POEMs

Testosterone Therapy in Men Associated with an Increase in the Risk of Nonfatal MI


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Am Fam Physician. 2014 Jun 1;89(11):907.

Clinical Question

Does testosterone therapy increase the risk of myocardial infarction (MI) in men?

Bottom Line

Filling a prescription for testosterone therapy is associated with an increased likelihood of experiencing an MI, especially in older men and those with a history of cardiovascular disease. (Level of Evidence = 2b)

Synopsis

Men are increasingly taking testosterone supplements, even if they are not hypogonadal. In addition to an absence of evidence regarding effectiveness, previous studies have raised concerns about the safety of this practice. These researchers identified a large cohort of men who had received a first prescription for testosterone therapy

POEMs (patient-oriented evidence that matters) are provided by Essential Evidence Plus, a point-of-care clinical decision support system published by Wiley- Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.



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