POEMs

Chondroitin/Glucosamine Equal to Celecoxib for Knee Osteoarthritis

 


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Am Fam Physician. 2016 Jun 15;93(12):1032.

Clinical Question

Is combined chondroitin/glucosamine as effective as celecoxib (Celebrex) in reducing pain and improving function in patients with painful knee osteoarthritis?

Bottom Line

For patients with painful knee osteoarthritis, a high-dose combination of glucosamine hydrochloride (1,500 mg) and chondroitin (1,200 mg) was as effective in lessening pain and stiffness and improving function as celecoxib (200 mg). Other studies have not found benefit. It is time for someone to analyze all the studies of chondroitin/glucosamine to determine who is most likely to benefit. (Level of Evidence = 1b)

Synopsis

The 606 patients in this study were enrolled by one of 42 rheumatologists practicing

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP,search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.



 

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