Letters to the Editor
Hypocupremia in Patients After Gastric Bypass Surgery
FREE PREVIEW Log in or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.
FREE PREVIEW Subscribe or buy this issue. AAFP members and paid subscribers get free access to all articles.
Am Fam Physician. 2010 Jun 15;81(12):1411.
Original Article: Caring for Patients After Bariatric Surgery
Issue Date: April 15, 2006
Available at: http://www.aafp.org/afp/2006/0415/p1403.html
to the editor: In a society where obesity has taken on epidemic proportions, several therapeutic modalities have been developed to control this phenomenon. Bariatric surgery, the most aggressive and invasive treatment for obesity, has been shown to be effective in promoting weight loss. As Drs. Virji and Murr noted in their article on bariatric surgery, postoperative complications occur frequently. Metabolic disturbances are more common following surgeries that tend to produce more alteration in the gastrointestinal anatomy.1 For example, vitamin B12 and thiamine deficiencies are common after gastric bypass surgery. However, more rare metabolic deficiencies may arise as more of these surgeries are performed. One of these conditions is copper deficiency, also known as hypocupremia.
Copper is available in various food products including crab meat, fresh vegetables, fruits, nuts, seeds, and legumes.2 It is absorbed in the upper gastrointestinal tract through the duodenum and proximal jejunum.3 Copper is essential for hemoglobin synthesis, the development of connective tissue and bone, and neurologic function. Deficiency in copper may lead to vitamin B12 deficiency-like symptoms4; anemia and leukopenia with myelodysplastic manifestations; growth retardation; defective keratinization and pigmentation of the hair; neurodegenerative syndrome; mental deterioration; and scurvy-like changes in the skeleton. Symptoms may vary from mild and vague (e.g., fatigue, dizziness, nausea, shortness of breath) to more pronounced and serious (e.g., ataxia with severe gait disturbance, mental deterioration, respiratory arrest).
Treatment of hypocupremia consists of the prompt reversal of the deficiency with intravenous copper infusion, oral supplementation of copper, or both, depending on the severity of the condition. Although the hematologic manifestations, including pancytopenia and myelodysplasia, promptly improve with copper therapy,5 the neurologic improvement may show varying degrees of response depending on the duration and severity of the condition.6
Family physicians are expected to care for a growing number of patients after gastric bypass, and will likely encounter an increasing number of patients with hypocupremia. Prompt recognition and treatment of this condition is essential to prevent the development of permanent neurologic deficits.4,6
Author disclosure: Nothing to disclose.
1. Prodan CI, Bottomley SS, Vincent AS, et al. Copper deficiency after gastric surgery: a reason for caution. Am J Med Sci. 2009;337(4):256–258.
2. Diet and Health: Implications for Reducing Chronic Disease Risk. National Academy Press, Washington, DC;1989.
3. Tan JC, Burns DL, Jones HR. Severe ataxia, myelopathy, and peripheral neuropathy due to acquired copper deficiency in a patient with history of gastrectomy. JPEN J Parenter Enteral Nutr. 2006;30(5):446–450.
4. Kumar N, Gross JB Jr, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 2004;63(1):33–39.
5. Camblor M, De la Cuerda C, Bretón I, Pérez-Rus G, Alvarez S, García P. Copper deficiency with pancytopenia due to enteral nutrition through jejunostomy. Clin Nutr. 1997;16(3):129–131.
6. Prodan CI, Holland NR, Wisdom PJ, Burstein SA, Bottomley SS. CNS demyelination associated with copper deficiency and hyperzincemia. Neurology. 2002;59(9):1453–1456.
Send letters to Kenneth W. Lin, MD, MPH, Associate Deputy Editor for AFP Online, e-mail: email@example.com, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680.
Please include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.
Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the American Academy of Family Physicians permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.
Copyright © 2010 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact firstname.lastname@example.org for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions