Vitamin D Does Not Affect Isolated Systolic Hypertension


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Am Fam Physician. 2013 Dec 1;88(11):739-744.

Clinical Question

Does treatment with vitamin D lower blood pressure in older patients with isolated systolic hypertension and low vitamin D levels?

Bottom Line

Vitamin D supplementation in patients with isolated systolic hypertension and low levels of vitamin D does not decrease systolic blood pressure after one year of treatment. (Level of Evidence = 1b)


Because low vitamin D levels are associated with hypertension, Scottish researchers investigated the role of vitamin D supplementation in 159 patients, at least 70 years of age, with isolated systolic hypertension greater than 140 mm Hg and vitamin D levels (25-hydroxyvitamin D) of less than 30 ng per mL (75 nmol per L). Using concealed allocation, patients were randomized to receive oral placebo or cholecalciferol at a dosage of 100,000 IU every three months for one year. As expected, vitamin D levels increased an average of 8 ng per mL (20 nmol per L) in the treated patients. Systolic blood pressure, though, did not significantly change or differ between the groups (0.8 mm Hg). Similarly, other measures—24-hour blood pressure, arterial stiffness, endothelial function—did not change.

Study design: Randomized controlled trial (double-blinded)

Funding source: Government

Allocation: Concealed

Setting: Outpatient (any)

Reference: Witham MD, Price RJ, Struthers AD, et al. Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension: the VitDISH randomized controlled trial [published ahead of print August 12, 2013]. JAMA Intern Med. http://archinte.jamanetwork.com/article.aspx?articleid=1726994. Accessed October 4, 2013.

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.


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