Letters to the Editor
Consider Thin Basement Membrane Nephropathy as a Possible Cause of Asymptomatic Microscopic Hematuria
FREE PREVIEW. AAFP members and paid subscribers: Log in to get free access. All others: Purchase online access.
FREE PREVIEW. Purchase online access to read the full version of this article.
Am Fam Physician. 2014 Oct 1;90(7):434.
Original Article: Assessment of Asymptomatic Microscopic Hematuria in Adults
Issue Date: December 1, 2013
See additional reader comments at: http://www.aafp.org/afp/2013/1201/p747.html
to the editor: Thanks to the authors for this clear and timely article. I would like to add a few words on benign hereditary nephritis, now known as thin basement membrane nephropathy.1 In the late 1970s, I followed five generations totaling 207 patients with this condition in Lancaster and Chester Counties, Pa.; Cecil County, Md.; and Ashe County, N.C.2 These patients had intermittent microscopic hematuria and a high but intermittent incidence of red blood cell casts. No evidence of progression of renal disease was found. Descendants of this group resided in at least 14 states.
For patients with microscopic hematuria who have not received a definitive diagnosis after a thorough workup before kidney biopsy, physicians should evaluate for a family history of recurring intermittent microscopic hematuria with intermittent red blood cell casts. Thin basement membranes are found in 5% to 9% of transplanted kidneys, but thin basement membrane nephropathy is found in less than 1% of the population. Thin basement membrane nephropathy and immunoglobulin A nephropathy are now considered common causes of asymptomatic hematuria after malignancy has been excluded.
Author disclosure: No relevant financial affiliations.
1. Kashtan CE. Thin basement membrane nephropathy (benign familial hematuria). UpToDate http://www.uptodate.com/contents/thin-basement-membrane-nephropathy-benign-familial-hematuria (subscription required). Accessed June 2, 2014.
2. Peterson AS, Schubert JJ. Benign hereditary nephritis. J Fam Pract. 1977;4(3):437–441.
Send letters to firstname.lastname@example.org, or 11400 Tomahawk Creek Pkwy., Leawood, KS 66211-2680. Include your complete address, e-mail address, and telephone number. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors.
Letters submitted for publication in AFP must not be submitted to any other publication. Possible conflicts of interest must be disclosed at time of submission. Submission of a letter will be construed as granting the AAFP permission to publish the letter in any of its publications in any form. The editors may edit letters to meet style and space requirements.
This series is coordinated by Kenny Lin, MD, MPH, Associate Deputy Editor for AFP Online.
Copyright © 2014 by the American Academy of Family Physicians.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact email@example.com for copyright questions and/or permission requests.
Want to use this article elsewhere? Get Permissions