Am Fam Physician. 2015 Nov 1;92(9):814.
Does continuing warfarin (Coumadin) for 18 months after an unprovoked pulmonary embolism (PE) reduce the risk of recurrent venous thrombotic events?
Continuing warfarin therapy for 18 months after an unprovoked PE reduces the risk of recurrent symptomatic venous thromboembolism (VTE). However, benefit beyond 18 months is not maintained after the warfarin is discontinued. (Level of Evidence = 1b)
Patients with unprovoked VTE have a higher risk of recurrence than those with a provoked event. This is the first study to evaluate extended anticoagulation beyond six months for patients with unprovoked PE. The authors enrolled adults (N = 371), 18 years or older, who received six months of therapy with a vitamin K antagonist f
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