Pioglitazone Exposure Increases Bladder Cancer Risk
FREE PREVIEW Log in or buy this issue to read the full article. AAFP members and paid subscribers get free access to all articles. Subscribe now.
FREE PREVIEW Subscribe or buy this issue. AAFP members and paid subscribers get free access to all articles.
Am Fam Physician. 2014 Jan 15;89(2):136.
Do adults with type 2 diabetes mellitus who are treated with pioglitazone (Actos) have an increased risk of bladder cancer?
This review of all available data found a significantly increased risk of bladder cancer among adults with type 2 diabetes treated with pioglitazone. Pioglitazone also significantly increases the risk of heart failure, and there is minimal, if any, patient-oriented evidence of benefit from treatment (Richter B, Bandeira-Echtler E, Bergerhoff K, Clar C, Ebrahim SH. Cochrane Database Syst Rev. 2006; :CD006060). The French and German governments have suspended or strongly curtailed the use of pioglitazone. It lowers A1C levels, but I would not want my loved ones taking this stuff. (Level of Evidence = 2b)
Because of concern that pioglitazone is associated with an increased
POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.
For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.
To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.
Want to use this article elsewhere? Get Permissions