Letters to the Editor
Hyperbaric Oxygen to Treat Malignant External Otitis
Am Fam Physician. 2004 Nov 15;70(10):1860.
to the editor: We read with interest the article, “Necrotizing (Malignant) External Otitis,”1 by Drs. Handzel and Halperin in the July 15, 2003, issue of American Family Physician, and would like to present our experience in the treatment of malignant external otitis.
Between 1998 and 2003, nine patients (three women and six men) with a mean age of 64.8 years were treated for malignant external otitis at our department of otolaryngology. All treated patients had diseases that could affect their immune system, such as diabetes (seven patients), leukemia (one patient), and bronchial asthma (one patient). Five of the nine patients had palsy of at least one of the cranial nerves. Standard therapy included local treatment of the auditory canal, long-term systemic antibiotic therapy, radical mastoidectomy (two patients), and petrosectomy (one patient). Eight of the nine patients underwent hyperbaric oxygenation. One patient did not qualify for this treatment because of pulmonary contraindications. All eight patients received 100 percent oxygen in a multiplace chamber under 2.5 standard atmospheres of pressure (ATA) for 60 minutes (with two five-minute breaks) once daily, five days a week. The pressure inside the hyperbaric chamber was achieved by compressed air. The total number of sessions depended on clinical status. The mean number of hyperbaric oxygen sessions was 22.1 (range: 16 to 25 sessions). We received good results in all eight patients who were treated with hyperbaric oxygen. Headache and discharge from the ear ceased, bacteriologic examinations of the ear swabs were negative, and changes in bone scintigraphy decreased; however, cranial nerve palsy was still observed. Follow-up ranged from nine months to four years. Malignant external otitis is not a primary indication for hyperbaric oxygen according to the Undersea and Hyperbaric Medicine Society (UHMS) and the European Committee for Hyperbaric Medicine (ECHM). However, we found hyperbaric oxygen very helpful in the adjunctive treatment of malignant external otitis because it proved to be effective in normalizing oxygen tension, which is necessary for the following: (1) destruction of bacteria by polymorphonuclear leucocytes; (2) stimulation of neo-vascular formation; and (3) stimulation of osteoclastic and osteoblastic activity. Our clinical observations confirm the experience of other authors.2–6 The rarity of this disease makes it difficult to organize prospective, randomized, double-blind clinical trials that demonstrate the real benefits of hyperbaric oxygen in treating malignant external otitis. For this reason, any clinical experience and observations of this disease are of great value.
1. Handzel O, Halperin D. Necrotizing (malignant) external otitis. Am Fam Physician. 2003;68:309–12.
2. Davis JC, Gates GA, Lerner C, Davis MG Jr, Mader JT, Dinesman A. Adjuvant hyperbaric oxygen in malignant external otitis. Arch Otolaryngol Head Neck Surg. 1992;118:89–93.
3. Kuczkowski J, Ozdzinski W, Kowalska B, Mikaszewski B. Necrotizing malignant otitis — diagnostic and therapeutic problems [in Polish]. In: Proceedings of the International Symposium “Rehabilitation in otology.” Poznan, Poland;1999:99–102.
4. Pilgramm M, Frey G, Schumann K. Hyperbaric oxygenation: a sensible adjunctive therapy in malignant external otitis [in German]. Laryngol Rhinol Otol [Stuttg]. 1986;65:26–8.
5. Shupak A, Greenberg E, Hardoff R, Gordon C, Melamed Y, Meyer WS. Hyperbaric oxygenation for necrotizing (malignant) otitis externa. Arch Otolaryngol Head Neck Surg. 1989;115:1470–5.
6. Tos M. Malignant otitis externa In: Tos M, ed. Manual of middle ear surgery. Vol. 3. New York: Georg Thieme Verlag, 1997:241–6.
editor’s note: This letter was sent to the authors of “Necrotizing (Malignant) External Otitis,” who declined to reply.
Send letters to Kenneth W. Lin, MD, MPH, Associate Deputy Editor for AFP Online, e-mail: firstname.lastname@example.org, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680.
Please include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.
Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the American Academy of Family Physicians permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.
Copyright © 2004 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact email@example.com for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions