Am Fam Physician. 2015 Oct 1;92(7):640-642.
Are there subgroups of patients with acute lower respiratory tract infection (LRTI) who do not have clinically suspected pneumonia but who may benefit from antibiotics?
Patients with acute LRTI and green sputum or cardiopulmonary comorbidities experience a slightly greater benefit with amoxicillin treatment. That outcome must be balanced against the harms of antibiotics on the individual and population level. (Level of Evidence = 1b –)
This is a secondary analysis of data from a large European randomized trial of the treatment of acute LRTI. These researchers recruited 2,061 adults with acute LRTI but no suspected pneumonia. The patients were randomized to receive 1 g of amoxicillin three times daily for seven days or matching placebo. A
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This series is coordinated by Sumi Sexton, MD, Associate Medical Editor.
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