Update on Helicobacter pylori Treatment

Am Fam Physician. 2007 Feb 1;75(3):351-358.

One half of the world's population has Helicobacter pylori infection, with an estimated prevalence of 30 percent in North America. Although it is unclear whether eradication of H. pylori improves symptoms in patients with nonulcer dyspepsia, there is strong evidence that eradication of this bacteria improves healing and reduces the risk of recurrence or rebleeding in patients with duodenal or gastric ulcer. A “test-and-treat” strategy is recommended for most patients with undifferentiated dyspepsia. With this approach, patients undergo a noninvasive test for H. pylori infection and, if positive, are treated with eradication therapy. This strategy reduces the need for antisecretory medications as well as the number of endoscopies. The urea breath test or stool antigen test is recommended. Until recently, the recommended duration of therapy for H. pylori eradication was 10 to 14 days. Shorter courses of treatment (i.e., one to five days) have demonstrated eradication rates of 89 to 95 percent with the potential for greater patient compliance. A one-day treatment course consists of bismuth subsalicylate, amoxicillin, and metronidazole, all given four times with a one-time dose of lansoprazole. In children with documented H. pylori infection, however, all regimens should continue to be prescribed for seven to 14 days until short-course treatment is studied and its effectiveness has been established in this population.

The discovery of Helicobacter pylori as a causative agent of peptic ulcer disease has revolutionized the medical field's understanding of the treatment of this condition.1 Many patients still attribute symptoms of dyspepsia to an ulcer, and believe that ulcers are caused by diet, stress, and lifestyle factors; however, it is now clear that eradication of H. pylori is central to the management of this illness. Primary care physicians are typically faced with patients who present with undifferentiated dyspepsia rather than documented peptic ulcer disease. This article briefly describes the evaluation of the patient with dyspepsia in light of our knowledge of the epidemiology of H. pylori infection, and reports new information about special populations and eradication using short-duration treatment regimens.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References Comment

A “test-and-treat” strategy is recommended in patients with symptoms of dyspepsia.

A

915, 27

Test-and-treat strategy reduces endoscopies and use of antisecretory medications.

Helicobacter pylori eradication therapy is recommended to prevent recurrence and rebleeding in patients with peptic ulcer.

A

24

It is unnecessary to continue antisecretory maintenance therapy in patients after H. pylori eradication.

Short-course drug therapy is an option for H. pylori eradication in adult patients.

C

38, 39

Eradication rates using short-course therapy are similar to those of traditional treatment with the potential for greater compliance.

The urea breath test is the most reliable noninvasive diagnostic test in children with suspected H. pylori infection.

C

20, 21

Urea breath test is more reliable in children older than six years; monoclonal antibody-based stool antigen is an alternative.


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, see page 295 or http://www.aafp.org/afpsort.xml.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

View Table

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References Comment

A “test-and-treat” strategy is recommended in patients with symptoms of dyspepsia.

A

915, 27

Test-and-treat strategy reduces endoscopies and use of antisecretory medications.

Helicobacter pylori eradication therapy is recommended to prevent recurrence and rebleeding in patients with peptic ulcer.

A

24

It is unnecessary to continue antisecretory maintenance therapy in patients after H. pylori eradication.

Short-course drug therapy is an option for H. pylori eradication in adult patients.

C

38, 39

Eradication rates using short-course therapy are similar to those of traditional treatment with the potential for greater compliance.

The urea breath test is the most reliable noninvasive diagnostic test in children with suspected H. pylori infection.

C

20, 21

Urea breath test is more reliable in children older than six years; monoclonal antibody-based stool antigen is an alternative.


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, see page 295 or http://www.aafp.org/afpsort.xml.

Definition and Epidemiology

Dyspepsia is classified as ulcer-like, with symptoms of pain centered in the upper abdomen; dysmotility-like, with symptoms of upper abdominal fullness, early satiety, bloating, or nausea; or unspecified, with symptoms not fitting either of these classifications.2 Even though symptoms of gastroesophageal reflux disease (GERD) and dyspepsia overlap considerably, they usually are viewed as distinct entities.2 Approximately 30 percent of patients with dyspepsia in North America are infected with H. pylori3,4 compared with a prevalence of 80 to 90 percent in the developing world.5 The annual incidence of new H. pylori infections in industrialized countries is approximately 0.5 per 100 persons of the susceptible population compared with three or more per 100 persons in developing countries.6,7

Risk factors for acquiring H. pylori infection include residence in a developing country, poor socioeconomic conditions, family overcrowding, and possibly an ethnic or genetic predisposition.6 In North America, the prevalence of H. pylori among Asian Americans, African Americans, and Hispanics is similar to that among persons in developing countries.8

Initial Evaluation of the Patient with Dyspepsia

In the primary care office, the underlying pathology in patients with dyspepsia often is unknown. Rather than recommending endoscopy for all patients, most national guidelines suggest a “test-and-treat” strategy.911 With this approach, patients who have symptoms of dyspepsia should be tested for H. pylori using a noninvasive method if they are younger than 45 to 55 years (depending on the guideline) and do not have “red flags” for malignancy or complicated ulcer (e.g., dysphagia, early satiety, protracted vomiting, anorexia, loss of more than 10 percent of body weight, melena, rectal bleeding, abdominal mass, previous peptic ulcer disease, jaundice, family history of gastric cancer). If infected, patients are treated with H. pylori eradication therapy.

Several recent economic analyses show that the test-and-treat strategy improves symptoms and is cost-effective compared with other strategies.1214 A long-term follow-up study comparing a test-and-treat strategy versus prompt endoscopy in patients with dyspepsia showed that the former reduced the number of endoscopies performed as well as the number of antisecretory medications administered.15

Patients can be tested for the presence of H. pylori via invasive or noninvasive methods (Table 11622). Although serology for immunoglobulin G often is chosen in the outpatient setting because of its convenience, it is less accurate than either the stool antigen or urea breath test. Indeed, the American Gastroenterological Association recommends one of the latter for optimal testing.11 In addition, the urea breath test and stool antigen test can be used to confirm eradication, whereas serology remains positive for months after eradication.18

TABLE 1

Diagnostic Tests forHelicobacter pylori

Test Sensitivity (%) Specificity (%) Usefulness

Invasive

Endoscopy with biopsy

Diagnostic strategy of choice in children with persistent or severe upper abdominal symptoms

Histology

> 95

100

Sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds

Urease activity

93 to 97

> 95

Sensitivity reduced by PPIs, antibiotics, bismuth-containing compounds, and active bleeding

Culture

70 to 80

100

Technically demanding

Noninvasive

Serology for immunoglobulin G

85

79

Sensitivity and specificity vary widely; positive result may persist for months after eradication

Reliability in children not adequately validated; not recommended

Urea breath test

95 to 100

91 to 98

Requires separate appointments; sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds; reliable test for cure

Best available noninvasive test in children but higher false-positive rates in infants and children younger than six years compared with school-age children and adolescents

H. pylori stool antigen

91 to 98

94 to 99

Test for cure seven days after therapy is accurate; sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds

Easy to perform independent of age; possible alternative to urea breath test; monoclonal antibody-based test most reliable


PPI = proton pump inhibitor.

Information from references 16 through 22.

TABLE 1   Diagnostic Tests forHelicobacter pylori

View Table

TABLE 1

Diagnostic Tests forHelicobacter pylori

Test Sensitivity (%) Specificity (%) Usefulness

Invasive

Endoscopy with biopsy

Diagnostic strategy of choice in children with persistent or severe upper abdominal symptoms

Histology

> 95

100

Sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds

Urease activity

93 to 97

> 95

Sensitivity reduced by PPIs, antibiotics, bismuth-containing compounds, and active bleeding

Culture

70 to 80

100

Technically demanding

Noninvasive

Serology for immunoglobulin G

85

79

Sensitivity and specificity vary widely; positive result may persist for months after eradication

Reliability in children not adequately validated; not recommended

Urea breath test

95 to 100

91 to 98

Requires separate appointments; sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds; reliable test for cure

Best available noninvasive test in children but higher false-positive rates in infants and children younger than six years compared with school-age children and adolescents

H. pylori stool antigen

91 to 98

94 to 99

Test for cure seven days after therapy is accurate; sensitivity reduced by PPIs, antibiotics, and bismuth-containing compounds

Easy to perform independent of age; possible alternative to urea breath test; monoclonal antibody-based test most reliable


PPI = proton pump inhibitor.

Information from references 16 through 22.

Potential Benefits of Treatment

PEPTIC ULCER DISEASE

In a meta-analysis of 34 studies of patients with duodenal ulcers, H. pylori eradication plus antisecretory therapy was superior to an antisecretory drug alone for healing of the ulcer (number needed to treat [NNT] = 14). One-time H. pylori eradication was just as effective as long-term antisecretory therapy in preventing duodenal ulcer recurrence and was much more effective than no treatment.23

In a meta-analysis of 13 studies of patients with gastric ulcers, there was no statistically significant difference between H. pylori eradication therapy plus antisecretory drugs and antisecretory drugs alone for healing.23 However, gastric ulcer recurrence was significantly less likely following H. pylori eradication when compared with no treatment in nine of the studies (NNT = 4). Four trials reported on symptom resolution at four to six weeks, but the diversity of the study designs made it difficult to draw any conclusions about the superiority of eradication therapy versus antisecretory therapy alone.

Eradication therapy has been reviewed and compared with antisecretory therapy specifically for the prevention of recurrent bleeding from peptic ulcer.24 In patients taking long-term antisecretory drugs after the initial treatment of an ulcer, rebleeding was less common in those who also received H. pylori eradication therapy (1.6 percent versus 5.6 percent, NNT = 25). Thus, H. pylori eradication therapy is recommended to prevent rebleeding in patients with peptic ulcer.

In summary, H. pylori eradication significantly reduces the risk of ulcer recurrence and rebleeding and is less expensive than chronic antisecretory therapy. Continuing antisecretory maintenance therapy for more than two weeks following antibiotic treatment is unnecessary after H. pylori eradication unless patients have concomitant GERD.24 A 2005 evidence-based guideline from the University of Michigan provides a useful algorithm and is consistent with these recommendations (http://cme.med.umich.edu/pdf/guideline/PUD05.pdf).25

NONULCER DYSPEPSIA

At best, H. pylori eradication provides a small and highly variable symptomatic benefit in patients with nonulcer dyspepsia. Although a meta-analysis of 10 studies failed to demonstrate an improvement in symptoms with eradication therapy,26 an updated systematic review of 17 trials revealed a small but statistically significant benefit (NNT = 18).27 The American College of Gastroenterology suggests an empiric trial of acid suppression with a proton pump inhibitor for four to eight weeks as an option for initial treatment of dyspepsia in areas with a low prevalence of H. pylori infection.28

GERD

Testing and treating for H. pylori in patients with GERD has not been shown to improve symptoms.29 In guidelines published in November 2005, the American College of Gastroenterology does not mention testing or treating for H. pylori in the diagnosis and treatment of GERD.30

GASTRIC CANCER PREVENTION

H. pylori has been identified as a group 1 carcinogen by the World Health Organization and is associated with the development of gastric cancer. The risk of developing gastric cancer is increased by three to six times in infected persons.31,32 A meta-analysis of 51 studies revealed a decrease in mucosal inflammation and possible improvement in gastric mucosal atrophy when H. pylori is eradicated.32 In a Japanese study with a mean follow-up of 3.4 years, investigators found that patients with documented gastric ulcer had a decreased likelihood of developing gastric cancer after eradication therapy.33 The results of a small randomized controlled trial involving healthy patients suggest that those treated for H. pylori infection had a lower incidence of preneoplastic findings on endoscopy after one year.34 However, preliminary results from large trials with follow-up extending to seven years demonstrate no difference in the rates of gastric cancer among patients who underwent H. pylori eradication therapy.35,36

In the absence of guidelines or good-quality clinical trials, eradication of H. pylori purely to prevent gastric cancer in otherwise asymptomatic patients is not recommended.

Selection of Therapy to Eradicate H. pylori

When selecting a therapy to eradicate H. pylori, duration of treatment and adverse effects should be considered.

DURATION OF THERAPY

Until recently, the recommended duration of therapy for H. pylori eradication was 10 to 14 days. The most widely recommended regimens are summarized in Table 2.37 Studies evaluating one-, five-, and seven-day regimens to eradicateH. pylori are summarized in Table 3.38,39 Although not proven, potential benefits of shorter regimens include better compliance, fewer adverse drug effects, and reduced cost to the patient.

TABLE 2

Selected long-duration regimens for Helicobacter pylori Eradication

Treatment regimen Duration Eradication rate (%) Cost (generic) per day*

Omeprazole (Prilosec), 20 mg twice daily, plus amoxicillin, 1 g twice daily, plus clarithromycin (Biaxin), 500 mg twice daily

14 days

80 to 86

Omeprazole: $9 (8)

Amoxicillin: $2 (2 to 3)

Clarithromycin: $10 (9)

Lansoprazole (Prevacid), 30 mg twice daily, plus amoxicillin, 1 g twice daily, plus clarithromycin, 500 mg twice daily

10 to 14 days

86

Lansoprazole: $10

Amoxicillin: $2 (2 to 3)

Clarithromycin: $10 (9)

Bismuth subsalicylate (Pepto-Bismol), 525 mg four times daily, plus metronidazole (Flagyl), 250 mg four times daily, plus tetracycline, 500 mg four times daily, plus histamine H2 blocker

14 days (H2 blocker alone for an additional 14 days taken once or twice daily)

80

Bismuth subsalicylate: $1

Metronidazole: $10 (2)

Tetracycline: $2 (1)


*—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) in Red Book. Montvale, N.J.: Medical Economics Data, 2006. Cost to the patient will be higher, depending on prescription filling fee.

Adapted with permission from Meurer LN, Bower DJ. Management of Helicobacter pylori infection. Am Fam Physician 2002;65:1333.

TABLE 2   Selected long-duration regimens for Helicobacter pylori Eradication

View Table

TABLE 2

Selected long-duration regimens for Helicobacter pylori Eradication

Treatment regimen Duration Eradication rate (%) Cost (generic) per day*

Omeprazole (Prilosec), 20 mg twice daily, plus amoxicillin, 1 g twice daily, plus clarithromycin (Biaxin), 500 mg twice daily

14 days

80 to 86

Omeprazole: $9 (8)

Amoxicillin: $2 (2 to 3)

Clarithromycin: $10 (9)

Lansoprazole (Prevacid), 30 mg twice daily, plus amoxicillin, 1 g twice daily, plus clarithromycin, 500 mg twice daily

10 to 14 days

86

Lansoprazole: $10

Amoxicillin: $2 (2 to 3)

Clarithromycin: $10 (9)

Bismuth subsalicylate (Pepto-Bismol), 525 mg four times daily, plus metronidazole (Flagyl), 250 mg four times daily, plus tetracycline, 500 mg four times daily, plus histamine H2 blocker

14 days (H2 blocker alone for an additional 14 days taken once or twice daily)

80

Bismuth subsalicylate: $1

Metronidazole: $10 (2)

Tetracycline: $2 (1)


*—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) in Red Book. Montvale, N.J.: Medical Economics Data, 2006. Cost to the patient will be higher, depending on prescription filling fee.

Adapted with permission from Meurer LN, Bower DJ. Management of Helicobacter pylori infection. Am Fam Physician 2002;65:1333.

TABLE 3

Short-Course Therapy for Eradication of Helicobacter pylori

Treatment regimen Duration (days) Number of patients studied Population studied Eradication rate (%) Cost (generic) per day*

Bismuth subsalicylate (Pepto-Bismol), 524 mg four times a day, plus amoxicillin, 2 g four times a day, plus metronidazole (Flagyl), 500 mg four times a day, plus lansoprazole (Prevacid), 60 mg once38

1

80

H. pylori–positive patients with dyspepsia

95

Bismuth subsalicylate: $1

Amoxicillin: $9 (8 to 12)

Metronidazole: $18 (2 to 7)

Lansoprazole: $20

Clarithromycin (Biaxin), 500 mg twice daily, plus amoxicillin, 1 g twice daily, plus lansoprazole, 30 mg twice daily38

7

80

H. pylori–positive patients with dyspepsia

90

Clarithromycin: $10 (9)

Amoxicillin: $2 (2 to 3)

Amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus lansoprazole, 30 mg twice daily39

5

83

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

89

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Lansoprazole: $10

Amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus ranitidine (Zantac), 300 mg twice daily39

5

80

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

89

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Ranitidine: $10 (6)

Lansoprazole, 30 mg twice daily for two days (pretreatment), plus amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus lansoprazole, 30 mg twice daily39

5

80

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

81

Lansoprazole (pretreatment): $10

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Lansoprazole: $10


note: Based on two separate studies.

*—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) in Red Book. Montvale, N.J.: Medical Economics Data, 2006. Cost to the patient will be higher, depending on prescription filling fee.

Information from references 38 and 39.

TABLE 3   Short-Course Therapy for Eradication of Helicobacter pylori

View Table

TABLE 3

Short-Course Therapy for Eradication of Helicobacter pylori

Treatment regimen Duration (days) Number of patients studied Population studied Eradication rate (%) Cost (generic) per day*

Bismuth subsalicylate (Pepto-Bismol), 524 mg four times a day, plus amoxicillin, 2 g four times a day, plus metronidazole (Flagyl), 500 mg four times a day, plus lansoprazole (Prevacid), 60 mg once38

1

80

H. pylori–positive patients with dyspepsia

95

Bismuth subsalicylate: $1

Amoxicillin: $9 (8 to 12)

Metronidazole: $18 (2 to 7)

Lansoprazole: $20

Clarithromycin (Biaxin), 500 mg twice daily, plus amoxicillin, 1 g twice daily, plus lansoprazole, 30 mg twice daily38

7

80

H. pylori–positive patients with dyspepsia

90

Clarithromycin: $10 (9)

Amoxicillin: $2 (2 to 3)

Amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus lansoprazole, 30 mg twice daily39

5

83

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

89

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Lansoprazole: $10

Amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus ranitidine (Zantac), 300 mg twice daily39

5

80

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

89

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Ranitidine: $10 (6)

Lansoprazole, 30 mg twice daily for two days (pretreatment), plus amoxicillin, 1 g twice daily, plus metronidazole, 400 mg twice daily, plus clarithromycin, 250 mg twice daily, plus lansoprazole, 30 mg twice daily39

5

80

H. pylori–positive patients with dyspepsia for three months or endoscopically confirmed ulcers

81

Lansoprazole (pretreatment): $10

Amoxicillin: $2 (2 to 3)

Metronidazole: $9 (1 to 4) for 500-mg strength

Clarithromycin: $10 (9)

Lansoprazole: $10


note: Based on two separate studies.

*—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) in Red Book. Montvale, N.J.: Medical Economics Data, 2006. Cost to the patient will be higher, depending on prescription filling fee.

Information from references 38 and 39.

ADVERSE EFFECTS

In a meta-analysis of 52 studies, adverse effects were noted in 39 trials comparing H. pylori eradication therapy plus an antisecretory agent versus antisecretory therapy alone (in 22 percent and 8 percent of patients, respectively [number needed to harm = 7 for H. pylori eradication]).23 The most commonly reported adverse events were nausea, vomiting, and diarrhea. A bitter or metallic taste in the mouth is associated with eradication regimens containing clarithromycin (Biaxin).28 Bismuth subsalicylate (Pepto-Bismol) may cause a temporary grayish-black discoloration of the stool.40

Special considerations

H. PYLORI ERADICATION IN CHILDREN

Endoscopy with biopsy remains the diagnostic strategy of choice in children with persistent or severe upper abdominal pain6,20,21  (Table 11622). The goal is to detect the underlying pathophysiology and cause of symptoms, not simply the presence of H. pylori. The urea breath test is the noninvasive diagnostic test of choice for H. pylori detection. The stool antigen test is an alternative, with the monoclonal antibody-based test being most reliable. Both the urea breath and stool antigen tests are reliable tests for cure.

With respect to pharmacologic treatment, the North American Society for Pediatric Gastroenterology and Nutrition recommends eradication therapy in children with an endoscopically proven duodenal or gastric ulcer with H. pylori documented via histopathology.6 Another indication is documentation of H. pylori in patients with previous ulcer disease or iron deficiency anemia.21 The guideline does not support eradication therapy or withholding treatment in children with gastritis, even if positive for H. pylori, because of a lack of data demonstrating that eradication prevents peptic ulcer disease. Nevertheless, the clinical trend, in the absence of updated practice guidelines, is to treat children who are H. pylori positive.

As in adults, various dosages of antibiotics and bismuth salts along with proton pump inhibitors in regimens ranging from seven days to six weeks have been used to treat H. pylori infection in children.41 Eradication rates of more than 90 percent have been demonstrated in children and adolescents using triple-drug therapies. Based on studies of adults and children, the recommended regimens for H. pylori eradication are listed in Table 4.6

TABLE 4

Three Drug Regimens for Eradication of Helicobacter pylori in Children

Drug regimen* Dosage

Amoxicillin

50 mg per kg per day divided twice daily, to maximum of 1 g twice daily

Clarithromycin (Biaxin)

15 mg per kg per day divided twice daily, to maximum of 500 mg twice daily

Omeprazole (Prilosec; or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily

Amoxicillin

50 mg per kg per day divided twice daily, to maximum of 1 g twice daily

Metronidazole (Flagyl)

20 mg per kg per day to maximum of 500 mg twice daily

Omeprazole (or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily

Clarithromycin

15 mg per kg per day divided twice daily, to maximum of 500 mg twice daily

Metronidazole

20 mg per kg per day to maximum of 500 mg twice daily

Omeprazole (or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily


*—All regimens consist of three drugs given simultaneously and should be prescribed initially for seven to 14 days.

Adapted with permission from Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, et al. North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000;31:496.

TABLE 4   Three Drug Regimens for Eradication of Helicobacter pylori in Children

View Table

TABLE 4

Three Drug Regimens for Eradication of Helicobacter pylori in Children

Drug regimen* Dosage

Amoxicillin

50 mg per kg per day divided twice daily, to maximum of 1 g twice daily

Clarithromycin (Biaxin)

15 mg per kg per day divided twice daily, to maximum of 500 mg twice daily

Omeprazole (Prilosec; or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily

Amoxicillin

50 mg per kg per day divided twice daily, to maximum of 1 g twice daily

Metronidazole (Flagyl)

20 mg per kg per day to maximum of 500 mg twice daily

Omeprazole (or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily

Clarithromycin

15 mg per kg per day divided twice daily, to maximum of 500 mg twice daily

Metronidazole

20 mg per kg per day to maximum of 500 mg twice daily

Omeprazole (or comparable dose of another proton pump inhibitor)

1 mg per kg per day divided twice daily, to maximum of 20 mg twice daily


*—All regimens consist of three drugs given simultaneously and should be prescribed initially for seven to 14 days.

Adapted with permission from Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, et al. North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000;31:496.

RESISTANCE

Although first-line therapy will successfully eradicate the bacteria in most infected patients, antibiotic resistance of H. pylori is a growing concern.42,43 Resistant H. pylori has been documented in cases of failed eradication therapy based on biopsy and culture results and is of great concern in patients at high risk for complications of H. pylori infection.

In one small trial, 70 percent of patients failing one or more regimens responded well to triple-drug therapy that included pantoprazole (Protonix), amoxicillin, and levofloxacin (Levaquin) for 10 days.44 A meta-analysis of current literature on treatment of resistant H. pylori showed some benefit in using quadruple-drug therapy, including the addition of clarithromycin to ranitidine (Zantac), bismuth, and amoxicillin (1 g twice daily) therapy, as well as a combination of proton-pump inhibitors (standard dosage for 10 days), bismuth, metronidazole (Flagyl), and tetracycline.43 Regimens that include rifabutin (Mycobutin), 300 mg per day, also have been successful in 38 percent of resistant cases.42

RECURRENCE

Recurrence of H. pylori infection usually is defined by a positive result on urea breath or stool antigen testing six or more months after documented successful eradication therapy. Risk factors for recurrence include nonulcer dyspepsia, persistence of chronic gastritis after eradication therapy, female sex, intellectual disability, younger age, high rates of primary infection, and higher urea breath test values.45,46 Recurrence rates worldwide vary but are lower in developed countries.47 Patients with infected spouses do not appear to have a higher risk of reinfection.48

In the primary care setting, physicians may choose to treat recurrences with an alternative eradication regimen (see Resistance), depending on individual symptoms and risk factors for complications of infection. It is too early to know whether shorter courses of eradication therapy will be associated with a higher resistance rate.

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

Although the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and H. pylori infection are independent risk factors for peptic ulcer disease, the use of NSAIDs increases the risk of peptic ulcer disease and ulcer bleeding in patients with H. pylori infection.49 Patients requiring chronic NSAID therapy who have a history of dyspepsia may benefit from testing and eradication of H. pylori before initiation of treatment to prevent these complications.

In one study, 92 patients who tested positive for H. pylori without preexisting ulcer were randomized to either eradication therapy with bismuth, tetracycline, and metronidazole or placebo for one week.50 All patients then received naproxen (Naprosyn), 750 mg daily for eight weeks. On repeat endoscopy, 26 percent of placebo-treated patients developed ulcers compared with 7 percent of patients who were pretreated with eradication therapy (NNT = 5). Symptomatic ulcers occurred in 13 percent of patients in the placebo group and in 2 percent of patients in the eradication therapy group (NNT = 9).

In a study of 660 H. pylori–positive patients without current or previous ulcer requiring long-term treatment with diclofenac (Voltaren), eradication therapy was as effective as, but no better than, antisecretory therapy and was more effective than placebo in reducing endoscopically proven ulcers (NNT = 17 to 22).51 Interestingly, there is some evidence that NSAID use may be protective, in a dose-dependent manner, against gastric cancer.52 Further studies are needed to clarify risk versus benefit for NSAID users at high risk of peptic ulcer disease and gastric cancer.

The Authors

ADRIENNE Z. ABLES, PHARM.D., is an associate professor of family medicine at the Spartanburg (S.C.) Family Medicine Residency Program. Dr. Ables received her bachelor of science degree in pharmacy from Rutgers College of Pharmacy, Piscataway, N.J., and her doctorate of pharmacy degree at the Medical University of South Carolina, Charleston.

I. SIMON, M.D., is an assistant professor of family medicine at the Spartanburg Family Medicine Residency Program. Dr. Simon received his medical degree from the Medical College of Georgia, Augusta, and completed his residency at the Columbus (Ga.) Family Medicine Residency Program.

EMILY R. MELTON, M.D., is currently in private practice in North Carolina. Dr. Melton received her medical degree from the East Carolina University School of Medicine, Greenville, N.C., and served as chief resident at the Spartanburg Family Medicine Residency Program.

Address correspondence to Adrienne Z. Ables, Pharm.D., Spartanburg Family Medicine Residency Program, 853 N. Church St., Suite 510, Spartanburg, SC 29303 (e-mail: azables@srhs.com). Reprints are not available from the authors.

Author disclosure: Nothing to disclose.

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Members of various family medicine departments develop articles for “Clinical Pharmacology.” This is one in a series coordinated by Allen F. Shaughnessy, Pharm. D., and Andrea E. Gordon, M.D., Tufts University Family Medicine Residency, Malden, Mass.


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