Meta-Analysis: Intensive BP Control Decreases Major CV Events and Stroke, but Not MI, Heart Failure, or Mortality


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Am Fam Physician. 2016 Jun 15;93(12):1036-1037.

Clinical Question

Does intensive lowering of blood pressure (BP) improve the lives of patients with hypertension?

Bottom Line

Patients with hypertension who are treated intensively are less likely to have major cardiovascular (CV) events, stroke, or progression of albuminuria or retinopathy than those treated less intensively, but intensive lowering had no meaningful effect on myocardial infarctions (MIs), heart failure, or mortality. (Level of Evidence = 1a)


This team of researchers reviewed several databases and registries to identify randomized trials that lasted at least six months and that compared more intensive vs. less intensive BP lowering in patients with hypertension. Two authors independently determined which

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP,search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.


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Oct 15, 2016

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