Third-Generation Oral Contraceptives Associated with Greater Risk of PE, Stroke, and MI
Am Fam Physician. 2016 Oct 15;94(8):663.
Which oral contraceptive combinations have the highest risk of cardiovascular effects?
Although there is risk with any current oral contraceptive combination, those that contain lower doses of estrogen, and levonorgestrel instead of desogestrel or gestodene, are associated with the least risk of ischemic stroke, myocardial infarction (MI), or pulmonary embolism (PE). These safer products are older so are often less expensive. This is not the first study to show this difference, but its enrollment of 5 million women may make it the largest. (Level of Evidence = 2b)
This study, conducted in France, used the national health insurance database to identify all women who filled at least one
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