Articles

457 Update on the Treatment of Tuberculosis

LISA D. INGE, PharmD, BCPS, and JOHN W. WILSON, MD

Screening options for latent tuberculosis infection include the tuberculin skin test and interferon-gamma release assays. Nine months of isoniazid is the treatment of choice for most patients with latent tuberculosis infection; active disease requires combination therapy in two phases.

Patient information: "Tuberculosis: What You Should Know," p. 469

471 Glucosamine

STEPHEN DAHMER, MD, and ROBERT M. SCHILLER, MD

Glucosamine is a popular dietary supplement used to treat osteoarthritis, particularly of the knee. Although study results have been conflicting, there is no clear evidence to recommend against its use. It is reasonable to support a 60-day trial of glucosamine sulfate, especially in patients at risk of secondary effects from other accepted treatment regimens.

Patient information: "Glucosamine and Osteoarthritis," p. 481

483 Atypical Presentations of Gastroesophageal Reflux Disease

JOEL J. HEIDELBAUGH, MD; ARVIN S. GILL, MD; R. VAN HARRISON, PhD; and TIMOTHY T. NOSTRANT, MD

Atypical gastroesophageal reflux disease can present with respiratory, nasopharyngeal, or noncardiac chest pain symptoms. Aggressive acid suppression with proton pump inhibitors twice daily before meals is the standard treatment.

489 Evaluation and Treatment of Enuresis

KALYANAKRISHNAN RAMAKRISHNAN, MD

The evaluation of nocturnal enuresis usually includes an enuresis-focused history, physical examination, and urinalysis. Treatment begins with family and patient education and reassurance and is followed by behavior therapy with or without pharmacologic therapy.

Patient information: "Enuresis: What You Should Know," p. 498

Departments

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Keeping Up to Date

503 Clinical Evidence Concise

• Diarrhea in Adults (Acute)

508 STEPS

• Zoledronic Acid (Reclast) for Osteoporosis

510 Tips from Other Journals

516 Practice Guidelines

• ACEP Policy on Evaluating Patients with Syncope in the Emergency Department

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Answering Clinical Questions

441 CME Quiz

501 Point-of-Care Guides

• Diagnosis of Anxiety Disorders in Primary Care

505 Photo Quiz

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Commentary

433 Letters to the Editor

• Safety of Kava for Patients with Mild Anxiety Disorders

444 Editorials

• Which Diuretic Should Be Used for the Treatment of Hypertension?

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Medicine and Society

437 AAFP News Now: AFP Edition

456 Close-ups

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Patient Information

469 Tuberculosis

481 Glucosamine and Osteoarthritis

498 Enuresis

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Reader Services

430 Evidence-Based Medicine Glossary

434 Corrections

CME Center

• Search Available CME Courses

466 Change-of-Address Form

519 Classified Information

This article exemplifies the AAFP 2008 Annual Clinical Focus on infectious diseases: prevention, diagnosis, and management.

This article is included as part of this issue's continuing medical education (CME) activity. See CME Quiz, p. 441.

This article is one in a series of reviews on complementary and alternative medicine.

This logo designates clinical content that conforms to AAFP criteria for evidence-based continuing medical education (EB CME). EB CME is clinical content presented with practice recommendations supported by evidence that has been reviewed systematically by an AAFP-approved source.

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