Am Fam Physician. 2016 Apr 15;93(8):704.
Do hyaluronic acid injections in patients with knee degenerative joint disease (DJD) improve pain and function?
The highest quality studies, which are now fairly plentiful, show that hyaluronic acid injections are only minimally better than sham injections in improving pain and function in patients with knee DJD. (Level of Evidence = 1a−)
These authors searched multiple databases and a clinical trial registry to identify randomized trials comparing hyaluronic acid injections with control treatments in patients with knee DJD. Studies had to include
POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.
For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.
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This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.
A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.
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