Photo Quiz

Unusual Urine Color During Catheterization

 

Am Fam Physician. 2016 Oct 1;94(7):572-574.

A 50-year-old woman presented for a routine catheter change. The patient was wheelchair-bound because of a history of transverse myelitis. She had urinary incontinence and was dependent on chronic urinary catheterization. The patient had no symptoms beyond discolored urine. There was no dysuria or blood around the catheter. She had no history of trauma to the catheter.

On examination, she was afebrile and well appearing, but the urine in her catheter bag looked purple (Figure 1). She did not know how long her urine had been discolored. Urinalysis showed leukocytes and microscopic hematuria. The urine was sent for culture.

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Figure 1.


Figure 1.

Question

Based on the patient's history and physical examination findings, which one of the following is the most likely diagnosis?

A. Excessive blackberry or beet consumption.

B. Familial benign hypercalcemia.

C. Isoniazid use.

D. Nitrofurantoin use.

E. Purple urine bag syndrome.

Discussion

The answer is E: purple urine bag syndrome. The urine's purple shade (which leads to staining of the catheter's bag and collecting tube) is caused by the accumulation of tryptophan metabolites. Dietary tryptophan is metabolized by gastrointestinal bacteria, which results in indole production. Indole is converted to indole sulfate in the liver. Indole sulfate in turn is acted on by bacterial enzymes, resulting in the production of indirubin (which is red) and indigo (which is blue). These metabolites concentrate in the urine, and the combination of red and blue pigments produces the purple discoloration.1

Purple urine bag syndrome is more common in older women with chronic urinary catheters,2 and it may be associated with constipation, dehydration, and alkaline urine. The condition has also been associated with intussusception.3 Most persons with purple urine bag syndrome are not seriously ill, although the condition is associated with several bacterial infections. Causative organisms include Providencia, Citrobacter, Enterobacter, Klebsiella, Morganella, Staphylococcus, and Streptococcus.4 It has been suggested that the urine is not purple but brownish-red, and that the urine bag is discolored purple. This may be because of a reaction of the indirubin and indigo pigments with the lining of the bag and catheter.5

Many medications, foods, dyes, and medical conditions can cause urine discoloration. A 2012 review details the differential diagnosis of abnormally colored urine and includes more than 75 items. The differential diagnosis for purple urine or a purple urine bag seems to be limited to purple urine bag syndrome, however.6

Eating excessive amounts of blackberries, beets, or carrots is associated with red, but not purple, urine. The medication isoniazid often results in orange urine. The medication nitrofurantoin can produce brown or black urine. White, blue, and green urine are also possible. Familial benign hypercalcemia is sometimes termed blue diaper syndrome because this rare condition is associated with blue urine.6

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Selected Medical Conditions Resulting in Abnormal Urine Color

Urine colorMedical conditions

Brown

Hemolysis

Metastatic melanoma

Porphyria

Black

Alcaptonuria

Metastatic melanoma

Porphyria

White

Chyluria

Filariasis

Hypercalciuria

Hyperoxaluria

Lipiduria

Lymphatic fistula

Phosphaturia

Proteinuria

Pyuria due to urinary tract infection

Schistosomiasis

Urinary tuberculosis

Blue or green

Biliverdin

Blue diaper syndrome (familial benign hypercalcemia)

Hartnup disease

Porphyria

Pseudomonas urinary tract infection

Purple

Purple urine bag syndrome


note: Red/orange urine is usually related to hematuria. Causes related to medications are not included in this table.

Information from reference 6.

Selected Medical Conditions Resulting in Abnormal Urine Color

Urine colorMedical conditions

Brown

Hemolysis

Metastatic melanoma

Porphyria

Black

Alcaptonuria

Metastatic melanoma

Porphyria

White

Chyluria

Filariasis

Hypercalciuria

Hyperoxaluria

Lipiduria

Lymphatic fistula

Phosphaturia

Proteinuria

Pyuria due to urinary tract infection

Schistosomiasis

Urinary tuberculosis

Blue or green

Biliverdin

Blue diaper syndrome (familial benign hypercalcemia)

Hartnup disease

Porphyria

Pseudomonas urinary tract infection

Purple

Purple urine bag syndrome


note: Red/orange urine is usually related to hematuria. Causes related to medications are not included in this table.

Information from reference 6.

Address correspondence to Michael D. Burg, MD, at WedgeRecs@aol.com. Reprints are not available from the authors.

Author disclosure: No relevant financial affiliations.

REFERENCES

show all references

1. Hadano Y, Shimizu T, Takada S, Inoue T, Sorano S. An update of purple urine bag syndrome. Int J Gen Med. 2012;5:707–710....

2. Ribeiro JP, Marcelino P, Marum S, Fernandes AP, Grilo A. Case report: purple urine bag syndrome. Crit Care. 2004;8(3):R137.

3. Pillai RN, Clavijo J, Narayanan M, Zaman K. An association of purple urine bag syndrome with intussusception. Urology. 2007;70(4):812.e1–2.

4. Pillai BP, Chong VH, Yong AM. Purple urine bag syndrome. Singapore Med J. 2009;50(5):e193–e194.

5. Chong VH. Purple urine bag syndrome: it is the urine bag and not the urine that is discolored purple. South Med J. 2012;105(8):446.

6. Aycock RD, Kass DA. Abnormal urine color. South Med J. 2012;105(1):43–47.

This series is coordinated by John E. Delzell Jr., MD, MSPH, Assistant Medical Editor.

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