Varenicline Plus Bupropion SR No Better Than Varenicline Alone for Tobacco Cessation

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Am Fam Physician. 2014 Jun 1;89(11):912-913.

Clinical Question

Is the combination of varenicline (Chantix) and sustained-release bupropion (Zyban) superior to varenicline alone for increasing smoking cessation rates in adult smokers?

Bottom Line

Combination therapy with varenicline and sustained-release bupropion was associated with a significantly higher prolonged abstinence rate compared with varenicline monotherapy at 12 weeks and 26 weeks in adult smokers attempting to quit. By 52 weeks, however, the difference was no longer statistically significant. Adverse events, particularly anxiety and depression, were significantly more common in the combination therapy group. Combination therapy was significantly more successful for achieving prolonged abstinence at 12, 26, and 52 weeks among heavy smokers (at least 20 cigarettes daily; number needed to treat = 8.6; 95% confidence interval, 4.6 to 71.6). (Level of Evidence

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