Letters to the Editor

Bupropion Should Be Included in Article on Antidepressants

Am Fam Physician. 2004 Jun 1;69(11):2528.

to the editor: Although the article1 by Drs. Ables and Baughman in the February 1, 2003, issue of American Family Physician seemed to be a comprehensive review of antidepressant agents, it did not mention bupropion (Wellbutrin). This agent is novel because it is a norepinephrine and dopamine reuptake inhibitor. It has the same efficacy as any selective serotonin reuptake inhibitor (SSRI) for the treatment of depression and has characteristically different side effects. It does not have the sexual dysfunction and gastrointestinal side effects associated with SSRIs. However, it can cause sleeplessness, agitation, and vivid dreams.2 Also, it is not associated with weight gain, while patients receiving SSRIs tend to gain weight. Bupropion (such as Zyban) also is indicated for smoking cessation.3 It is particularly useful for patients who are depressed and attempting to quit smoking.

REFERENCES

1. Ables AZ, Baughman OL 3d. Antidepressants: update on new agents and indications. Am Fam Physician. 2003;67:547–54.

2. Bupropion (Wellbutrin XL). Package insert. Philadelphia: GlaxoSmith-Kline 2003. Accessed March 11, 2004 at: http://us.gsk.com/products/assets/us_wellbutrinxl.pdf.

3. Bupropion (Zyban). Package insert. Philadelphia: GlaxoSmith-Kline 2003. Accessed March 11, 2004 at: http://us.gsk.com/products/assets/us_zyban.pdf.

in reply: I would like to thank Dr. Wax for his comments. Our article1 was not meant to be a comprehensive review. We were asked to provide an update on new agents and/or indications. Bupropion has been on the market since 1985 and, hopefully, physicians are aware of its advantages in the treatment of depression.

REFERENCE

1. Ables AZ, Baughman OL 3d. Antidepressants: update on new agents and indications. Am Fam Physician. 2003;67:547–54.

Send letters to Kenneth W. Lin, MD, MPH, Associate Deputy Editor for AFP Online, e-mail: afplet@aafp.org, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680.

Please include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.

Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the American Academy of Family Physicians permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.


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