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Menorrhagia and Screening for von Willebrand Disease



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Am Fam Physician. 2005 May 15;71(10):1994-1995.

Menorrhagia is a significant health problem for women of reproductive age and was responsible for nearly 98,000 hospital admissions in the year 2000. Among the various causes of menorrhagia, coagulation disorders are particularly serious because they can increase the risks of surgical treatment. The most common coagulation disorder, von Willebrand disease, has an estimated prevalence of 5 to 20 percent in women with menorrhagia, compared with less than 1 percent in other women. In 2001, the American College of Obstetricians and Gynecologists recommended screening for von Willebrand disease in adolescents with menorrhagia, women in whom a cause for menorrhagia cannot be established, and women undergoing hysterectomy for menorrhagia. However, the evidence behind this recommendation is controversial. James and colleagues conducted a systematic review of relevant studies to determine the value of screening for von Willebrand disease in women with menorrhagia.

An initial search of electronic databases, abstracts of conferences, and bibliographies, in addition to consultation with experts, identified more than 150 items. After independent review, 107 articles, published from 1990 to 2003, were selected for inclusion in the study. Five articles concerned the prevalence of von Willebrand disease in women with menorrhagia, differing in the populations studied and definitions of the disease and condition. These studies involved between 19 and 150 women and provided prevalence estimates of between 5.3 and 20 percent. The confidence intervals in each study were high (e.g., 7.9 to 18.8 percent and 4.0 to 14.2 percent for the two largest).

Studies on the impact of von Willebrand disease and menorrhagia on quality of life also differed considerably in the definitions and measures used. These studies indicate that von Willebrand disease with menorrhagia has a significant negative impact on quality of life, but no data were identified to suggest that this impact is worse than that of menorrhagia alone. Only three studies, with a total of 29 patients, addressed any increased risk of surgery in women with von Willebrand disease, and data were limited further by the uncertainty of case identification.

The authors also reviewed articles on screening tests for von Willebrand disease. Several tests are available and estimates of the sensitivity and specificity of each one vary. Comparisons between the tests could not be made from the available data; thus the most effective test was not determined.

The authors conclude that although von Willebrand disease may be more prevalent in women with menorrhagia than in the general population, it is difficult to identify the proportion of menorrhagia cases attributable to this disease. In addition, there are too few data to confirm the degree of enhanced morbidity or surgical risk in women who have menorrhagia with von Willebrand disease. Routine screening for von Willebrand disease in women with menorrhagia therefore is not supported sufficiently by current evidence. Further data are needed.

James A, et al. Testing for von Willebrand disease in women with menorrhagia: a systematic review. Obstet Gynecol. August 2004;104:381–8.



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