In Patients with Type 2 Diabetes and CV Disease, Empagliflozin Reduces CV and All-Cause Mortality


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Am Fam Physician. 2016 Mar 1;93(5):410.

Clinical Question

In patients with type 2 diabetes mellitus and cardiovascular (CV) disease, does the addition of empagliflozin (Jardiance) improve outcomes?

Bottom Line

In patients with established CV disease and type 2 diabetes, the addition of empagliflozin to standard therapy reduces all-cause mortality and CV mortality. This is notable because empagliflozin is the only drug other than metformin to demonstrate a mortality benefit, albeit for a fairly narrow group of patients. A dose of 10 mg appears to provide a similar benefit to the 25-mg dose, but with half the risk of genital infections. It is not appropriate to extend these conclusions to all patients with type 2 diabetes, because they are at lower risk of bad outcomes and are unlikely to benefit to the same degree. (Level of Evidence = 1b)


Empagliflozin decreases reabsorption of glucose in the kidneys, leading to

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

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This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.


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Oct 15, 2016

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