Am Fam Physician. 2010 Apr 15;81(8):933.
Related letter: Infant Formula Versus Whole Milk in Six- to 12-Month-Olds
Original Article: Infant Formula
Issue Date: April 1, 2009
Available at: http://www.aafp.org/afp/2009/0401/p565.html
to the editor: This article on infant formulas was informative and well written. However, in primary lactase deficiency (the common form of chronic lactose intolerance), the actual prevalence in infants, and subsequent management, should be further discussed.
The author mentions that most proven cases of lactose intolerance develop after 12 months of age. Limited data suggest that children younger than two years do not have primary lactase deficiency,1,2 and that the lactose intolerance present in many adults3 develops sometime after two years of age.
In adults, reports on clinical symptoms of lactose intolerance (such as diarrhea, flatulence, and abdominal pain) are prone to subjectivity.4 The same may be said for infants and children younger than two years, making patient counseling more difficult. Further complicating matters is that there may be drawbacks to switching to a lactose-free formula, because recent evidence indicates that lactose-free diets result in lower calcium absorption.4
The author mentions that many physicians suggest a trial of lactose-free formula to see if symptoms reported by the parents improve. However, there is little evidence that this practice is beneficial. Educating parents about the available data is an important part of the formula discussion, and may provide equivalent reassurance to parents as the often unnecessary (and potentially harmful) practice of switching formula.
Author disclosure: Nothing to disclose.
1. Wang Y, Harvey CB, Hollox EJ, et al. The genetically programmed down-regulation of lactase in children. Gastroenterology. 1998;114(6):1230–1236.
2. Woteki CE, Weser E, Young EA. Lactose malabsorption in Mexican-American children. Am J Clin Nutr. 1976;29(1):19–24.
3. Rings EH, Grand RJ, Büller HA. Lactose intolerance and lactase deficiency in children. Curr Opin Pediatr. 1994;6(5):562–567.
4. Heyman MB, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006;118(3):1279–1286.
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