POEMs

Fewer Deaths/Strokes/Revascularizations with Metformin Than Glipizide



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Am Fam Physician. 2014 Jan 15;89(2):131.

Clinical Question

Does metformin (Glucophage) affect cardiovascular events in patients with type 2 diabetes mellitus?

Bottom Line

Over five years, treatment with metformin for three years, with other hypoglycemics as needed, reduced the likelihood of death, nonfatal stroke, or the need for vascularization compared with treatment beginning with glipizide (Glucotrol). Cardiovascular events were not individually reduced with metformin compared with glipizide. (Level of Evidence = 1b–)

Synopsis

These authors enrolled patients with type 2 diabetes and coronary artery disease, and followed them for a median of five years. The average age of all 304 patients was 63.3 years; 77% were men. After

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

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