Cochrane for Clinicians
Putting Evidence into Practice
Calcium Supplementation for Preventing Hypertensive Disorders in Pregnancy
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Am Fam Physician. 2015 Oct 1;92(7):570-571.
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Does calcium supplementation prevent hypertensive disorders in pregnancy?
High-dose calcium supplementation (i.e., at least 1,000 mg per day) during pregnancy reduces the risk of developing hypertension and preeclampsia. The most significant risk reduction occurs in women at risk of hypertensive disorders and those with low-calcium diets. (Strength of Recommendation: A, based on consistent, good-quality patient-oriented evidence.)
Hypertensive disorders occur in up to 10% of pregnancies and are a major source of fetal and maternal morbidity and mortality.1 Although early recognition and treatment have improved some outcomes, the pathogenesis of preeclampsia spectrum disorders is still not well understood. The incidence of all hypertensive disorders of pregnancy is increasing
The practice recommendations in this activity are available at http://summaries.cochrane.org/CD001059.
Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2014;(6):CD001059.
1. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122–1131.
2. Bailey RL, Dodd KW, Goldman JA, et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010;140(4):817–822.
3. World Health Organization. Guideline: calcium supplementation in pregnant women. Geneva, Switzerland: WHO; 2013. http://apps.who.int/iris/bitstream/10665/85120/1/9789241505376_eng.pdf?ua=1. Accessed June 5, 2015.
These are summaries of reviews from the Cochrane Library.
This series is coordinated by Corey D. Fogleman, MD, Assistant Medical Editor.
A collection of Cochrane for Clinicians published in AFP is available at http://www.aafp.org/afp/cochrane.
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