the choices available for the management of gram-positive, drug-resistant bacterial infections are becoming limited, antimicrobial resistance is becoming increasingly problematic because of the widespread overuse of antibiotics. Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial growth by inhibiting the initiation process of protein synthesis—a mechanism of action that is unique to this class of drugs. It is well absorbed with high bioavailability that allows conversion to oral therapy as soon as the patient is clinically stable. It has been approved for certain gram-positive infections including certain drug-resistant enterococcus, staphylococcus, and pneumococcus strains. It is generally well tolerated, with myelosuppression being the most serious adverse effect. As a nonselective inhibitor of monoamine oxidase, caution is recommended when used with adrenergic or serotonergic agents (e.g., tyramine, dopamine, pseudoephedrine, and selective serotonin reuptake inhibitors). Judicious use of this medication should help physicians treat patients with multidrug-resistant infections.

The growing antimicrobial resistance of certain microorganisms is now a worldwide concern. The introduction of penicillin in 1944 was soon followed by reports of resistance to Staphylococcus aureus. Physicians have encountered problems with antimicrobial resistance ever since. During the 1970s, the problem of drug-resistant, gram-negative bacteria and of methicillin-resistant S. aureus emerged. Currently, the most pressing problem is that of multidrug-resistant, gram-positive bacteria.

Factors Responsible for Antimicrobial Resistance

Multiple factors contribute to the development of resistance to antibiotics. Their widespread and unnecessary use is the greatest contributing factor. It is estimated that 50 million pounds of antibiotics are taken annually in the United States1 and 30 percent of antibiotic prescriptions are for respiratory tract infections, more than one half of which were probably viral.2 The increasing problem of antimicrobial resistance in the hospital and the community parallels the over-prescribing of antibiotics. Other contributing factors that have led to changes in virulence, and thus, the development of resistance to antibiotics, include societal changes (e.g., population growth and migration), an increasing number of immunosuppressed patients, the globalization of food supplies and changes in the way food is grown and produced, human behavior (e.g., widespread and frequent international travel), and environmental changes (including long-standing use of antibiotics in animal husbandry and agriculture).3

Resistance Problems Among Gram-Positive Organisms

The increasing resistance among gram-positive species is concerning because they are responsible for one third of nosocomial infections.4 During the past two decades, the prevalence of methicillin-resistant S. aureus increased from 2.0 to 39.7 percent in the United States.5 Between 1980 and 1989, the incidence of bacteremia caused by coagulase-negative staphylococcal species, S. aureus, and enterococcus increased by 176 and 124 percent, respectively.6 These three pathogens are now the most common nosocomial-acquired causes of bacteremia. Surveillance data report that nearly 79 and 25 percent of nosocomially acquired, coagulase-negative staphylococcal species and S. aureus are methicillin-resistant, respectively.6

The enterococcus species is recognized as a major nosocomial pathogen. During the period of methicillin-resistant S. aureus emergence, enterococci became the third most common cause of nosocomial infections.5 In 1993, it was reported that 13.9 percent of all enterococcal isolates were resistant to vancomycin (Vancocin), representing a 20-fold increase from 1989.5 Previously, vancomycin was often considered the final therapeutic option in cases in which resistance to all other antibiotics was present. Unfortunately, the arrival of vancomycin-resistant enterococcus changed this approach. Between 1990 and 1997, the percentage of enterococcal species resistant to vancomycin increased from less than 1 percent to 18 percent.7 Enterococcus faecalis is responsible for 60 percent of these infections.8 A new threat of decreased susceptibility of S. aureus to vancomycin now exists.8 This emerging resistance to vancomycin is disturbing because it has been considered the last line of defense.

TABLE 1

Common, Antibiotic-Resistant Microorganisms

Community-acquired resistant Escherichia coli Haemophilus influenzae Methicillin-resistant Staphylococcus aureus Multidrug-resistant tuberculosis Neisseria gonorrhea Neisseria meningitidis Salmonella species Shigella species Streptococcus pneumoniae Streptococcus viridans

Nosocomial-resistant Bacteroides species Candida species Coagulase-negative staphylococci Enterobacter species Klebsiella species Methicillin-resistant S. aureus Multidrug-resistant tuberculosis Proteus species Pseudomonas aeruginosa Serratia species Vancomycin-resistant enterococci


Adapted with permission from Hawkes CA. Antibiotic resistance: a clinician's perspective. Mil Med 2000;165(7 suppl 2):43–5.

TABLE 1   Common, Antibiotic-Resistant Microorganisms

View Table

TABLE 1

Common, Antibiotic-Resistant Microorganisms

Community-acquired resistant Escherichia coli Haemophilus influenzae Methicillin-resistant Staphylococcus aureus Multidrug-resistant tuberculosis Neisseria gonorrhea Neisseria meningitidis Salmonella species Shigella species Streptococcus pneumoniae Streptococcus viridans

Nosocomial-resistant Bacteroides species Candida species Coagulase-negative staphylococci Enterobacter species Klebsiella species Methicillin-resistant S. aureus Multidrug-resistant tuberculosis Proteus species Pseudomonas aeruginosa Serratia species Vancomycin-resistant enterococci


Adapted with permission from Hawkes CA. Antibiotic resistance: a clinician's perspective. Mil Med 2000;165(7 suppl 2):43–5.

In the community setting, many antibiotic-resistant bacteria have emerged (Table 1).5 The prevalence of drug-resistant Streptococcus pneumoniae has increased 60-fold since 1980 with 51 percent and 8 percent of isolates demonstrating intermediate- or high-level resistance to penicillin or third-generation cephalosporins, respectively.9 Thus, pneumococcal pneumonia is becoming more difficult to treat with first-line agents.

It is important to control the emergence of antimicrobial resistance and minimize the inappropriate use of antibiotics through education. This is not a small task and requires a multidisciplinary approach. All health care professionals need to work toward the same goal. Some principles to control antimicrobial resistance are outlined in Table 2.5

Against this background, newer therapeutic options are now available. Linezolid (Zyvox), a novel antimicrobial agent, has been approved by the U.S. Food and Drug Administration (FDA) primarily to fight resistant gram-positive cocci, such as vancomycin-resistant enterococcus, methicillin-resistant S. aureus, and penicillin-resistant pneumococci. Antibiotic therapy for these resistant infections must be guided by laboratory testing; thus, appropriate cultures should be obtained to determine the causative organism(s) and its susceptibility to linezolid.

Mechanism of Action

Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial growth by inhibiting the initiation process in protein synthesis. This site of inhibition occurs earlier in the initiation process than other protein synthesis inhibitors (e.g., chloramphenicol [Chloromycetin], clindamycin [Cleocin], aminoglycosides, and macrolides) that interfere with the elongation process.10,11 Because the site of inhibition is unique to linezolid, cross-resistance to other protein synthesis inhibitors has not yet been reported.12 Linezolid may also inhibit virulence factor expression and decrease toxin production in gram-positive pathogens.13

It is preferable to use an agent possessing bactericidal properties when possible. It has been demonstrated that linezolid is bacteriostatic against enterococci and staphylococci, and bactericidal for the majority of streptococci.14

Pharmacokinetics

Linezolid is highly absorbed when administered orally, with a bioavailability of approximately 100 percent.15 This allows conversion from intravenous to oral therapy as soon as the patient is clinically stable; thus, it provides an advantage over comparative therapy that can be delivered only parenterally (i.e., vancomycin or quinupristin/dalfopristin [Synercid]). Linezolid is metabolized via hepatic oxidation without any cytochrome P-450 pathways. Elimination occurs through nonrenal, renal, and fecal mechanisms accounting for 65, 30, and 5 percent, respectively. The half-life is approximately five hours.15 Generally, the dosing interval for an antibiotic is three times the half-life—the dosing interval for linezolid is every 12 hours. Presently, no dosage adjustment is recommended for patients with renal insufficiency; however, linezolid is removed by hemodialysis and should be administered following dialysis.14,15

Indications

The FDA has approved linezolid for certain gram-positive infections in adult patients (Table 3).15 Other pathogens that linezolid has demonstrated in-vitro activity against include penicillin-resistant S. pneumoniae, vancomycin-sensitive E. faecalis, vancomycin-resistant E. faecalis, methicillin-susceptible Staphylococcus epidermidis and methicillin-resistant S. epidermidis, Corynebacterium sp, Moraxella catarrhalis, legionella species Listeria monocytogenes, Pasteurella multocida, and Bacteroides fragilis.10,16

Because of limited clinical data demonstrating activity against gram-negative organisms, it is recommended that coverage for these pathogens be added when indicated.15 Clinical data in other special patient populations (i.e., children, pregnant women, or breastfeeding mothers) are limited. Linezolid is a pregnancy category C drug, and caution is urged if used in breastfeeding mothers. The safety and efficacy, and an appropriate dosage have not been established in children younger than 18 years.15 Use in these patient populations cannot be recommended at this time.

TABLE 2

Principles to Control Antimicrobial Resistance

Appropriate antimicrobial use

Optimal use of antimicrobial agents—whether therapeutic, prophylactic, or empiric

Restriction of certain antimicrobial agents

Rotation of antimicrobial therapy

Combination of antimicrobial therapy

Implementation of guidelines for common antibiotic use

Antimicrobial resistance surveillance programs

Prompt detection and reporting of new resistance patterns

Rapid detection of resistant organisms

Physicians and paramedical staff education

Computer-based monitoring and feedback on use of microbial agents

Multidisciplinary approach in controlling antimicrobial resistance

Professional review of hospitals by oversight agencies such as the Joint Commission on Accreditation of Healthcare Organizations


Reproduced with permission from Hawkes CA. Antibiotic resistance: a clinician's perspective. Mil Med 2000;165(7 suppl 2):43–5.

TABLE 2   Principles to Control Antimicrobial Resistance

View Table

TABLE 2

Principles to Control Antimicrobial Resistance

Appropriate antimicrobial use

Optimal use of antimicrobial agents—whether therapeutic, prophylactic, or empiric

Restriction of certain antimicrobial agents

Rotation of antimicrobial therapy

Combination of antimicrobial therapy

Implementation of guidelines for common antibiotic use

Antimicrobial resistance surveillance programs

Prompt detection and reporting of new resistance patterns

Rapid detection of resistant organisms

Physicians and paramedical staff education

Computer-based monitoring and feedback on use of microbial agents

Multidisciplinary approach in controlling antimicrobial resistance

Professional review of hospitals by oversight agencies such as the Joint Commission on Accreditation of Healthcare Organizations


Reproduced with permission from Hawkes CA. Antibiotic resistance: a clinician's perspective. Mil Med 2000;165(7 suppl 2):43–5.

Dosing

The dosage regimen for linezolid is 400 mg or 600 mg every 12 hours for a duration of 10 to 28 days, with an intravenous or oral route of administration, based on the indication (Table 4).14 The 400-mg dose is approved for uncomplicated skin or skin structure infections; however, because many other antibiotic therapies are available, the authors strongly discourage the use of linezolid for this indication in order to reduce the potential for developing bacterial resistance. The intravenous infusion should be administered over a period of 30 to 120 minutes.14 Several incompatibilities have been reported: amphotericin B (Fungizone), ceftriaxone (Rocephin), chlorpromazine (Thorazine), diazepam (Valium), erythromycin, phenytoin (Dilantin), and trimethoprim-sulfamethoxazole (Bactrim).17 Because compatibility information changes, it is recommended that a pharmacist be consulted when there is doubt.

Adverse Effects

Adverse effects reported in clinical trials in more than 2 percent of patients include the following: rash, headache, diarrhea, nausea, vomiting, insomnia, constipation, and fever.15 The incidence was similar to the comparator groups: ceftriaxone, clarithromycin (Biaxin), dicloxacillin (Pathocil), oxacillin (Bactocill), and vancomycin.

TABLE 3

FDA Indications for Use of Linezolid

Vancomycin-resistant Enterococcus faecium, including cases with concurrent bacteremia

Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and resistant strains) or Streptococcus pneumoniae (penicillin-susceptible strains only)

Complicated skin and skin structure infections caused by S. aureus (methicillin-susceptible and resistant strains), Streptococcus pyogenes, Streptococcus agalactiae

Uncomplicated skin and skin structure infections caused by S. aureus (methicillin-susceptible strains only) or S. pyogenes

Community-acquired pneumonia caused by S. pneumoniae (penicillin-susceptible strains only), including cases with concurrent bacteremia, or S. aureus (methicillin-susceptible strains only)


Information from Zyvox (linezolid). Package insert. Peapack, N.J.: Pharmacia & Upjohn. Retrieved May 2001, from: www.zyvox.com/pdfs/zyvox_full_prescribe_012001.pdf.

TABLE 3   FDA Indications for Use of Linezolid

View Table

TABLE 3

FDA Indications for Use of Linezolid

Vancomycin-resistant Enterococcus faecium, including cases with concurrent bacteremia

Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and resistant strains) or Streptococcus pneumoniae (penicillin-susceptible strains only)

Complicated skin and skin structure infections caused by S. aureus (methicillin-susceptible and resistant strains), Streptococcus pyogenes, Streptococcus agalactiae

Uncomplicated skin and skin structure infections caused by S. aureus (methicillin-susceptible strains only) or S. pyogenes

Community-acquired pneumonia caused by S. pneumoniae (penicillin-susceptible strains only), including cases with concurrent bacteremia, or S. aureus (methicillin-susceptible strains only)


Information from Zyvox (linezolid). Package insert. Peapack, N.J.: Pharmacia & Upjohn. Retrieved May 2001, from: www.zyvox.com/pdfs/zyvox_full_prescribe_012001.pdf.

Thrombocytopenia, defined as a decrease in platelet count below 75 percent of normal or baseline, was reported in 2.4 percent of patients receiving linezolid versus 1.5 percent in those in the comparator group.14 This effect may be associated with the higher dose or treatment duration exceeding two weeks.

In addition, the FDA has recently reported cases of myelosuppression (anemia, leukopenia, and pancytopenia) warranting the monitoring of hematologic parameters and has issued a warning that myelosuppression is considered a potential adverse effect. The current recommendation is to monitor complete blood count status weekly, especially in patients receiving therapy longer than two weeks' duration, those with preexisting myelosuppression, those receiving drugs that produce bone marrow suppression, and those with a chronic infection who have received other antibiotic therapy recently or concurrently. If myelosuppression occurs, then discontinuation of therapy should be considered.

Drug-Drug Interactions

Linezolid does not affect cytochrome P-450; therefore, induced interactions are unlikely to occur.10,11 No pharmacokinetic interaction was observed in patients taking warfarin (Coumadin) or phenytoin.15

Linezolid is a reversible, nonselective inhibitor of monoamine oxidase (MOA), and a potential interaction with adrenergic or serotonergic agents is possible. A significant pressor response was observed when administered with tyramine; therefore, patients should avoid consuming food or beverages containing tyramine.14,15 More commonly used agents such as dopamine (Intropin), epinephrine, or decongestants containing pseudoephedrine may also produce an exaggerated pressor response. In healthy normotensive subjects receiving linezolid and pseudo-ephedrine, the mean maximum increase in systolic blood pressure was 32 mm Hg.11 Maximum elevation occurred at two to three hours and returned to baseline within three hours. No affect on heart rate was observed. Careful dosing titration is recommended when initiating dopamine or epinephrine.14

The potential for a serotonergic interaction with dextromethorphan (Robitussin DM) was evaluated in healthy subjects. No serotonin syndrome effects (confusion, delirium, tremors, restlessness, hyperpyrexia, or diaphoresis) were observed with this combination.14 No effects of serotonin syndrome were observed during a phase III study of 52 patients comparing fluoxetine, paroxetine and sertraline with linezolid.18 Nevertheless, caution is therefore recommended when using linezolid with agents such as citalopram (Celexa), fluvoxamine (Luvox), fluoxetine (Prozac), paroxetine (Paxil), or sertraline (Zoloft) until clinical safety is demonstrated.14,15

Clinical Studies

The FDA approved linezolid on the basis of nine unpublished, controlled clinical trials involving more than 4,000 patients.19 Most published trials are either in-vitro studies or clinical studies involving a small sample size.

In all the therapeutic trials thus far, the 600-mg dosage was consistently more effective in the treatment of patients with vancomycin-resistant enterococcus infections than was the 200-mg dosage. Intravenous linezolid at twice daily dosages of 600 mg produced a clinical cure rate of 88.6 percent compared with 73.7 percent in the patients with vancomycin-resistant enterococcus infections who received 200 mg daily.16

TABLE 4

Linezolid (Zyvox) Dosing Recommendations

Infection Dosage/route Recommended duration (days)

Nosocomial pneumonia

600 mg IV or PO every 12 hours

10 to 14

Complicated skin/skin structure infections

As above

As above

Community-acquired pneumonia, including concurrent bacteremia

As above

As above

Vancomycin-resistantEnterococcus faecium infections, including concurrent bacteremia

600 mg IV or PO every 12 hours

14 to 28

Uncomplicated skin/skin structure infections

400 mg PO every 12 hours

10 to 14


IV = intravenous; PO = oral

Reproduced with permission from Zyvox (linezolid) approved as super antibiotic, new treatment option for hospital-acquired and drug-resistant bacteria. Pharmacia Corporation: Peapack, N.J.: April 18, 2000.

TABLE 4   Linezolid (Zyvox) Dosing Recommendations

View Table

TABLE 4

Linezolid (Zyvox) Dosing Recommendations

Infection Dosage/route Recommended duration (days)

Nosocomial pneumonia

600 mg IV or PO every 12 hours

10 to 14

Complicated skin/skin structure infections

As above

As above

Community-acquired pneumonia, including concurrent bacteremia

As above

As above

Vancomycin-resistantEnterococcus faecium infections, including concurrent bacteremia

600 mg IV or PO every 12 hours

14 to 28

Uncomplicated skin/skin structure infections

400 mg PO every 12 hours

10 to 14


IV = intravenous; PO = oral

Reproduced with permission from Zyvox (linezolid) approved as super antibiotic, new treatment option for hospital-acquired and drug-resistant bacteria. Pharmacia Corporation: Peapack, N.J.: April 18, 2000.

Results from a compassionate use trial involving treatment of patients with bacteremia for resistant, gram-positive infections reveal that linezolid was well tolerated.20 By the fifth day of the study, 75 percent of the bacteremia had resolved. It was concluded that linezolid is an excellent option for the treatment of patients with significant, resistant gram-positive bacteremic infections.

Eighty-one patients with community-acquired pneumonia were treated with linezolid, resulting in a 98 percent cure rate.21 Of note, biologic eradication was achieved in all evaluated patients infected with S. pneumoniae. Linezolid demonstrated similar efficacy to ceftriaxone and/or cefpodoxime proxetil, with a clinical cure rate of approximately 90 percent for community-acquired pneumonia.16 Interestingly, linezolid was clinically and microbiologically superior to ceftriaxone in treating patients with concurrent bacteremia (93 percent in the linezolid group versus 69.9 percent in the ceftriaxone/cefpodoxime proxetil group).16

Linezolid (600 mg twice a day) and vancomycin (1 g twice a day) are similarly safe and efficacious in the treatment of patients with nosocomial pneumonia, including methicillin-resistant S. aureus. Patients were treated for seven to 21 days, with cure rates of 66.4 percent for patients treated with linezolid and 68.1 percent for patients treated with vancomycin.22

TABLE 5

Comparison of Linezolid (Zyvox) to Quinupristin/Dalfopristin (Synercid)

Drug/clinical significance Mechanism of action FDA-approved spectrum of activity Side-effect profile FDA-approved indications Dosage forms Daily cost ($)*

Linezolid

Inhibits protein synthesis at initiation step.

Streptococcus pneumoniae (penicillin sensitive); Staphylococcus aureus (MSSA and MRSA); Streptococcus pyogenes; Streptococcus agalactiae; vancomycin-resistant Enterococcus faecium

Nausea, vomiting, thrombocytopenia (2.4 percent), myelosuppression

Vancomycin-resistant E. faecium infections; nosocomial pneumonia; complicated skin and skin structure infections; uncomplicated skin and skin structure infections; community-acquired pneumonia

IV, PO (tablets, suspension)

IV = 143.74; tablet = 106.26 (600 mg every 12 hours)

Quinupristin/dalfopristin

Inhibits protein synthesis at elongation step, similar to aminoglycosides, clindamycin (Cleocin), and chloramphenicol (Chloromycetin).

S. aureus (MSSA); S. pyogenes; vancomycin-resistant Enterococcus faecium

Phlebitis, arthralgias/myalgias, hyperbilirubinemia (25 percent)

Vancomycin-resistant E. faecium infections; complicated skin and skin structure infections

IV

IV = 322.28 (500 mg every 8 hours)

Clinical significance

Similar site of inhibition may allow cross-resistance between Q/D, aminoglycosides, clindamycin, and chloramphenicol.

Q/D is not FDA approved for MRSA infections. Although not FDA approved for Enterococcus faecalis, linezolid has in-vitro activity against this pathogen. Q/D is not active against E. faecalis.

Lower infusion-related side effects with linezolid

Broader FDA indications may allow clinicians to feel more comfortable prescribing linezolid.

Allows opportunity for conversion to oral therapy for outpatient treatment with linezolid


MSSA = methicillin-susceptible Staphylococcus aureus; MRSA = methicillin-resistant Staphylococcus aureus; IV = intravenous; PO = by mouth; Q/D = quinupristin/dalfopristin; FDA = U.S. Food and Drug Administration.

*—Estimated cost to the pharmacist based on average wholesale prices in Red book. Montvale, N.J.: Medical Economics Data, 2001. Cost to the patient will be higher, depending on prescription filling fee.

TABLE 5   Comparison of Linezolid (Zyvox) to Quinupristin/Dalfopristin (Synercid)

View Table

TABLE 5

Comparison of Linezolid (Zyvox) to Quinupristin/Dalfopristin (Synercid)

Drug/clinical significance Mechanism of action FDA-approved spectrum of activity Side-effect profile FDA-approved indications Dosage forms Daily cost ($)*

Linezolid

Inhibits protein synthesis at initiation step.

Streptococcus pneumoniae (penicillin sensitive); Staphylococcus aureus (MSSA and MRSA); Streptococcus pyogenes; Streptococcus agalactiae; vancomycin-resistant Enterococcus faecium

Nausea, vomiting, thrombocytopenia (2.4 percent), myelosuppression

Vancomycin-resistant E. faecium infections; nosocomial pneumonia; complicated skin and skin structure infections; uncomplicated skin and skin structure infections; community-acquired pneumonia

IV, PO (tablets, suspension)

IV = 143.74; tablet = 106.26 (600 mg every 12 hours)

Quinupristin/dalfopristin

Inhibits protein synthesis at elongation step, similar to aminoglycosides, clindamycin (Cleocin), and chloramphenicol (Chloromycetin).

S. aureus (MSSA); S. pyogenes; vancomycin-resistant Enterococcus faecium

Phlebitis, arthralgias/myalgias, hyperbilirubinemia (25 percent)

Vancomycin-resistant E. faecium infections; complicated skin and skin structure infections

IV

IV = 322.28 (500 mg every 8 hours)

Clinical significance

Similar site of inhibition may allow cross-resistance between Q/D, aminoglycosides, clindamycin, and chloramphenicol.

Q/D is not FDA approved for MRSA infections. Although not FDA approved for Enterococcus faecalis, linezolid has in-vitro activity against this pathogen. Q/D is not active against E. faecalis.

Lower infusion-related side effects with linezolid

Broader FDA indications may allow clinicians to feel more comfortable prescribing linezolid.

Allows opportunity for conversion to oral therapy for outpatient treatment with linezolid


MSSA = methicillin-susceptible Staphylococcus aureus; MRSA = methicillin-resistant Staphylococcus aureus; IV = intravenous; PO = by mouth; Q/D = quinupristin/dalfopristin; FDA = U.S. Food and Drug Administration.

*—Estimated cost to the pharmacist based on average wholesale prices in Red book. Montvale, N.J.: Medical Economics Data, 2001. Cost to the patient will be higher, depending on prescription filling fee.

Linezolid therapy has been found to cure or improve more than 90 percent of patients treated for skin and soft tissue infections.16 The 400-mg and 600-mg dosages twice daily produced clinical success rates exceeding 89 percent in patients with complicated and uncomplicated skin/soft tissue infections.16 Linezolid also exhibited similar efficacy to oxacillin (Bactocill)/dicloxacillin and vancomycin.16

Comparison to Quinupristin/Dalfopristin

Quinupristin/dalfopristin (Synercid) was recently approved by the FDA for the treatment of patients with vancomycin-resistant Enterococcus faecium, methicillin-susceptible and methicillin-resistant infections. Although no randomized clinical trials have compared these agents, several notable differences exist (Table 5).

Final Comment

The oxazolidinones is a new class of antibiotics that are effective against many resurgent gram-positive organisms. The first of the oxazolidinones, linezolid, is available as an intravenous or oral agent. Its high bioavailability allows initial oral therapy for many infections and a convenient switch from intravenous to oral therapy when indicated. In addition, the every 12 hours dosing schedule improves compliance. Parallel to the increasing resistance among the common pathogens, linezolid is an exciting therapeutic option.

Nevertheless, there is no reason to believe that resistance will not emerge. This will depend on how responsibly and frequently linezolid is prescribed and how quickly bacteria can evolve a new defense. As emphasized earlier, linezolid should be reserved for the treatment of patients with infections caused by multidrug-resistant bacteria that are proved by laboratory testing, and to life-threatening or complicated infections associated with multiple resistances to first-line treatments. Thus far, it has demonstrated activity against all clinically significant, gram-positive bacteria. With its role in multidrug-resistant bacteria, linezolid will play a crucial role in both the community and the nosocomial setting. Physicians should prescribe this agent judiciously so as to minimize antimicrobial resistance.

The Authors

PAUL W. AMENT, Pharm.D., is assistant director, Clinical Pharmacy Services, and family medicine residency faculty member, Latrobe Area Hospital, Latrobe, Pa. Dr. Ament is an instructor in family medicine at Jefferson Medical College of Thomas Jefferson University, Philadelphia. He received his doctor of pharmacy degree at Duquesne University School of Pharmacy, Pittsburgh, and completed a residency in hospital pharmacy at Mercy Hospital, Pittsburgh.

NAMIRAH JAMSHED, M.D., is currently completing a residency in family medicine at Latrobe Area Hospital, Latrobe, Pa. Dr. Jamshed received her medical degree from the Aga Khan University, Pakistan.

JOHN P. HORNE, M.D., is an instructor in family medicine and the medical student coordinator at Latrobe Area Hospital, Latrobe, Pa. Dr. Horne received his medical degree from the University of Pittsburgh School of Medicine and completed a residency in family medicine at Latrobe Area Hospital.

Address correspondence to Paul W. Ament, Pharm.D., Latrobe Area Hospital, 121 W. 2nd Ave., Latrobe, PA 15650.(e-mail: pament@lah.com). Reprints are not available from the authors.

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18. Leach TS, Lobeck FG, Todd WM, Hafkin B. Lack of serotonin syndrome in Phase III patients receiving linezolid and an SSRI. Poster session. Poster #64 from Proceedings of the 38th Annual Infectious Disease Society of America Meeting; September 7–10, 2000, New Orleans, La.

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20. Birmingham MC, Zimmer GS, Flavin SM, Rayner CR, Welch KE, Smith PF, et al. Results of treating bacteremic patients with linezolid in a compassionate use trial for resistant, gram-positive infections. The Clinical Pharmacokinetics Laboratory, Kaleida Health/Millard Fillmore Hospital and SUNY at Buffalo, NY, USA. Retrieved May 2001, from: http://www.icmask.org/icmasko5/abstracts.cgi?number=8.24.

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Richard W. Sloan, M.D., R.Ph., coordinator of this series, is chairman and residency program director of the Department of Family Medicine at York (Pa.) Hospital and clinical associate professor in family and community medicine at the Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pa.


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