No Difference Between Oxycodone/Acetaminophen and Hydrocodone/Acetaminophen for Acute Extremity Pain
Am Fam Physician. 2016 Mar 1;93(5):411.
How effective is oxycodone/acetaminophen compared with hydrocodone/acetaminophen in the management of acute extremity pain in adults, including sprains/strains and fractures?
This study found no significant difference in the management of acute musculoskeletal extremity pain, including fractures, with oxycodone/acetaminophen vs. hydrocodone/acetaminophen. Adverse events, including nausea and dizziness, occurred significantly more often with oxycodone/acetaminophen (number needed to treat to harm = 10). (Level of Evidence = 1b)
It is commonly believed that oxycodone/acetaminophen provides better pain relief than hydrocodone/acetaminophen for adults with acute pain. These investigators identified adults (N = 240), 21 to 64 years of age, who presented to an urban emergency department
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