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Ulcer on Lower Lip of Deployed Serviceman



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Am Fam Physician. 2011 Mar 1;83(5):601-602.

  Related letter: Histologic, Microbial Testing to Confirm Dermatologic Conditions.

A 46-year-old serviceman deployed to Iraq presented with a papule on his lower lip that had developed over four weeks. Two days after the patient nicked his lip with a razor, a small, red, tender bump appeared. Over the next few weeks, the bump became firmer and slowly enlarged.

Although the patient had received multiple insect bites in the previous weeks, he did not recall any on his lips. He had no fever or chills. He had used smokeless tobacco for 20 years and had moderate sun exposure as a child and adult. Physical examination revealed an indurated, 4-mm papule with a dry central ulcer (see accompanying figure). There was no regional lymphadenopathy, and the patient was otherwise healthy.

Question

Based on the patient's history and physical examination, which one of the following is the most likely diagnosis?

A. Arthropod envenomation necrosis.

B. Cutaneous leishmaniasis.

C. Ecthyma.

D. Ecthyma gangrenosum.

E. Squamous cell carcinoma.

Discussion

The answer is C: ecthyma. Ecthyma is a cutaneous bacterial infection that extends into the dermis. It usually occurs on disrupted skin,1 beginning as a vesicle or vesicopustule, then developing a hemorrhagic crust.2 Ecthyma is classically associated with group A streptococci, but staphylococci may also be present. Because the infection extends into the dermis, scarring may result. Ecthyma is treated using systemic antibiotics with good gram-positive coverage.3

Arthropod envenomation from several types of stinging insects can quickly cause large, painful ulcers that are surrounded by erythema. Central eschar may develop. However, it is unlikely that a sting on the patient's lip would go unnoticed. Insect bites and stings with or without envenomation can also serve as portals for infection, including ecthyma.4

Leishmaniasis is caused by intracellular parasites that gain entry during an arthropod bite. The disease can manifest as primary local lesions, delayed mucocutaneous lesions, or visceral leishmaniasis. The classic description of leishmaniasis is a nonhealing ulcer with a rolled border. Because of this patient's travel history, leishmaniasis must be carefully considered,5 especially if there is no response to initial therapy.

Ecthyma gangrenosum is a pseudomonal infection leading to a papule with hemorrhagic crust similar to ecthyma. It results from hematogenous spread of Pseudomonas, which is not suggested by the patient's history or examination. Ecthyma gangrenosum usually occurs in persons who are immunosuppressed or gravely ill.3 When ecthyma gangrenosum is suspected, biopsy with deep tissue Gram stain and culture can be used for diagnosis.

Squamous cell carcinoma often occurs on sun-exposed skin. It presents as a slowly progressive, scaly papule. The quick progression of the patient's lesion and the history of trauma to his lip are more consistent with an infectious process than squamous cell carcinoma.

Summary Table

Condition Characteristics

Arthropod envenomation necrosis

Large, painful, rapidly developing ulcers surrounded by erythema; may develop central eschar

Cutaneous leishmaniasis

A polymorphic eruption, but classically described as a nonhealing ulcer with a rolled border at the site of an arthropod bite

Ecthyma

Begins as a vesicle or vesicopustule, then develops hemorrhagic crust

Ecthyma gangrenosum

Papule with hemorrhagic crust resembling ecthyma; deep tissue Gram stain and culture can confirm diagnosis, if needed

Squamous cell carcinoma

Slowly progressive, scaly papule on sun-exposed areas of skin

Summary Table

View Table

Summary Table

Condition Characteristics

Arthropod envenomation necrosis

Large, painful, rapidly developing ulcers surrounded by erythema; may develop central eschar

Cutaneous leishmaniasis

A polymorphic eruption, but classically described as a nonhealing ulcer with a rolled border at the site of an arthropod bite

Ecthyma

Begins as a vesicle or vesicopustule, then develops hemorrhagic crust

Ecthyma gangrenosum

Papule with hemorrhagic crust resembling ecthyma; deep tissue Gram stain and culture can confirm diagnosis, if needed

Squamous cell carcinoma

Slowly progressive, scaly papule on sun-exposed areas of skin

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Navy Medical Department or the U.S. Navy at large.

Address correspondence to Donald Shenenberger, CDR, MC, USN, at Donald.shenenberger@med.navy.mil. Reprints are not available from the authors.

Author disclosure: Nothing to disclose.


REFERENCES

1. Wasserzug O, Valinsky L, Klement E, et al. A cluster of ecthyma outbreaks caused by a single clone of invasive and highly infective Streptococcus pyogenes. Clin Infect Dis. 2009;48(9):1213–1219.

2. Bolognia J, Jorizzo JL, Rapini RP, eds. Dermatology. 2nd ed. St. Louis, Mo.: Mosby; 2008.

3. James WD, Berger TG, Elston DM, Odom RB, eds. Andrew's Diseases of the Skin: Clinical Dermatology.10th ed. Philadelphia, Pa.: Saunders Elsevier; 2006.

4. Hochedez P, Canestri A, Lecso M, Valin N, Bricaire F, Caumes E. Skin and soft tissue infections in returning travelers. Am J Trop Med Hyg. 2009;80(3):431–434.

5. AlSamarai AM, AlObaidi HS. Cutaneous leishmaniasis in Iraq. J Infect Dev Ctries. 2009;3(2):123–129.

Contributing editor for Photo Quiz is John E. Delzell, Jr., MD, MSPH.

A collection of Photo Quizzes published in AFP is available at http://www.aafp.org/afp/photoquiz.

The editors of AFP welcome submissions for Photo Quiz. Guidelines for preparing and submitting a Photo Quiz manuscript can be found in the Authors' Guide at http://www.aafp.org/afp/photoquizinfo. To be considered for publication, submissions must meet these guidelines. E-mail submissions to afpphoto@aafp.org.



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