Articles

311 Targeted Therapies: A New Generation of Cancer Treatments

DAVID E. GERBER, MD

The two main types of targeted therapy, monoclonal antibodies and small molecule inhibitors, have revolutionized the treatment of cancer. With their distinct mechanisms of action and toxicities, these drugs require new approaches to determine optimal dosing, to assess patient adherence to therapy, and to evaluate treatment effectiveness.

Editorial: "The Era of Targeted Therapies," p. 294

321 Non-Neoplastic Epithelial Disorders of the Vulva

THEODORE XAVIER O'CONNELL, MD; LEENA SHANKAR NATHAN, MD; WENDY ANN SATMARY, MD; and ANDREW T. GOLDSTEIN, MD

Epithelial disorders of the vulva include lichen sclerosus, lichen planus, and lichen simplex chronicus, the latter of which is the most common. Topical corticosteroids are used to treat all three of these disorders.

Patient information: "Skin Diseases of the Vulva: What You Should Know," p. 330

331 Adolescent Substance Use and Abuse: Recognition and Management

KIM S. GRISWOLD, MD, MPH; HELEN ARONOFF, MD, MAT; JOAN B. KERNAN, BS; and LINDA S. KAHN, PhD

Screening for substance use is recommended for all adolescents. If screening is positive, physicians can conduct an in-depth evaluation or refer the patient to a subspecialist. Treatment involves multiple therapeutic components for the abuse and its comorbid disorders. Ongoing lethality assessment is essential.

339 Acute and Chronic Paronychia

DIMITRIS RIGOPOULOS, MD; GEORGE LARIOS, MD, MS; STAMATIS GREGORIOU, MD; and ALEVIZOS ALEVIZOS, MD

Treatment options for acute paronychia include warm compresses, topical antibiotics and corticosteroids, systemic antibiotics, and surgical incision and drainage. Treatment of underlying inflammation and infection is recommended, using a combination of a broad-spectrum topical antifungal agent and a corticosteroid.

Patient information: "Chronic Paronychia: What You Should Know," p. 347

Departments

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Keeping Up to Date

353 Clinical Evidence Concise

• Gastroenteritis in Children

361 Tips from Other Journals

367 Practice Guidelines

• ACCP Revises Guideline on the Diagnosis of Lung Cancer

• ACOG Releases Guidelines on Managing Herpes in Pregnancy

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Answering Clinical Questions

289 CME Quiz

355 Photo Quiz

358 FPIN's Clinical Inquiries

• Medications for Insomnia Treatment in Children

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Commentary

277 AFP Journal Club

282 Letters to the Editor

• Postpartum Appendicitis Presenting as RUQ Pain

294 Editorials

• The Era of Targeted Therapies

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Medicine and Society

285 AAFP News Now: AFP Edition

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Patient Information

330 Skin Diseases of the Vulva

347 Chronic Paronychia

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Reader Services

298 CME Center

• Search Available CME Courses

350 Evidence-Based Medicine Glossary

373 Change-of-Address Form

374 Classified Information

This article exemplifies the AAFP 2008 Annual Clinical Focus on infectious diseases: prevention, diagnosis, and management.

This article is included as part of this issue's continuing medical education (CME) activity. See CME Quiz, p. 289.

This logo designates clinical content that conforms to AAFP criteria for evidence-based continuing medical education (EB CME). EB CME is clinical content presented with practice recommendations supported by evidence that has been reviewed systematically by an AAFP-approved source.

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