Letters to the Editor
Erythrasma and Common Bacterial Skin Infections
Am Fam Physician. 2003 Jan 15;67(2):254.
to the editor: I read with great interest the article entitled, “Common Bacterial Skin Infections,”1 and I would like to make an additional comment concerning cutaneous erythrasma and its causative organism, Corynebacterium minutissimum.2 Erythrasma is a cutaneous disorder of which the lesions may present as patches that are asymptomatic and well defined, or irregular in shape and size and red in color. The lesions may become brownish and appear slightly raised from the surrounding skin with the appearance of central clearing. Interdigital erythrasma is a common bacterial infection of the foot.
In some studies, up to 30 percent of patients with interdigital erythrasma have been found to have a coexisting dermatophyte or Candida albicans infection, usually noted in the third and fourth interspaces.2 Areas of the body that favor C. minutissimum growth are moist, occluded intertriginous areas such as the axillae, inframammary areas, and interspaces of the toes, as well as the intergluteal and crural folds. Factors such as a warm climate, poor hygiene, obesity, hyperhidrosis, advanced age, compromised host status, and diabetes mellitus also play a role in the occurrence of this organism.
The differential diagnosis of erythrasma includes psoriasis, dermatophytosis, candidiasis, and intertrigo. Examination with Wood's light shows a coral-red fluorescence and is the diagnostic procedure of choice; however, microscopic examination and cultures may be required in certain instances when the Wood's light examination is negative, yet the organism is still suspected and a detection and treatment algorithm has been proposed.2
The most effective treatment is erythromycin (250 mg, four times daily for 14 days) with cure rates (both clinical and bacteriologic) as high as 100 percent. In patients with interdigital involvement or hidden reservoirs, some form of local therapy is recommended, such as clindamycin (Cleocin) or Whitfield's ointment applied once daily during the course of oral therapy and continued for two weeks after the physical clearance of these areas. Interestingly, a literature search of the treatment of interdigital erythrasma, antifungal agents that have been proposed for topical treatment, such as tolnaftate (Tinactin), haloprogin (Halotex), clotrimazole (Lotrimin), bifonazole (Canesten), and econazole (Spectazole), yield poor and inconclusive results in the treatment of this condition.2
1. Stulberg DL, Penrod MA, Blatny RA. Common bacterial skin infections. Am Fam Physician. 2002;66:119–24.
2. Holdiness MR. Management of cutaneous erythrasma. Drugs. 2002;62:1131–41.
Send letters to Kenneth W. Lin, MD, MPH, Associate Deputy Editor for AFP Online, e-mail: email@example.com, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680.
Please include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.
Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the American Academy of Family Physicians permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.
Copyright © 2003 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact firstname.lastname@example.org for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions