Am Fam Physician. 2015 Sep 1;92(5):390.
Can insulin sensitizers be used to treat menstrual irregularities associated with polycystic ovary syndrome (PCOS)?
Metformin, pioglitazone (Actos), and rosiglitazone (Avandia) can be used to improve menstrual cycling in women with PCOS. (Strength of Recommendation [SOR]: A, based on a meta-analysis.) However, metformin is much less effective than oral contraceptives (OCs). (SOR: A, based on a meta-analysis of randomized controlled trials [RCTs].)
A Cochrane review of 44 RCTs (N = 3,992) assessed the effectiveness of insulin-sens
1. Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev. 2012;(5):CD003053.
2. Costello M, Shrestha B, Eden J, Sjoblom P, Johnson N. Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev. 2007;(1):CD005552.
3. Tfayli H, Ulnach JW, Lee S, Sutton-Tyrrell K, Arslanian S. Drospirenone/ethinyl estradiol versus rosiglitazone treatment in overweight adolescents with polycystic ovary syndrome: comparison of metabolic, hormonal, and cardiovascular risk factors. J Clin Endocrinol Metab. 2011;96(5):1311–1319.
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