POEMs

Platelet-Rich Plasma May Minimally, If at All, Benefit Patients with Knee Osteoarthritis


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Am Fam Physician. 2014 Apr 1;89(7):578.

Clinical Question

Is the injection of platelet-rich plasma beneficial in the management of symptomatic knee osteoarthritis in adults?

Bottom Line

Compared with normal saline or hyaluronic acid, multiple intra-articular injections of platelet-rich plasma significantly improved knee function but did not reduce perceived pain or improve patient satisfaction in adults with symptomatic knee osteoarthritis. (Level of Evidence = 1a–)

Synopsis

These investigators thoroughly searched Medline, Embase, the Cochrane Register, and bibliographies of retrieved citations for studies that evaluated the effectiveness of intra-articular platelet-rich plasma for the treatment of knee osteoarthritis in adults. They included only high-quality

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley- Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

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