Summary of the NIAID-Sponsored Food Allergy Guidelines



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Patients with suspected food allergies are commonly seen in clinical practice. Although up to 15 percent of parents believe their children have food allergies, these allergies have been confirmed in only 1 to 3 percent of all Americans. Family physicians must be able to separate true food allergies from food intolerance, food dislikes, and other conditions that mimic food allergy. The most common foods that produce allergic symptoms are milk, eggs, seafood, peanuts, and tree nuts. Although skin testing and in vitro serum immunoglobulin E assays may help in the evaluation of suspected food allergies, they should not be performed unless the clinical history suggests a specific food allergen to which testing can be targeted. Furthermore, these tests do not confirm food allergy. Confirmation requires a positive food challenge or a clear history of an allergic reaction to a food and resolution of symptoms after eliminating that food from the diet. More than 70 percent of children will outgrow milk and egg allergies by early adolescence, whereas peanut allergies usually remain throughout life. The most serious allergic response to food allergy is anaphylaxis. It requires emergency care that should be initiated by the patient or family using an epinephrine autoinjector, which should be carried by anyone with a diagnosed food allergy. These and other recommendations presented in this article are derived from the Guidelines for the Diagnosis and Management of Food Allergy in the United States, published by the National Institute of Allergy and Infectious Diseases.

Food allergy is a common cause of diagnostic confusion in primary care.1 To help develop a standardized approach to evaluation, diagnosis, and management, the National Institute of Allergy and Infectious Diseases (NIAID) sponsored an expert panel to generate clinical practice guidelines on food allergy. The full guidelines are available at http://www.niaid.nih.gov/topics/foodallergy/clinical/Pages/default.aspx. This article contains selected data and clinical recommendations from those guidelines.2

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References

A thorough medical history supplemented by oral food challenge tests should be used to establish a diagnosis of food allergy.

C

2, 2729

When food challenge tests are unavailable, or when the food allergy has resulted in anaphylaxis, a diagnosis should be based on a definitive history and absence of symptoms when the causative food is eliminated from the diet.

C

2

Skin prick tests and tests measuring total serum immunoglobulin E (IgE) or allergen-specific serum IgE levels are not sufficient to make a diagnosis of food allergy.

C

2, 2729

Influenza vaccine (not the live attenuated type) can be given to patients with egg allergies whose reactions are limited to urticaria.

C

2, 36

All patients with a history of food allergy–induced anaphylaxis should be given and taught how to use an epinephrine autoinjector and encouraged to wear medical alert jewelry and carry an anaphylaxis wallet card.

C

2, 41, 42


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.org/afpsort.xml.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

View Table

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References

A thorough medical history supplemented by oral food challenge tests should be used to establish a diagnosis of food allergy.

C

2, 2729

When food challenge tests are unavailable, or when the food allergy has resulted in anaphylaxis, a diagnosis should be based on a definitive history and absence of symptoms when the causative food is eliminated from the diet.

C

2

Skin prick tests and tests measuring total serum immunoglobulin E (IgE) or allergen-specific serum IgE levels are not sufficient to make a diagnosis of food allergy.

C

2, 2729

Influenza vaccine (not the live attenuated type) can be given to patients with egg allergies whose reactions are limited to urticaria.

C

2, 36

All patients with a history of food allergy–induced anaphylaxis should be given and taught how to use an epinephrine autoinjector and encouraged to wear medical alert jewelry and carry an anaphylaxis wallet card.

C

2, 41, 42


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.org/afpsort.xml.

The guidelines do not discuss celiac disease or food intolerances such as those that result from lactose deficiency, nor do they provide public health recommendations for schools and other public settings. Readers are encouraged to refer to the full guidelines when implementing any of the recommendations discussed in this article.

Definition and Prevalence

Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food.1,2 A food is defined is any substance, whether processed, semiprocessed, or raw, that is intended for human consumption. This definition includes drinks, chewing gum, food additives, and dietary supplements. It does not include drugs, tobacco products, or cosmetics; adverse health effects arising from the use of these products are not covered in the guidelines.2

Although more than 170 foods have been reported to cause immunoglobulin E (IgE)-mediated reactions, most prevalence studies have focused only on the most common foods that cause allergies. In the United States, these include hen’s eggs (hereafter referred to as eggs), cow’s milk, peanuts, tree nuts, soy, wheat, fish, and crustacean shellfish.2 Allergic reactions associated with these foods are typically caused by proteins that elicit specific immunologic reactions.

The true prevalence of allergy to these foods has been difficult to ascertain, in part because study definitions and designs have varied widely, and because reported prevalence rates have changed over time.28 In addition, studies reporting confirmed cases of food allergy indicate lower rates than studies that rely on parent-reported rates, which are often unconfirmed or possible cases25  (Table 137,914). Up to 15 percent of parents believe their children have food allergies.13 These allergies have been confirmed in only 1 to 3 percent of all Americans.24 Family physicians must be able to separate true food allergies from food intolerance, food dislikes, and other conditions that mimic food allergy.

Table 1.

Food Allergy Prevalence in Children and Adults

Food Parent-/patient-reported prevalence Prevalence in studies that include only confirmed cases

Milk

6.5% (children),5 1.5% (adults)7

0.9% (all ages)3,4,12

Eggs

1.0% (children),13 1.0% (adults)3,4

0.3% (all ages)9

Seafood

0.6% (children),6 2.8% (adults)6

Unknown

Peanuts

0.6% (all ages)10,14

Unknown

Tree nuts

0.4% (all ages)11

Unknown


Information from references 3 through 7, and 9 through 14.

Table 1.   Food Allergy Prevalence in Children and Adults

View Table

Table 1.

Food Allergy Prevalence in Children and Adults

Food Parent-/patient-reported prevalence Prevalence in studies that include only confirmed cases

Milk

6.5% (children),5 1.5% (adults)7

0.9% (all ages)3,4,12

Eggs

1.0% (children),13 1.0% (adults)3,4

0.3% (all ages)9

Seafood

0.6% (children),6 2.8% (adults)6

Unknown

Peanuts

0.6% (all ages)10,14

Unknown

Tree nuts

0.4% (all ages)11

Unknown


Information from references 3 through 7, and 9 through 14.

A pooled overall prevalence of self-reported food allergy to cow’s milk, eggs, peanuts, fish, or crustacean shellfish was 13 percent for adults and 12 percent for children.3 However, when diagnosis was made in the context of confirmed cases in double-blind placebo-controlled food challenges, the rate dropped to 3 percent for both children and adults.4 Allergic sensitization, as indicated by a positive skin prick test, occurs at a rate that greatly exceeds that of clinical (symptomatic) food allergy. Thus, skin prick tests should not be used to determine food allergy prevalence.

A number of specific clinical syndromes may occur as a result of food allergy (Table 21522). The most serious is anaphylaxis, which occurs in about one to 70 per 100,000 persons in the general population, and in 13 to 65 percent of suspected food allergy cases.18,19,23 Asthma and atopic dermatitis are associated with food allergies, but a causal link between food allergies and these disorders has not been established.

Table 2.

Clinical Syndromes Caused by Food Allergy

Cutaneous reactions

Acute urticaria is a common manifestation of IgE-mediated food allergy characterized by the appearance of pruritic wheals of various sizes that develop rapidly after ingesting the problem food. Food allergy is not the most common cause of this cutaneous reaction, and chronic urticaria (lasting three months or longer) is not a manifestation of IgE-mediated food allergy and is rarely caused by food allergies.15

Allergic contact dermatitis is a cell-mediated allergic reaction caused by haptens in foods.

Angioedema often occurs with acute urticaria and is typically IgE-mediated. Symptoms include nonpitting, nonpruritic, swelling of the subcutaneous tissues, face, hands, buttocks, genitals, or larynx. Laryngeal angioedema is a medical emergency and is often a manifestation of anaphylaxis.15

Atopic dermatitis/eczema is often associated with food allergy. Food avoidance does not generally alter the course of the reaction, but it may reduce the severity of atopic dermatitis.16,17

Contact urticaria can be IgE- or non–IgE-mediated. In IgE-mediated contact urticaria, substances in food trigger cutaneous mast cells to release histamine and other mediators.17

Food-induced anaphylaxis

Food-induced anaphylaxis is an IgE-mediated, rapid-onset, potentially life-threatening systemic condition.18

GI food allergies19

Dietary protein-induced proctitis/proctocolitis occurs in healthy infants with visible blood in the stool. Lack of additional GI symptoms differentiates this disorder from other GI disorders. This is a non–IgE-mediated food allergy that may occur following feedings with breast, cow’s, goat’s, or soy milk.20

Eosinophilic esophagitis involves localized eosinophilic inflammation of the esophagus and is IgE- and non–IgE-mediated. In children, eosinophilic esophagitis causes feeding disorders, vomiting, reflux symptoms, and abdominal pain. In adolescents and adults, it presents with dysphagia and esophageal food impactions. It may be difficult to identify the food causing the allergy.21

Eosinophilic gastroenteritis is IgE- and non–IgE-mediated with eosinophilic infiltration of the gut, and may be localized or widespread. Food avoidance may reduce the severity of eosinophilic esophagitis and eosinophilic gastroenteritis.20

Food protein–induced enterocolitis syndrome is non–IgE-mediated and results in severe dehydration caused by vomiting and diarrhea from intake of cow’s or soy milk or rice, oats, or other grains.20

Immediate GI hypersensitivity refers to an IgE-mediated food allergy in which upper GI symptoms occur within minutes and lower GI symptoms immediately or within hours. It often occurs in patients experiencing anaphylaxis.

Oral allergy syndrome is usually caused by a cross-reactivity between aeroallergens such as pollens and certain fruits or vegetables. When eating these fruits or vegetables, symptoms of swelling or tingling limited to the lips or oropharynx can occur (which resolve if the food is swallowed or spit out). Cooking the food will prevent the reaction, and progression to other symptoms is rare.

Respiratory manifestations

Respiratory manifestations (of the upper and lower respiratory tracts) of IgE-mediated food allergies are important components of anaphylaxis, but are uncommon in isolation.22


GI = gastrointestinal; IgE = immunoglobulin E.

Information from references 15 through 22.

Table 2.   Clinical Syndromes Caused by Food Allergy

View Table

Table 2.

Clinical Syndromes Caused by Food Allergy

Cutaneous reactions

Acute urticaria is a common manifestation of IgE-mediated food allergy characterized by the appearance of pruritic wheals of various sizes that develop rapidly after ingesting the problem food. Food allergy is not the most common cause of this cutaneous reaction, and chronic urticaria (lasting three months or longer) is not a manifestation of IgE-mediated food allergy and is rarely caused by food allergies.15

Allergic contact dermatitis is a cell-mediated allergic reaction caused by haptens in foods.

Angioedema often occurs with acute urticaria and is typically IgE-mediated. Symptoms include nonpitting, nonpruritic, swelling of the subcutaneous tissues, face, hands, buttocks, genitals, or larynx. Laryngeal angioedema is a medical emergency and is often a manifestation of anaphylaxis.15

Atopic dermatitis/eczema is often associated with food allergy. Food avoidance does not generally alter the course of the reaction, but it may reduce the severity of atopic dermatitis.16,17

Contact urticaria can be IgE- or non–IgE-mediated. In IgE-mediated contact urticaria, substances in food trigger cutaneous mast cells to release histamine and other mediators.17

Food-induced anaphylaxis

Food-induced anaphylaxis is an IgE-mediated, rapid-onset, potentially life-threatening systemic condition.18

GI food allergies19

Dietary protein-induced proctitis/proctocolitis occurs in healthy infants with visible blood in the stool. Lack of additional GI symptoms differentiates this disorder from other GI disorders. This is a non–IgE-mediated food allergy that may occur following feedings with breast, cow’s, goat’s, or soy milk.20

Eosinophilic esophagitis involves localized eosinophilic inflammation of the esophagus and is IgE- and non–IgE-mediated. In children, eosinophilic esophagitis causes feeding disorders, vomiting, reflux symptoms, and abdominal pain. In adolescents and adults, it presents with dysphagia and esophageal food impactions. It may be difficult to identify the food causing the allergy.21

Eosinophilic gastroenteritis is IgE- and non–IgE-mediated with eosinophilic infiltration of the gut, and may be localized or widespread. Food avoidance may reduce the severity of eosinophilic esophagitis and eosinophilic gastroenteritis.20

Food protein–induced enterocolitis syndrome is non–IgE-mediated and results in severe dehydration caused by vomiting and diarrhea from intake of cow’s or soy milk or rice, oats, or other grains.20

Immediate GI hypersensitivity refers to an IgE-mediated food allergy in which upper GI symptoms occur within minutes and lower GI symptoms immediately or within hours. It often occurs in patients experiencing anaphylaxis.

Oral allergy syndrome is usually caused by a cross-reactivity between aeroallergens such as pollens and certain fruits or vegetables. When eating these fruits or vegetables, symptoms of swelling or tingling limited to the lips or oropharynx can occur (which resolve if the food is swallowed or spit out). Cooking the food will prevent the reaction, and progression to other symptoms is rare.

Respiratory manifestations

Respiratory manifestations (of the upper and lower respiratory tracts) of IgE-mediated food allergies are important components of anaphylaxis, but are uncommon in isolation.22


GI = gastrointestinal; IgE = immunoglobulin E.

Information from references 15 through 22.

Natural History

The time course of food allergy resolution in children varies by food, and may occur as late as the teenage years.912,14 By adolescence, 85 percent or more of children who have allergies to cow’s milk will tolerate cow’s milk,7 and up to 70 percent will outgrow egg allergies,16 but only about 20 percent will eventually tolerate tree nuts and peanuts.1,2,10,11

A high initial level of allergen-specific IgE against a food is associated with a lower rate of resolution of clinical food allergies over time.2 Food allergies in adults can reflect persistence of childhood food allergies or de novo sensitization to food allergens encountered after childhood, most commonly seafood. Although there is a shortage of data from U.S. studies, food allergies that start in adult life tend to persist and not resolve.2,12,16

Atopic Dermatitis, Asthma, and Food Allergy

Family history of atopy and the presence of atopic dermatitis are risk factors for the development of sensitization to food allergens and the development of food allergy. Asthma, however, is a stronger risk factor.

Food allergies may coexist with asthma, and asthma is the risk factor most commonly associated with severe food allergy.2426 Patients with food allergies and asthma have higher rates of emergency department visits and hospitalizations for asthma, and also have a higher risk of death from exercise-induced anaphylaxis.2,23,24 Exercise-induced anaphylaxis typically occurs within 30 minutes or less, but sometimes up to six hours after ingesting a specific food, with symptoms beginning after initiation of exercise. In this syndrome, ingestion of the specific food and exercise are required. Either factor alone does not produce symptoms.1,25

When Should Food Allergy Be Suspected?

Food allergy should be considered in persons presenting with anaphylaxis or with any combination of the symptoms listed in Table 3,24 occurring within minutes to hours of ingesting food. This should especially be considered in young children, or if symptoms have followed the ingestion of a specific food on more than one occasion. The severity of allergic reactions to foods, however, is multifactorial and variable. The extent of a reaction cannot be accurately predicted by the severity of past reactions.

Table 3.

Symptoms of Food Allergy Reactions

Organ system Immediate symptoms Delayed symptoms

Cardiovascular

Dizziness

Fainting

Hypotension

Loss of consciousness

Tachycardia (occasionally bradycardia in anaphylaxis)

Cutaneous

Angioedema

Erythema

Morbilliform eruption

Pruritus

Urticaria

Angioedema

Eczematous rash

Erythema

Flushing

Morbilliform eruption

Pruritus

Gastrointestinal (lower)

Colicky abdominal pain

Diarrhea

Nausea

Reflux

Vomiting

Abdominal pain

Diarrhea

Hematochezia

Irritability and food refusal with weight loss (young children)

Nausea or vomiting

Reflux

Gastrointestinal (oral)

Angioedema of the lips, tongue, or palate

Oral pruritus

Tongue swelling

Ocular

Conjunctival erythema

Periorbital edema

Pruritus

Tearing

Conjunctival erythema

Periorbital edema

Pruritus

Tearing

Respiratory (lower)

Accessory muscle use

Chest tightness

Cough

Dyspnea

Intercostal retractions

Wheezing

Cough

Dyspnea

Wheezing

Respiratory (upper)

Dry staccato cough

Hoarseness

Laryngeal edema

Nasal congestion

Rhinorrhea

Sneezing


Information from references 2 through 4.

Table 3.   Symptoms of Food Allergy Reactions

View Table

Table 3.

Symptoms of Food Allergy Reactions

Organ system Immediate symptoms Delayed symptoms

Cardiovascular

Dizziness

Fainting

Hypotension

Loss of consciousness

Tachycardia (occasionally bradycardia in anaphylaxis)

Cutaneous

Angioedema

Erythema

Morbilliform eruption

Pruritus

Urticaria

Angioedema

Eczematous rash

Erythema

Flushing

Morbilliform eruption

Pruritus

Gastrointestinal (lower)

Colicky abdominal pain

Diarrhea

Nausea

Reflux

Vomiting

Abdominal pain

Diarrhea

Hematochezia

Irritability and food refusal with weight loss (young children)

Nausea or vomiting

Reflux

Gastrointestinal (oral)

Angioedema of the lips, tongue, or palate

Oral pruritus

Tongue swelling

Ocular

Conjunctival erythema

Periorbital edema

Pruritus

Tearing

Conjunctival erythema

Periorbital edema

Pruritus

Tearing

Respiratory (lower)

Accessory muscle use

Chest tightness

Cough

Dyspnea

Intercostal retractions

Wheezing

Cough

Dyspnea

Wheezing

Respiratory (upper)

Dry staccato cough

Hoarseness

Laryngeal edema

Nasal congestion

Rhinorrhea

Sneezing


Information from references 2 through 4.

Diagnosis

Diagnosis of food allergy requires a clear and specific history that is confirmed by a food challenge test.2 Parent and patient reports of food allergy must be confirmed, because multiple studies demonstrate that 50 to 90 percent of self-reported food allergies are not actually allergies.13 The general approach to diagnosis is outlined in Figure 1.2

Evaluation of Suspected Food Allergy

Figure 1.

Algorithm for the evaluation of suspected food allergy. (IgE = immunoglobulin E.)

Information from reference 2.

View Large

Evaluation of Suspected Food Allergy


Figure 1.

Algorithm for the evaluation of suspected food allergy. (IgE = immunoglobulin E.)

Information from reference 2.

Evaluation of Suspected Food Allergy


Figure 1.

Algorithm for the evaluation of suspected food allergy. (IgE = immunoglobulin E.)

Information from reference 2.

FOOD CHALLENGE

The double-blind placebo-controlled food challenge is regarded as the recommended method of diagnosis. A single-blind and open food challenge may be considered diagnostic in a clinical setting when the food challenge elicits no symptoms (negative challenge), or when there are objective symptoms (positive challenge) that correlate with medical history and are supported by laboratory tests.2

ELIMINATION DIETS

When food challenge tests are not practical or are unavailable, or when the patient has a confirmed history of anaphylaxis after ingesting a particular food, a diagnosis may be based on a definitive history and an absence of symptoms when the causative food is eliminated from the diet.2 When multiple food allergies are suspected, however, elimination of multiple foods may put the person at risk of nutritional deficiency. In such cases, it is appropriate to refer the patient to a specialist who is able to perform an oral food challenge. Oral food challenges should be performed only by trained health care professionals in a setting that provides immediate access to resuscitative equipment.2729

SKIN TESTS AND LABORATORY TESTS

It is important to emphasize that skin prick tests and tests that measure total serum levels of IgE or allergen-specific IgE only detect the presence of allergic sensitization. They are not sufficient by themselves to make a diagnosis of food allergy. Almost one-half of the U.S. population has detectable allergen-specific IgE against a food allergen, but the overall prevalence of clinical food allergy is only about 4 to 6 percent.2,27,28,30 These tests should be used only when targeted at foods likely to cause a food allergy based on a history that may include the use of food diaries to identify offending foods.2

Tests for which there are few or no data to support utility in diagnosing IgE-mediated food allergies are listed in Table 4.2 Use of these tests should be discouraged.

Table 4.

Unproven Tests for Diagnosing Food Allergy

Allergen-specific immunoglobulin G

Applied kinesiology

Basophil histamine release/activation

Cytotoxic assays

Electrodermal test

Endoscopic allergen provocation

Facial thermography

Gastric juice analysis

Hair analysis

Intradermal allergy testing

Mediator release assay (LEAP [lifestyle, eating and performance diet]) provocation neutralization


Adapted with permission from Boyce JA, Assa’ad A, Burks AW, et al.; NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-Sponsored Expert Panel. J Allergy Clin Immunol. 2010;126(6 suppl):S24.

Table 4.   Unproven Tests for Diagnosing Food Allergy

View Table

Table 4.

Unproven Tests for Diagnosing Food Allergy

Allergen-specific immunoglobulin G

Applied kinesiology

Basophil histamine release/activation

Cytotoxic assays

Electrodermal test

Endoscopic allergen provocation

Facial thermography

Gastric juice analysis

Hair analysis

Intradermal allergy testing

Mediator release assay (LEAP [lifestyle, eating and performance diet]) provocation neutralization


Adapted with permission from Boyce JA, Assa’ad A, Burks AW, et al.; NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-Sponsored Expert Panel. J Allergy Clin Immunol. 2010;126(6 suppl):S24.

Management

ELIMINATION

The primary treatment of food allergies is prevention by eliminating ingestion of the offending food. When the food is a mainstay of the diet or multiple foods must be eliminated, nutritional counseling and regular growth monitoring are essential.

To facilitate elimination of specific foods, the NIAID guidelines suggest that patients with food allergies and their caregivers receive education and training on how to interpret ingredient lists on food labels and how to recognize incomplete labeling of ingredients. Products with voluntary precautionary labeling, such as “this product may contain trace amounts of” an allergen, or “this product is made in a facility that uses” particular allergens, should be avoided. Age- and culturally-appropriate information on food allergen avoidance should be provided, with emergency management that includes immediate therapy for anaphylaxis. Table 5 provides a list of resources for patients and caregivers.

Table 5.

Food Allergy Resources

Guidelines for the Diagnosis and Management of Food Allergies in the United States

http://www.niaid.nih.gov/topics/foodAllergy/clinical/Pages/default.aspx

note: This Web site also contains a summary prepared by the National Institute of Allergy and Infectious Diseases to be used as educational material for patients, families, and caregivers.

Published version of the guidelines and summary of the expert panel report from the Journal of Allergy and Clinical Immunology

http://www.jacionline.org/article/S0091-6749(10)01566-6/fulltext

http://www.jacionline.org/article/S0091-6749(10)01569-1/fulltext

Prevalence, Natural History, Diagnosis, and Treatment of Food Allergy: A Systematic Review of the Evidence

http://www.rand.org/pubs/working_papers/WR757-1.html

The Diagnosis and Management of Anaphylaxis: An Updated Practice Parameter

http://download.journals.elsevierhealth.com/pdfs/journals/0091-6749/PIIS0091674905001156.pdf

Example of an anaphylaxis emergency action plan

http://www.aaaai.org/conditions-and-treatments/allergies/anaphylaxis.aspx

Myths about food allergies

http://familydoctor.org/familydoctor/en/diseases-conditions/food-allergies.html

The Food Allergy & Anaphylaxis Network

Telephone: 800-929-4040

http://www.foodallergy.org

Table 5.   Food Allergy Resources

View Table

Table 5.

Food Allergy Resources

Guidelines for the Diagnosis and Management of Food Allergies in the United States

http://www.niaid.nih.gov/topics/foodAllergy/clinical/Pages/default.aspx

note: This Web site also contains a summary prepared by the National Institute of Allergy and Infectious Diseases to be used as educational material for patients, families, and caregivers.

Published version of the guidelines and summary of the expert panel report from the Journal of Allergy and Clinical Immunology

http://www.jacionline.org/article/S0091-6749(10)01566-6/fulltext

http://www.jacionline.org/article/S0091-6749(10)01569-1/fulltext

Prevalence, Natural History, Diagnosis, and Treatment of Food Allergy: A Systematic Review of the Evidence

http://www.rand.org/pubs/working_papers/WR757-1.html

The Diagnosis and Management of Anaphylaxis: An Updated Practice Parameter

http://download.journals.elsevierhealth.com/pdfs/journals/0091-6749/PIIS0091674905001156.pdf

Example of an anaphylaxis emergency action plan

http://www.aaaai.org/conditions-and-treatments/allergies/anaphylaxis.aspx

Myths about food allergies

http://familydoctor.org/familydoctor/en/diseases-conditions/food-allergies.html

The Food Allergy & Anaphylaxis Network

Telephone: 800-929-4040

http://www.foodallergy.org

FOLLOW-UP TESTING

Because some food allergies tend to disappear with age, follow-up testing for children with these allergies should be performed based on the specific food to which the child is allergic. Whether testing is performed annually or at other intervals depends on the food in question, the age of the child, and the intervening clinical history. Consultation with a food allergy specialist may be helpful.2

MEDICATIONS AND IMMUNOTHERAPY

There are no recommended medications to prevent IgE- or non–IgE-mediated allergic reactions to food. Allergen-specific immunotherapy or immunotherapy with cross-reacting allergens is not recommended to treat food allergy. There have been promising research findings from allergen-specific immunotherapy clinical trials, but the safety of this therapy has not yet been thoroughly established. Use of allergen-specific immunotherapy is not recommended outside of the setting of a clinical trial approved by the U.S. Food and Drug Administration.31,32

CROSS-REACTING ALLERGENS

Patients at risk of developing food allergies, such as those with a biologic parent or sibling who has a food allergy, or persons who have a history of food allergy, allergic rhinitis, asthma, or atopic dermatitis, do not need to limit their exposure to potential nonfood allergens, such as dust, pet dander, or pollens (Table 61). They also do not need to limit exposure to foods that may be cross-reactive with other major food allergens.2 It has been proposed that exposure to nonfood allergens and cross-reactive foods could increase the risk of developing food allergy, but there is little evidence to support this hypothesis, and unnecessary food avoidance can result in inadequate nutrient intake and growth deficits.2

Table 6.

Environmental Allergens That Cross-React with Food Allergens

Environmental allergen Cross-reactive foods

Birch pollen

Carrots, celery, fresh fruit (e.g., apples, cherries, nectarines, peaches, pears), hazelnuts, parsnips, potatoes

Grass pollen

Kiwi, tomatoes

Ragweed pollen

Bananas, melons (e.g., cantaloupe, honeydew, watermelon)


Information from reference 1.

Table 6.   Environmental Allergens That Cross-React with Food Allergens

View Table

Table 6.

Environmental Allergens That Cross-React with Food Allergens

Environmental allergen Cross-reactive foods

Birch pollen

Carrots, celery, fresh fruit (e.g., apples, cherries, nectarines, peaches, pears), hazelnuts, parsnips, potatoes

Grass pollen

Kiwi, tomatoes

Ragweed pollen

Bananas, melons (e.g., cantaloupe, honeydew, watermelon)


Information from reference 1.

Preventing Food Allergies in Children

No dietary restrictions should be necessary during pregnancy or lactation as a strategy for preventing the development or clinical course of food allergy in the infant. All infants should be exclusively breastfed until four to six months of age, unless breastfeeding is contraindicated for medical reasons.2,33 If breastfeeding is contraindicated, soy infant formula (instead of cow’s–milk infant formula) is not recommended as a strategy for preventing the development of food allergies or modifying its clinical course in at-risk infants.2 The introduction of solid foods should not be delayed beyond six months of age. Potentially allergenic foods may also be introduced by this time.34,35

Immunizations for Patients with Egg Allergy

Persons with egg allergy, even those with a history of severe reactions, can receive vaccines for measles, mumps, rubella, and varicella.2 Conversely, rabies and yellow fever vaccines should not be given to patients with a history of hives, angioedema, allergic asthma, or systemic anaphylaxis to egg, unless an allergy evaluation is performed first.

For influenza vaccines, health care professionals should follow the current vaccine recommendations from the Advisory Committee on Immunization Practices (ACIP). As of 2011, the ACIP encourages persons with egg allergy whose reactions are limited to urticaria to receive seasonal influenza vaccines.36 There are insufficient data to comment on the use of the live attenuated influenza vaccine in these persons.

It should be noted that a negative skin prick test to egg allergen does not accurately predict safety of influenza vaccination. About 5 percent of patients with negative skin prick test results will have a systemic reaction to vaccines containing egg.37 Precautionary skin testing with a vaccine is more likely to identify allergic sensitivities to a nonegg vaccine component than to egg proteins present in the vaccine. The ACIP does not recommend such precautionary skin testing before receiving seasonal influenza vaccines.

Anaphylaxis

Anaphylaxis has a rapid onset and may cause death. Treatment for food-induced anaphylaxis should focus on initiating treatment promptly after the onset of symptoms; intramuscular epinephrine as a first-line therapy; and other medical treatments as an adjunct to epinephrine.3840  Table 7 outlines pharmacologic treatment for anaphylaxis in outpatient and hospital settings.2

Table 7.

Drugs for Anaphylaxis Management

Outpatient setting

First-line treatment:

Epinephrine, IM; autoinjector or 1:1,000 solution

22 to 56 lb (10 to 25 kg): 0.15-mg epinephrine autoinjector, IM (anterolateral thigh)

> 56 lb: 0.3-mg epinephrine autoinjector, IM (anterolateral thigh)

Epinephrine (1:1,000 solution), IM, 0.01 mg per kg per dose; maximal dose, 0.5 mg per dose (anterolateral thigh)

Epinephrine doses may need to be repeated every 5 to 15 minutes

Adjunctive treatment:

Bronchodilator (beta2 agonist): albuterol

Metered-dose inhaler (child: 4 to 8 puffs; adult: 8 puffs)

or

Nebulized solution (child: 1.5 mL; adult: 3 mL) every 20 minutes or continuously as needed

Histamine H1 antagonist: diphenhydramine (Benadryl)

1 to 2 mg per kg per dose; maximal dose, 50 mg IV or orally (liquid is more readily absorbed than tablets)

Alternative dosing may be with a less-sedating second-generation antihistamine

Supplemental oxygen therapy

Fluids IV in large volumes if patient presents with orthostasis, hypotension, or incomplete response to epinephrine IM

Place the patient in recumbent position if tolerated, with the lower extremities elevated

Hospital-based setting

First-line treatment:

Epinephrine IM as above, consider continuous epinephrine infusion for persistent hypotension (ideally with continuous noninvasive monitoring of blood pressure and heart rate); alternatives are endotracheal or intraosseous epinephrine

Adjunctive treatment:

Bronchodilator (beta2 agonist): albuterol

Metered-dose inhaler (child: 4 to 8 puffs; adult: 8 puffs)

or

Nebulized solution (child: 1.5 mL; adult: 3 mL) every 20 minutes or continuously as needed

Adjunctive treatment:

H1 antagonist: diphenhydramine

1 to 2 mg per kg per dose; maximal dose, 50 mg IV or orally (liquid is more readily absorbed than tablets)

Alternative dosing may be with a less-sedating second-generation antihistamine

Histamine H2 antagonist: ranitidine (Zantac)

1 to 2 mg per kg per dose; maximal dose, 75 to 150 mg IV or orally

Corticosteroids

Prednisone, 1 mg per kg; maximal dose, 60 to 80 mg orally

or

Methylprednisolone (Solu-Medrol), 1 mg per kg; maximal dose, 60 to 80 mg IV

Vasopressors (other than epinephrine) for refractory hypotension, titrate to effect

Glucagon (Glucagen) for refractory hypotension, titrate to effect (child: 20 to 30 mcg per kg; adult: 1 to 5 mg)

Dose may be repeated or followed by infusion of 5 to 15 mcg per minute

Atropine for bradycardia, titrate to effect

Supplemental oxygen therapy

Fluids IV in large volumes if patients present with orthostasis, hypotension, or incomplete response to epinephrine IM

Place the patient in recumbent position, if tolerated, with the lower extremities elevated

At discharge

First-line treatment:

Epinephrine autoinjector prescription (2 doses) and instructions

Education on avoidance of allergen

Follow-up with primary care physician

Consider referral to an allergist

Adjunctive treatment:

H1 antagonist: diphenhydramine every 6 hours for 2 to 3 days; alternative dosing with a nonsedating second-generation antihistamine

H2 antagonist: ranitidine twice daily for 2 to 3 days

Corticosteroid: prednisone daily for 2 to 3 days


note: These treatments often occur concomitantly and are not meant to be sequential, with the exception of epinephrine as first-line treatment.

IM = intramuscularly; IV = intravenously.

Adapted with permission from Boyce JA, Assa’ad A, Burks AW, et al.; NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-Sponsored Expert Panel. J Allergy Clin Immunol. 2010;126(6 suppl):S39.

Table 7.   Drugs for Anaphylaxis Management

View Table

Table 7.

Drugs for Anaphylaxis Management

Outpatient setting

First-line treatment:

Epinephrine, IM; autoinjector or 1:1,000 solution

22 to 56 lb (10 to 25 kg): 0.15-mg epinephrine autoinjector, IM (anterolateral thigh)

> 56 lb: 0.3-mg epinephrine autoinjector, IM (anterolateral thigh)

Epinephrine (1:1,000 solution), IM, 0.01 mg per kg per dose; maximal dose, 0.5 mg per dose (anterolateral thigh)

Epinephrine doses may need to be repeated every 5 to 15 minutes

Adjunctive treatment:

Bronchodilator (beta2 agonist): albuterol

Metered-dose inhaler (child: 4 to 8 puffs; adult: 8 puffs)

or

Nebulized solution (child: 1.5 mL; adult: 3 mL) every 20 minutes or continuously as needed

Histamine H1 antagonist: diphenhydramine (Benadryl)

1 to 2 mg per kg per dose; maximal dose, 50 mg IV or orally (liquid is more readily absorbed than tablets)

Alternative dosing may be with a less-sedating second-generation antihistamine

Supplemental oxygen therapy

Fluids IV in large volumes if patient presents with orthostasis, hypotension, or incomplete response to epinephrine IM

Place the patient in recumbent position if tolerated, with the lower extremities elevated

Hospital-based setting

First-line treatment:

Epinephrine IM as above, consider continuous epinephrine infusion for persistent hypotension (ideally with continuous noninvasive monitoring of blood pressure and heart rate); alternatives are endotracheal or intraosseous epinephrine

Adjunctive treatment:

Bronchodilator (beta2 agonist): albuterol

Metered-dose inhaler (child: 4 to 8 puffs; adult: 8 puffs)

or

Nebulized solution (child: 1.5 mL; adult: 3 mL) every 20 minutes or continuously as needed

Adjunctive treatment:

H1 antagonist: diphenhydramine

1 to 2 mg per kg per dose; maximal dose, 50 mg IV or orally (liquid is more readily absorbed than tablets)

Alternative dosing may be with a less-sedating second-generation antihistamine

Histamine H2 antagonist: ranitidine (Zantac)

1 to 2 mg per kg per dose; maximal dose, 75 to 150 mg IV or orally

Corticosteroids

Prednisone, 1 mg per kg; maximal dose, 60 to 80 mg orally

or

Methylprednisolone (Solu-Medrol), 1 mg per kg; maximal dose, 60 to 80 mg IV

Vasopressors (other than epinephrine) for refractory hypotension, titrate to effect

Glucagon (Glucagen) for refractory hypotension, titrate to effect (child: 20 to 30 mcg per kg; adult: 1 to 5 mg)

Dose may be repeated or followed by infusion of 5 to 15 mcg per minute

Atropine for bradycardia, titrate to effect

Supplemental oxygen therapy

Fluids IV in large volumes if patients present with orthostasis, hypotension, or incomplete response to epinephrine IM

Place the patient in recumbent position, if tolerated, with the lower extremities elevated

At discharge

First-line treatment:

Epinephrine autoinjector prescription (2 doses) and instructions

Education on avoidance of allergen

Follow-up with primary care physician

Consider referral to an allergist

Adjunctive treatment:

H1 antagonist: diphenhydramine every 6 hours for 2 to 3 days; alternative dosing with a nonsedating second-generation antihistamine

H2 antagonist: ranitidine twice daily for 2 to 3 days

Corticosteroid: prednisone daily for 2 to 3 days


note: These treatments often occur concomitantly and are not meant to be sequential, with the exception of epinephrine as first-line treatment.

IM = intramuscularly; IV = intravenously.

Adapted with permission from Boyce JA, Assa’ad A, Burks AW, et al.; NIAID-Sponsored Expert Panel. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-Sponsored Expert Panel. J Allergy Clin Immunol. 2010;126(6 suppl):S39.

Antihistamines are not appropriate as a primary treatment of anaphylaxis. Initial use of antihistamines is the most common reason for delaying or not using epinephrine, which places the patient at higher risk of progression toward a life-threatening reaction.2

Care of patients with food allergy–induced anaphylaxis after treatment of the acute episode should include a follow-up appointment with the patient’s physician and referral to an allergist.41 Care should also include education for the patient and family about avoidance of the offending food, early recognition of signs and symptoms of anaphylaxis, and use of an anaphylaxis emergency action plan. The plan should include appropriate use of epinephrine and the need for medical identification jewelry or an anaphylaxis wallet card.41,42  Table 5 includes a link to a sample anaphylaxis emergency plan. All patients with a history of food allergy–induced anaphylaxis should be given an epinephrine autoinjector prescription and training on how to use the device.2,41

Data Sources: The National Institute of Allergy and Infectious Diseases (NIAID) and the NIAID’s Expert Panel developed an extensive set of key questions, which was further refined in discussions with the RAND Evidence-Based Practice Center (EPC). The EPC was provided with the key questions relevant to the definition of food allergy, with comorbid conditions, natural history, diagnosis, and management of the disease. Literature searches were then performed using PubMed, the Cochrane Database of Systematic Reviews, the Cochrane Database of Abstracts of Reviews of Effects (DARE), the Cochrane Central Register of Controlled Trials (Central), and the World Allergy Organization Journal. The literature searches covered the period from January 1, 1988 through March 1, 2010. The principal search topics were diagnosis and testing techniques for food allergies in general, as well as specific immunoglobulin E (IgE)- and non–IgE-related reactions. In most cases, searches were limited to North American studies published between 1988 and 2010. In some cases, supplemental publications identified by the evidence panel and others involved in the review process were included in the literature review and analysis. The EPC’s report is available at http://www.rand.org/pubs/working_papers/WR757-1.html.

The Authors

BARBARA P. YAWN, MD, MSc, MSPH, FAAFP, is a director of research at Olmsted Medical Center, Rochester, Minn., and an adjunct professor in the Department of Family and Community Health at the University of Minnesota School of Medicine, Minneapolis.

MATTHEW J. FENTON, PhD, is the director of the Division of Extramural Research at the National Institute of Allergy and Infectious Diseases, Bethesda, Md.

Address correspondence to Barbara P. Yawn, MD, MSc, MSPH, FAAFP, Olmsted Medical Center, 210 Ninth Street SE, Rochester, MN 55904 (e-mail: byawn@olmmed.org). Reprints are not available from the authors.

Author disclosure: Drs. Yawn and Fenton served on the NIAID-sponsored expert panel that authored the Guidelines for the Diagnosis and Management of Food Allergy in the United States.

The authors acknowledge the NIAID-sponsored expert panel (S. Hasan Arshad, MBBS, MRCP, DM, FRCP; Amal Assa’ad, MD; Sami L. Bahna, MD, DrPH; Lisa A. Beck, MD; Joshua A. Boyce, MD; A. Wesley Burks, MD; Carol Byrd-Bredbenner, PhD, RD, FADA; Carlos A. Camargo, Jr., MD, DrPH; Lawrence Eichenfield, MD; Glenn T. Furuta, MD; Jon M. Hanifin, MD; Carol Jones, RN, AE-C; Stacie M. Jones, MD; Monica Kraft, MD; Bruce D. Levy, MD; Chris A. Liacouras, MD; Phil Lieberman, MD; Stefano Luccioli, MD; Kathleen M. McCall, BSN, RN; Hugh A. Sampson, MD; Lynda C. Schneider, MD; Ronald A. Simon, MD; F. Estelle R. Simons, MD; Stephen J. Teach, MD, MPH; and Robert A. Wood, MD) for their work in the creation of the guidelines for the diagnosis and management of food allergy. The authors also thank Susan F. Cooper, MSc; Marshall Plaut, MD; and Julie M. Schwaninger, MSc, of the NIAID for their contributions.

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