ANNE-MARIE LOZEAU, M.D., M.S., and BETH POTTER, M.D.

This high-risk condition, which is the leading cause of pregnancy-related death in the first trimester, can be treated by expectant management, medical management with methotrexate, or surgery.

Patient information: "Ectopic Pregnancy: What You Should Know," p. 1719

SUSAN SNYDER, M.D., and BERNADETTE PENDERGRAPH, M.D.

Once chronic kidney disease is detected, the underlying causes should be identified and treated to delay or prevent progression to kidney failure.

Patient information: "Chronic Kidney Disease," p. 1733

EDDIE NEEDHAM, M.D.

The cause should be identified as prerenal, intrarenal, or postrenal, with management strategies including correction of fluid and electrolyte levels, avoidance of nephrotoxins, and kidney replacement therapy.

Todd A. Forman, M.D., M.S.Ed., Scott k. forman, m.d., and nicholas e. rose, m.d.

A variety of diagnostic tests and a basic understanding of common causes of wrist pain can assist in evaluating patients with wrist problems.

MARJORIE P. GOLDEN, M.D., and HOLENARASIPUR R. VIKRAM, M.D.

Diagnosis can be elusive and necessitates a high index of suspicion, but response to empiric therapy usually is favorable.

STEVEN H. WILLIAMS, PH.D.

New evidence supports the pharmacologic treatment of alcohol dependence, with serotonergic and anticonvulsant agents potentially playing a larger role.