ANNE L. MOUNSEY, M.D., ALEX WILGUS, M.D., and DAVID C. SLAWSON, M.D.

Because the signs and symptoms of endometriosis are nonspecific, the preferred diagnostic method is surgical visual inspection of pelvic organs with histologic confirmation. Oral contraceptive pills and medroxyprogesterone acetate are first-line treatments. There is limited evidence that surgical ablation of endometriotic deposits may decrease pain and increase fertility rates in women with endometriosis.

Patient information: "Endometriosis: What You Should Know," p. 601

AMY L. STUMP, PHARM.D., TERRI MAYO, PHARM.D., and ALAN BLUM, M.D.

Grapefruit can affect the metabolism of some medications including statins, antiarrhythmic agents, immunosuppressants, and calcium channel blockers. Family physicians should be aware of which medications may interact with grapefruit and of alternatives for these medications.

Patient information: Medicine Interactions with Grapefruit: What You Should Know," p. 611

SPENCER A. MORRIS, PHARM.D., B.C.P.S., H. FLOYD HATCHER, M.D., and DEEPA K. REDDY, M.D.

Digoxin has been considered a fundamental therapy for heart failure. However, data bring into question the safety of this therapy, including the optimal serum digoxin concentration and the use of this therapy in women.

LINDA S. NIELD, M.D., PRASHANT MAHAJAN, M.D., M.P.H., APARNA JOSHI, M.D., and DEEPAK KAMAT, M.D., PH.D.

Early diagnosis and treatment of rickets can normalize biochemical abnormalities and prevent complications that may require surgical intervention.

Patient information: "Rickets: What It Is and How It's Treated," p. 629

Editorial: "Rickets: Emerging from Obscurity," p. 561