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American Family Physician
Patient Information

Please note: This information was as current as we could make it on the date given above. But medical information is always changing, and some information given here may be out of date. For regularly updated information on a variety of health topics, please visit familydoctor.org, the AAFP patient education Web site.

An article on this topic is available in this issue of AFP.

Warning Signs of Primary Immunodeficiency

What is a primary immunodeficiency?

A primary immunodeficiency is a genetic problem with the immune system. The immune system protects the body against infection--and fights infection when it happens.

People who have a primary immunodeficiency disorder get infections easily. The infections tend to come back often and are hard to cure.

There are more than 80 different kinds of primary immunodeficiency disorders. Some are common. Others are rare.

What are some warning signs of a primary immunodeficiency?

As part of a national educational program, The Jeffrey Modell Foundation (http://www. jmfworld.com) has developed a list of warning signs for primary immunodeficiency. Talk to your doctor if you or your child has more than one of these warning signs:

  • Eight or more ear infections in one year
  • Two or more serious sinus infections in one year.
  • An infection that does not get better even after two or more months of antibiotic therapy
  • Poor weight gain or lack of normal growth in your baby
  • Deep skin or organ abscesses that keep coming back
  • After the age of one year, hard-to cure thrush (a fungal infection) in the mouth or elsewhere in the skin
  • Need for intravenous antibiotic treatment to clear infections
  • Two or more serious infections deep below the skin
  • A family history of primary immunodeficiency

More Information About Primary Immunodeficiency

For more information, you can contact these groups:

The Jeffrey Modell Foundation
747 Third Avenue
New York, NY 10017
Telephone: 1-212-819-0200
Fax: 1-212-764-4180
Web site: http://www.info4pi.org
E-mail: info@imfworld.org

Immune Deficiency Foundation
40 West Chesapeake Ave.
Suite 308
Towson, MD 21204
Telephone: 1-800-296-4433
Web site: http://www.primaryimmune.org
E-mail: idf@primaryimmune.org


This handout provides a general overview on this topic and may not apply to everyone. To find out if this handout applies to you and to get more information on this subject, talk to your family doctor.

Visit familydoctor.org for information on this and many other health-related topics.

Copyright © 2003 by the American Academy of Family Physicians.
Permission is granted to print and photocopy this material for nonprofit educational uses. Written permission is required for all other uses, including electronic uses.



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