DENISE K. SUR, MD, and ELISE L. BUKONT, DO

Most children will be evaluated for a febrile illness by 36 months of age. If there is no evident source of fever, the child may have a serious bacterial infection, which could cause adverse effects if left untreated. Physicians should use a cautious and evidence-based approach when managing fever without a source.

BARBARA S. APGAR, MD, MS, AMANDA H. KAUFMAN, MD, UCHE GEORGE-NWOGU, MD, and ANNE KITTENDORF, MD

Women with menorrhagia may have reduced quality of life and describe a loss or reduction of daily activities. Therapies for menorrhagia include oral progestins, a levonorgestrel-releasing intrauterine device, endometrial ablation, and hysterectomy.

STEPHEN H. SCHULTZ, MD, STEPHEN W. NORTH, MD, and CLEVELAND G. SHIELDS, PhD

Schizophrenia is a debilitating mental illness that is characterized by positive and negative symptoms. Effective psychosocial and family interventions can improve outcomes, and medication can control symptoms. Physicians should actively manage side effects of drug treatment and provide guidance to all persons affected by the disease.

Patient information: "Helping a Family Member with Schizophrenia," p. 1830

MELISSA C. JONES, pharmd, BCPS

Although insulin can effectively control glucose levels, this therapy is not favored by many patients and physicians because of the risk of adverse effects. Pramlintide and exenatide are additional treatment options for patients with diabetes.