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Treatment of Hyperlipidemia in Elderly Patients

Am Fam Physician. 2003 May 1;67(9):1996-1998.

Approximately 80 percent of all deaths from coronary heart disease (CHD) occur in persons older than 65 years, and CHD is the leading cause of death in this age group. At least 25 percent of men and 42 percent of women in this age group have serum total cholesterol levels above 240 mg per dL. Nevertheless, the association between elevated cholesterol levels and CHD is not as strong in elderly persons as in younger adults, and the benefits of reducing cholesterol levels have not been clearly demonstrated in older patients. Dalal and Robbins reviewed the evidence of benefit from lipid- lowering therapy in elderly patients.

They reviewed data from four secondary prevention trials that included significant numbers of persons older than 65 years. The Scandinavian Simvastatin Survival Study followed more than 1,000 patients for six years and reported a 33 percent reduction in all- cause mortality, a 42 percent reduction in CHD mortality, and a 33 percent reduction in major coronary events in the treated group. The absolute risk reduction was 6.2 percent, and an estimated 10 CHD-related deaths and 17 major cardiac events were prevented per 1,000 patient-years of treatment. Similar results were reported from the Cholesterol and Recurrent Events trial, which followed 1,283 patients with established CHD who were treated with pravastatin for five years, and from the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) trial, which followed 3,514 patients for six years.

From these studies and the Veterans Affairs study of men with established CHD and continuing risk factors, the authors conclude that in patients older than 65, secondary prevention of CHD with lipid-lowering medications is effective and does not increase mortality or cause significant adverse events. They recommend statins as first-line therapy, with bile acid sequestrants as alternatives unless triglycerides are elevated (see the accompanying table on page 1998). The evidence of benefit from drug therapy is less clear in patients older than 75. In these patients, overall general health and comorbid conditions must be considered.

For primary prevention in older patients, the National Cholesterol Education Program recommends lifestyle changes as first-line therapy because of unknown effectiveness and concerns about side effects of lipid-lowering medications. Two large studies of primary prevention that included significant numbers of elderly patients concluded that primary prevention benefitted older patients. The West of Scotland Coronary Prevention Study of pravastatin included 3,370 men older than 55. After five years, treatment was associated with a 22 percent reduction in total mortality and a 31 percent reduction in coronary events. The rate of first major coronary events also was decreased (by 37 percent after 5.2 years of follow-up) in the Air Force/Texas Coronary Atherosclerosis Prevention Study that examined lovastatin therapy for primary prevention in 1,416 patients age 65 to 73. In these and smaller studies, medication has effectively provided primary prevention for CHD without causing significant adverse events.

Approach to Primary CHD Prevention in Elderly Patients

LDL cholesterol level Number of risk factors Goal Therapeutic considerations

Intermediate risk

130 to 159 mg per dL (3.37 to 4.12 mmol per L)

< 2

<130 mg per dL

Lifestyle changes,* avoid drug therapy

≥2

<130 mg per dL

Lifestyle changes, consider low-dose statin if diabetes mellitus or PVD present

Moderately high risk

160 to 189 mg per dL (4.14 to 4.90 mmol per L)

< 2

< 160 mg per dL

Intensify lifestyle changes,† consider low-dose statin if needed

≥2

< 130 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant

High risk

≥190 mg per dL (4.92 mmol per L)

< 2

<1 60 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant, or fibrate or niacin if triglyceride level is also elevated

≥2

< 130 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant, or fibrate or niacin if triglyceride level is also elevated


CHD = coronary heart disease; LDL = low-density lipoprotein; PVD = peripheral vascular disease.

*—Lifestyle changes include American Heart Association (AHA) step 1 diet, weight control, regular exercise, and smoking cessation.

†—Intensified lifestyle changes include AHA step 2 diet, medically supervised weight reduction, exercise program, and smoking cessation.

Adapted with permission from Grundy SM, Cleeman JI, Rifkind BM, Kuller LH. Cholesterol lowering in the elderly population. Coordinating Committee of the National Cholesterol Education Program. Arch Intern Med 1999;159:1677.

Approach to Primary CHD Prevention in Elderly Patients

View Table

Approach to Primary CHD Prevention in Elderly Patients

LDL cholesterol level Number of risk factors Goal Therapeutic considerations

Intermediate risk

130 to 159 mg per dL (3.37 to 4.12 mmol per L)

< 2

<130 mg per dL

Lifestyle changes,* avoid drug therapy

≥2

<130 mg per dL

Lifestyle changes, consider low-dose statin if diabetes mellitus or PVD present

Moderately high risk

160 to 189 mg per dL (4.14 to 4.90 mmol per L)

< 2

< 160 mg per dL

Intensify lifestyle changes,† consider low-dose statin if needed

≥2

< 130 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant

High risk

≥190 mg per dL (4.92 mmol per L)

< 2

<1 60 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant, or fibrate or niacin if triglyceride level is also elevated

≥2

< 130 mg per dL

Intensify lifestyle changes, consider statin, bile acid sequestrant, or fibrate or niacin if triglyceride level is also elevated


CHD = coronary heart disease; LDL = low-density lipoprotein; PVD = peripheral vascular disease.

*—Lifestyle changes include American Heart Association (AHA) step 1 diet, weight control, regular exercise, and smoking cessation.

†—Intensified lifestyle changes include AHA step 2 diet, medically supervised weight reduction, exercise program, and smoking cessation.

Adapted with permission from Grundy SM, Cleeman JI, Rifkind BM, Kuller LH. Cholesterol lowering in the elderly population. Coordinating Committee of the National Cholesterol Education Program. Arch Intern Med 1999;159:1677.

The authors conclude that lipid-lowering therapy should be considered for patients age 65 to 75 years who have a history of CHD or a moderate to high risk for CHD. In patients older than 75, decisions should be made for each individual based on life expectancy, comorbidities, and other concerns.

Dalal D, Robbins JA. Management of hyperlipidemia in the elderly population: an evidence-based approach. South Med J. November 2002;95:1255–61.

editor's note: Although these results are encouraging, they do not mean that we should avoid taking a comprehensive approach to preventing coronary (and other) diseases in older patients. We need to address smoking, exercise, nutrition, and stress reduction in these patients, as well as the “medical” tasks of screening and prescribing. Many elderly patients have enormous vitality and live very active lives, regardless of impressive medical histories. For these patients, the longer I can be a “coach,” the better. The unsolvable medical problems will intervene soon enough.—a.d.w.

 

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