Am Fam Physician. 2016 May 1;93(9):790.
Should nitrates be prescribed for patients who have heart failure with preserved ejection fraction?
Patients who have heart failure with preserved ejection fraction had decreased levels of activity and more adverse events when they were receiving isosorbide mononitrate than when they were taking a placebo. Moreover, activity levels decreased with increases in the dose of the drug, suggesting a strong correlation. However, almost 90% of the patients in this study were white, which may limit its generalizability. (Level of Evidence = 1b)
Previous studies note that up to 50% of patients who have heart failure with preserved ejection fraction receive nitrates, but the effectiveness of this therapy has not been extensively studied in this population. In the current trial, investigators enrolled patients with a diagnosis
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