POEMs

No Effect of Vitamin D on Depressive Symptoms



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Am Fam Physician. 2014 Jan 15;89(2):131-136.

Clinical Question

In patients with low vitamin D levels, does vitamin D supplementation improve symptoms of depression?

Bottom Line

Taken in aggregate, symptoms of depression do not improve in patients with low vitamin D levels when given vitamin D supplementation any more than when given placebo. There may be a benefit in patients with low vitamin D levels and mild to moderate depression. (Level of Evidence = 1b–)

Synopsis

This study was conducted in Norway, where researchers started by identifying patients with depressive symptoms and low vitamin D levels (< 22 ng per mL [< 55 nmol per L]). The

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.


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