Cochrane Briefs

Am Fam Physician. 2006 Oct 1;74(7):1125-1126.

Expectant Management vs. Surgical Treatment for Miscarriage

Clinical Question

What is the safety and effectiveness of expectant management versus surgical treatment for first-trimester miscarriage?

Evidence-Based Answer

Expectant management and surgical treatment are safe and effective for first-trimester miscarriage. Among patients who choose expectant management, there is a lower rate of pelvic infection but higher rates of mild bleeding, need for unplanned surgical treatment, and incomplete miscarriage.

Practice Pointers

When a nonviable first-trimester pregnancy is diagnosed, women have the option of waiting for the uterine contents to pass, choosing medical management with medications such as misoprostol (Cytotec), or undergoing dilation and curettage. Without intervention, more than 65 percent of missed abortions and 80 percent of incomplete and first-trimester abortions pass naturally within two to six weeks.1 Misoprostol 600 to 1,200 mcg vaginally on day 1, with a repeat dose if indicated on day 3, has been proven safe and effective. Success rates approach 95 percent, and women find their experience satisfactory.2,3 Surgical management includes vacuum extraction, suction curettage, or sharp curettage with or without dilation. Surgical management is the definitive treatment when other methods fail.

Nanda and colleagues reviewed the literature for trials comparing expectant management with surgical treatment for miscarriage. They found five trials with a total of 689 participants.

Expectant management had higher rates of incomplete miscarriage, need for unplanned surgical treatment, and bleeding, but a lower rate of pelvic infection (relative risk 0.29; 95% confidence interval, 0.09 to 0.87). Rates of infection ranged from 0 to 10 percent. Overall, there were two women in expectant management groups who required blood transfusion. However, rates of hemorrhage greater than 500 mL and bleeding requiring transfusion were not statistically significant between expectant management and surgical treatment groups. Two to 20 percent of women in the expectant management groups needed surgery. Unplanned surgical management usually was attributed to unacceptable pain, bleeding, or patient request. There were no differences in serious adverse events between the expectant management and surgical treatment groups.

Rates of complete abortion varied by study. In one study, the rate of complete abortion in the expectant management group was 81 percent at less than two weeks and 93 percent at seven weeks. Surgical treatment had a complete abortion rate of 97 percent at less than two weeks; no patients required second procedures. There is no clear indication for routine surgical management; therefore, patient preference should be respected.

Source:

Nanda K, et al. Expectant care versus surgical treatment for miscarriage. Cochrane Database Syst Rev. 2006;(2):CD003518.

REFERENCES

1. Butler C, Kelsberg G, St Anna L, Crawford P. Clinical inquiries. How long is expectant management safe in first-trimester miscarriage?. J Fam Pract. 2005;54:889–90.

2. Nguyen TN, Blum J, Durocher J, Quan TT, Winikoff B. A randomized controlled study comparing 600 versus 1,200 microg oral misoprostol for medical management of incomplete abortion. Contraception. 2005;72:438–42.

3. Creinin MD, Huang X, Westhoff C, Barnhart K, Gilles JM, Zhang J, for the National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial. Factors related to successful misoprostol treatment for early pregnancy failure. Obstet Gynecol. 2006;107:901–7.


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