Platelet-Rich Plasma May Minimally, If at All, Benefit Patients with Knee Osteoarthritis
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Am Fam Physician. 2014 Apr 1;89(7):578.
Is the injection of platelet-rich plasma beneficial in the management of symptomatic knee osteoarthritis in adults?
Compared with normal saline or hyaluronic acid, multiple intra-articular injections of platelet-rich plasma significantly improved knee function but did not reduce perceived pain or improve patient satisfaction in adults with symptomatic knee osteoarthritis. (Level of Evidence = 1a–)
These investigators thoroughly searched Medline, Embase, the Cochrane Register, and bibliographies of retrieved citations for studies that evaluated the effectiveness of intra-articular platelet-rich plasma for the treatment of knee osteoarthritis in adults. They included only high-quality
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