Am Fam Physician. 2016 Mar 1;93(5):410.
In patients with type 2 diabetes mellitus and cardiovascular (CV) disease, does the addition of empagliflozin (Jardiance) improve outcomes?
In patients with established CV disease and type 2 diabetes, the addition of empagliflozin to standard therapy reduces all-cause mortality and CV mortality. This is notable because empagliflozin is the only drug other than metformin to demonstrate a mortality benefit, albeit for a fairly narrow group of patients. A dose of 10 mg appears to provide a similar benefit to the 25-mg dose, but with half the risk of genital infections. It is not appropriate to extend these conclusions to all patients with type 2 diabetes, because they are at lower risk of bad outcomes and are unlikely to benefit to the same degree. (Level of Evidence = 1b)
Empagliflozin decreases reabsorption of glucose in the kidneys, leading to
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