Intensive Lifestyle Intervention Fails to Improve Patient-Oriented Outcomes in Persons with Obesity and Diabetes

FREE PREVIEW Log in or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.

FREE PREVIEW Subscribe or buy this issue. AAFP members and paid subscribers get free access to all articles.

Am Fam Physician. 2013 Dec 15;88(12):online.

Clinical Question

Does an intensive lifestyle intervention focused on weight loss and exercise improve outcomes in patients with diabetes mellitus?

Bottom Line

This large, well-designed trial failed to find a statistically significant improvement in patient-oriented outcomes in patients with diabetes, despite a fairly intensive lifestyle intervention and long-term follow-up. (Level of Evidence = 1b)


There is relatively little high-quality clinical trial evidence to support recommendations for weight loss and exercise in patients with type 2 diabetes. In this study, 5,145 adults, 45 to 75 years of age, with type 2 diabetes and a body mass index of at least 25 kg per m2 were randomized to receive an intensive lifestyle intervention (weekly visits providing group and individual counseling regarding calorie-reducing diet and exercise, with a goal of 7% weight loss and at least 175 minutes of exercise

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

Want to use this article elsewhere? Get Permissions

Article Tools

  • Download PDF
  • Print page
  • Share this page
  • AFP CME Quiz

More in Pubmed

Navigate this Article