Am Fam Physician. 2016 Sep 1;94(5):386.
Are newer-generation sulfonylureas associated with bad outcomes in patients with type 2 diabetes mellitus?
In multiple randomized trials, the long-term use of second- or third-generation sulfonylureas in patients with type 2 diabetes is not associated with more deaths, myocardial infarctions (MIs), or strokes. The included trials tended not to report other safety data. (Level of Evidence = 1a)
These authors reviewed two databases and the Cochrane Library to identify randomized trials of second- or third-generation sulfonylureas in patients with type 2 diabetes. Additionally, they searched for unpublished studies by looking at clinical trial registries and the abstracts of international diabetes meetings. The trials had to be at least one year in duration and evaluate all-cause or cardiovascular mortality.
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